A Study to Assess the Efficacy and Safety of FORE8394 in Participants With Cancer Harboring BRAF Alterations
Public ClinicalTrials.gov record NCT05503797. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
A Phase 2 Master Protocol to Assess the Efficacy and Safety of FORE8394, an Inhibitor of BRAF Class 1 and Class 2 Alterations, in Participants With Cancer Harboring BRAF Alterations
Study identification
- NCT ID
- NCT05503797
- Recruitment status
- Recruiting
- Study type
- Interventional
- Phase
- Phase 2
- Lead sponsor
- Fore Biotherapeutics
- Industry
- Enrollment
- 254 participants
Conditions and interventions
Conditions
Interventions
- Plixorafenib Drug
Drug
Eligibility (public fields only)
- Age range
- 10 Years and older
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Feb 20, 2023
- Primary completion
- Jun 26, 2026
- Completion
- Dec 27, 2026
- Last update posted
- Apr 2, 2026
2023 – 2026
United States locations
- U.S. sites
- 28
- U.S. states
- 18
- U.S. cities
- 24
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| Precision NextGen Oncology & Research Center | Beverly Hills | California | 90210 | Recruiting |
| UCSF Helen Diller Family Comprehensive Cancer Center | San Francisco | California | 94143 | Recruiting |
| University of California Los Angeles Rheumatology | Westwood, Los Angeles | California | 90095-6984 | Recruiting |
| Norwalk Hospital | Norwalk | Connecticut | 06856 | Recruiting |
| University of Miami Hospital and Clinics | Miami | Florida | 33136 | Recruiting |
| The John Hopkins Hospital | Baltimore | Maryland | 21287 | Recruiting |
| Maryland Oncology Hematology- Columbia | Rockville | Maryland | 20850 | Recruiting |
| Tufts Medical Center | Boston | Massachusetts | 02111 | Recruiting |
| Massachusetts General Hospital | Boston | Massachusetts | 02214 | Recruiting |
| Dana-Farber Cancer Institute | Boston | Massachusetts | 02215 | Not yet recruiting |
| St. Luke's Hospital | Duluth | Minnesota | 55805 | Recruiting |
| Mosaic Life Care at Saint Joseph - Medical Center | Saint Joseph | Missouri | 64506 | Recruiting |
| Nebraska Cancer Specialists - Midwest Cancer Center - Legacy | Omaha | Nebraska | 68130 | Recruiting |
| Overlook Medical Center | Summit | New Jersey | 07901 | Recruiting |
| Columbia University Irving Medical Center | New York | New York | 10032 | Recruiting |
| Memorial Sloan Kettering Cancer Center | New York | New York | 10065 | Recruiting |
| Atrium Health Wake Forest Baptist - Comprehensive Cancer Center | Winston-Salem | North Carolina | 27157 | Recruiting |
| Nationwide Children's Hospital | Columbus | Ohio | 43205 | Recruiting |
| Taylor Cancer Research Center | Maumee | Ohio | 43537 | Recruiting |
| Toledo Clinic Cancer Center | Toledo | Ohio | 43623 | Completed |
| Thomas Jefferson University | Philadelphia | Pennsylvania | 19107 | Recruiting |
| Lifespan Cancer Institute - Rhode Island Hospital | Providence | Rhode Island | 02903 | Recruiting |
| SCRI - TriStar Medical Group Children's Specialists | Nashville | Tennessee | 37203 | Recruiting |
| SCRI Oncology Partners | Nashville | Tennessee | 37203 | Recruiting |
| Baylor Scott & White Research Institute | Dallas | Texas | 75246 | Recruiting |
| Baylor Scott & White Medical Center | Temple | Texas | 43205 | Recruiting |
| University of Washington School of Medicine | Seattle | Washington | 98109 | Recruiting |
| West Virginia University Health Sciences Campus | Morgantown | West Virginia | 26506 | Recruiting |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
Non-U.S. locations
This page focuses on the U.S. directory. The official record also lists 39 non-U.S. sites.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT05503797, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Apr 2, 2026 · Synced May 6, 2026
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Open the official record
The complete protocol, eligibility criteria, and contact information for NCT05503797 live on ClinicalTrials.gov.