A Study to Give Treatment Inside the Eye to Treat Retinoblastoma

ClinicalTrials.gov ID: NCT05504291

Public ClinicalTrials.gov record NCT05504291. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.

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ClinicalTrials.gov public records Last synced May 18, 2026, 1:28 PM EDT

Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.

Official title

Intravitreal Melphalan for Intraocular Retinoblastoma

Study identification

NCT ID: NCT05504291
Recruitment status: Recruiting
Study type: Interventional
Phase: Phase 2
Lead sponsor: Children's Oncology Group; Network
Enrollment: 26 participants

Conditions and interventions

Conditions

Interventions

Biospecimen Collection Procedure
Carboplatin Drug
Etoposide Drug
Examination Under Anesthesia Procedure
Magnetic Resonance Imaging Procedure
Melphalan Drug
Ultrasound Biomicroscopy Procedure
Vincristine Drug

Procedure · Drug

Eligibility (public fields only)

Age range: Up to 18 Years
Sex: All
Healthy volunteers: Healthy volunteers not accepted

This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.

Study timeline

Start date: Nov 3, 2022
Primary completion: Mar 30, 2028
Completion: Mar 30, 2028
Last update posted: Feb 16, 2026

2022 – 2028

United States locations

U.S. sites: 17
U.S. states: 12
U.S. cities: 16

Facility	City	State	ZIP	Site status
Children's Hospital of Alabama	Birmingham	Alabama	35233	Recruiting
Children's Hospital Los Angeles	Los Angeles	California	90027	Recruiting
Lucile Packard Children's Hospital Stanford University	Palo Alto	California	94304	Recruiting
Children's Hospital Colorado	Aurora	Colorado	80045	Recruiting
Children's Healthcare of Atlanta - Arthur M Blank Hospital	Atlanta	Georgia	30329	Recruiting
C S Mott Children's Hospital	Ann Arbor	Michigan	48109	Recruiting
Washington University School of Medicine	St Louis	Missouri	63110	Recruiting
Duke University Medical Center	Durham	North Carolina	27710	Recruiting
Children's Hospital Medical Center of Akron	Akron	Ohio	44308	Recruiting
Cleveland Clinic Foundation	Cleveland	Ohio	44195	Recruiting
Saint Jude Children's Research Hospital	Memphis	Tennessee	38105	Recruiting
Dell Children's Medical Center of Central Texas	Austin	Texas	78723	Recruiting
UT Southwestern/Simmons Cancer Center-Dallas	Dallas	Texas	75390	Recruiting
Baylor College of Medicine/Dan L Duncan Comprehensive Cancer Center	Houston	Texas	77030	Recruiting
M D Anderson Cancer Center	Houston	Texas	77030	Recruiting
Primary Children's Hospital	Salt Lake City	Utah	84113	Active, not recruiting
Children's Hospital of Wisconsin	Milwaukee	Wisconsin	53226	Recruiting

Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.

Non-U.S. locations

This page focuses on the U.S. directory. The official record also lists 3 non-U.S. sites.

About this trial record page

What this page shows: Public field values for ClinicalTrials.gov record NCT05504291, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
What this page does not do: No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
Where the data comes from: Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
Last refresh: Last update posted Feb 16, 2026 · Synced May 18, 2026

Open the official record

The complete protocol, eligibility criteria, and contact information for NCT05504291 live on ClinicalTrials.gov.

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