A Phase 2 Study of Avutometinib (VS-6766) Plus Defactinib
Public ClinicalTrials.gov record NCT05512208. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
A Phase 2 Study of VS-6766 (Dual RAF/MEK Inhibitor) Plus Defactinib (FAK Inhibitor) in Recurrent Gynecological Cancers (DURAFAK)
Study identification
- NCT ID
- NCT05512208
- Recruitment status
- Recruiting
- Study type
- Interventional
- Phase
- Phase 2
- Lead sponsor
- University of Oklahoma
- Other
- Enrollment
- 55 participants
Conditions and interventions
Conditions
Interventions
- Avutometinib (VS-6766) + defactinib Drug
Drug
Eligibility (public fields only)
- Age range
- 18 Years to 99 Years
- Sex
- Female
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Feb 5, 2023
- Primary completion
- Nov 30, 2027
- Completion
- Nov 30, 2029
- Last update posted
- Oct 21, 2025
2023 – 2029
United States locations
- U.S. sites
- 4
- U.S. states
- 4
- U.S. cities
- 4
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| AdventHealth | Orlando | Florida | 32804 | Recruiting |
| Louisiana State University Medical Center New Orleans | New Orleans | Louisiana | 70112 | Recruiting |
| University of New Mexico Comprehensive Cancer Center | Albuquerque | New Mexico | 87131 | Recruiting |
| Stephenson Cancer Center | Oklahoma City | Oklahoma | 73117 | Recruiting |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT05512208, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Oct 21, 2025 · Synced May 20, 2026
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Open the official record
The complete protocol, eligibility criteria, and contact information for NCT05512208 live on ClinicalTrials.gov.