A Precision Medicine Approach Using Gene Silencing to Treat a Chronic Liver Disease Called Metabolic Dysfunction-Associated Steatohepatitis (MASH) in Adult Participants at Increased Genetic Risk for This Condition

ClinicalTrials.gov ID: NCT05519475

Public ClinicalTrials.gov record NCT05519475. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.

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ClinicalTrials.gov public records Last synced May 8, 2026, 8:09 AM EDT

Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.

Official title

A Randomized, Double-Blind, Placebo-Controlled, Phase 2 Study of siRNA Gene Silencing for the Treatment of Metabolic Dysfunction-Associated Steatohepatitis (MASH) in Participants With Genetic Risk Factors

Study identification

NCT ID: NCT05519475
Recruitment status: Recruiting
Study type: Interventional
Phase: Phase 2
Lead sponsor: Regeneron Pharmaceuticals; Industry
Enrollment: 120 participants

Conditions and interventions

Conditions

Metabolic Dysfunction-Associated SteatoHepatitis (MASH)

Interventions

ALN-HSD Drug
Placebo Drug

Drug

Eligibility (public fields only)

Age range: 18 Years to 75 Years
Sex: All
Healthy volunteers: Healthy volunteers not accepted

This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.

Study timeline

Start date: Feb 8, 2023
Primary completion: Apr 26, 2028
Completion: Dec 6, 2028
Last update posted: May 6, 2026

2023 – 2028

United States locations

U.S. sites: 61
U.S. states: 14
U.S. cities: 51

Facility	City	State	ZIP	Site status
Arizona Liver Health	Chandler	Arizona	85224	Recruiting
The Institute for Liver Health II LLC DBA Arizona Clinical Trials - Flagstaff	Flagstaff	Arizona	86001	Terminated
The Institute for Liver Health II LLC DBA Arizona Liver Health - Peoria	Peoria	Arizona	85381	Recruiting
Adobe Clinical Research	Tucson	Arizona	85712	Recruiting
Arizona Liver Health - Tucson	Tucson	Arizona	85712	Recruiting
Del Sol Research Management, LLC	Tucson	Arizona	85715	Recruiting
San Fernando Valley Health Institute	Canoga Park	California	91304	Terminated
Velocity Clinical Research	Chula Vista	California	91911	Terminated
Southern California Research Center	Coronado	California	92118	Recruiting
Ark Clinical Research - Fountain Valley	Fountain Valley	California	92708	Recruiting
Velocity Clinical Research	Gardena	California	90247	Terminated
Velocity Clinical Research - Huntington Park	Huntington Park	California	90255	Terminated
Om Research Llc	Lancaster	California	93534	Recruiting
Ark Clinical Research - Long Beach	Long Beach	California	90815	Recruiting
Velocity Clinical Research - Westlake	Los Angeles	California	90057	Terminated
Clinnova Research Solutions	Orange	California	92868	Recruiting
Knowledge Research Center, St. Joseph's Medical Tower	Orange	California	92868	Recruiting
National Research Institute	Panorama City	California	91402	Terminated
California Liver Research Institute	Pasadena	California	91105	Recruiting
Cadena Care Inst.	Poway	California	92064	Terminated
Inland Empire Liver Foundation	Rialto	California	92377	Recruiting
Precision Research Institute - San Diego	San Diego	California	92114	Terminated
University of Colorado Anschutz Medical Campus	Aurora	Colorado	80045	Recruiting
Synergy Healthcare LLC	Bradenton	Florida	34209	Terminated
Evolution Clinical Trials	Hialeah Gardens	Florida	33016	Recruiting
Health Awareness, inc.	Jupiter	Florida	33458	Recruiting
Miami Clinical Research	Miami	Florida	33155	Terminated
International Medical Investigational Centers (IMIC) Incorporated	Miami	Florida	33157	Terminated
Genoma Research Group, Inc.	Miami	Florida	33173	Recruiting
US Associates in Research, LLC	Miami	Florida	33175	Terminated
Med Research of Florida, LLC	Miami	Florida	33186	Recruiting
Charter Research LLC - Orlando	Orlando	Florida	32803	Recruiting
Indiana University School of Medicine	Indianapolis	Indiana	46202	Recruiting
Deaconess Clinic - GI Specialty Center	Newburgh	Indiana	47630	Recruiting
Tandem Clinical Research	Metairie	Louisiana	70006	Recruiting
Mercy Medical Center	Baltimore	Maryland	21202	Terminated
GI Associates	Flowood	Mississippi	39232	Recruiting
Washington University School of Medicine	St Louis	Missouri	63110	Recruiting
Columbia University Irving Medical Center	New York	New York	10032	Recruiting
Geisinger Medical Center	Danville	Pennsylvania	17822	Recruiting
Penn State Health Milton S. Hershey Medical Center	Hershey	Pennsylvania	17033	Recruiting
University of Pennsylvania - Perelman Center for Advanced Medicine	Philadelphia	Pennsylvania	19104	Recruiting
Austin Clinical Research, LLC	Austin	Texas	78745	Terminated
American Research Corporation	Austin	Texas	78757	Recruiting
Pinnacle Clinical Research - Austin	Austin	Texas	78757	Recruiting
South Texas Research Institute (STRI) - Brownsville	Brownsville	Texas	78520	Recruiting
Velocity Clinical Research - Austin	Cedar Park	Texas	78613	Terminated
Methodist Dallas Medical Center	Dallas	Texas	75203	Recruiting
South Texas Research Institute (STRI) - Edinburg	Edinburg	Texas	78539	Terminated
GI Alliance Research	Fort Worth	Texas	76104	Recruiting
Allure Health at Mt. Olympus Medical Research	Friendswood	Texas	77546	Terminated
Advanced Medical Trials	Georgetown	Texas	78628	Recruiting
Pioneer Research Solutions, Inc.	Houston	Texas	77099	Recruiting
R & H Clinical Research, Inc.	Katy	Texas	77494	Terminated
Great Lakes Research Institute	Pharr	Texas	78577	Terminated
American Research Corporation at The Texas Liver Institute	San Antonio	Texas	78215	Recruiting
Pinnacle Clinical Research - San Antonio	San Antonio	Texas	78229	Recruiting
R & H Clinical Research	Stafford	Texas	77477	Terminated
Intermountain Health	Murray	Utah	84107	Terminated
University of Virginia Medical Center	Charlottesville	Virginia	22903	Recruiting
Richmond Veterans Administration Medical Center	Richmond	Virginia	23249	Recruiting

Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.

Non-U.S. locations

This page focuses on the U.S. directory. The official record also lists 10 non-U.S. sites.

About this trial record page

What this page shows: Public field values for ClinicalTrials.gov record NCT05519475, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
What this page does not do: No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
Where the data comes from: Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
Last refresh: Last update posted May 6, 2026 · Synced May 8, 2026

Open the official record

The complete protocol, eligibility criteria, and contact information for NCT05519475 live on ClinicalTrials.gov.

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