A Study to Evaluate the Safety and Efficacy of CT1812 in Early Alzheimer's Disease
Public ClinicalTrials.gov record NCT05531656. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
Synaptic Therapy Alzheimer's Research Trial (START): A Randomized, Double-Blind, Placebo-Controlled, Parallel-Group Trial to Evaluate the Safety and Efficacy of CT1812 in Early Alzheimer's Disease Over 18 Months.
Study identification
- NCT ID
- NCT05531656
- Recruitment status
- Active, not recruiting
- Study type
- Interventional
- Phase
- Phase 2
- Lead sponsor
- Cognition Therapeutics
- Industry
- Enrollment
- 540 participants
Conditions and interventions
Conditions
Interventions
- CT1812 Drug
- Placebo Drug
Drug
Eligibility (public fields only)
- Age range
- 50 Years to 85 Years
- Sex
- All
- Healthy volunteers
- Not listed
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Jun 27, 2023
- Primary completion
- Mar 31, 2027
- Completion
- Mar 31, 2027
- Last update posted
- Sep 21, 2025
2023 – 2027
United States locations
- U.S. sites
- 50
- U.S. states
- 26
- U.S. cities
- 44
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| University of Alabama at Birmingham | Birmingham | Alabama | 35294 | — |
| Banner Alzheimer's Institute | Phoenix | Arizona | 85006 | — |
| Banner Sun Health Research Institute | Sun City | Arizona | 85351 | — |
| University of California | Irvine | California | 92697 | — |
| Stanford University | Palo Alto | California | 94304 | — |
| Sutter Institute for Medical Research | Sacramento | California | 95816 | — |
| Yale University | New Haven | Connecticut | 06510 | — |
| Georgetown University | Washington D.C. | District of Columbia | 20057 | — |
| Howard University | Washington D.C. | District of Columbia | 20060 | — |
| Brain Matters Research | Delray Beach | Florida | 33445 | — |
| Neuropsychiatric Research Center of Southwest Florida | Fort Myers | Florida | 33912 | — |
| Mayo Clinic,Jacksonville | Jacksonville | Florida | 32216 | — |
| JEM Research Institute | Lake Worth | Florida | 33462 | — |
| K2 Medical Research, LLC | Maitland | Florida | 32751 | — |
| Advanced Clinical Research Network, Corp | Miami | Florida | 33135 | — |
| Charter Research | Orlando | Florida | 32803 | — |
| Headlands Research Orlando | Orlando | Florida | 32819 | — |
| Brain Matters Research Stuart | Stuart | Florida | 34997 | — |
| University of South Florida | Tampa | Florida | 33613 | — |
| Conquest Research, LLC | Winter Park | Florida | 32789 | — |
| Rush University Medical Center | Chicago | Illinois | 60612 | — |
| Indiana University | Indianapolis | Indiana | 46202 | — |
| Sanders-Brown Center on Aging | Lexington | Kentucky | 40504 | — |
| John Hopkins University | Baltimore | Maryland | 21224 | — |
| Brigham and Women's Hospital | Boston | Massachusetts | 02115 | — |
| Highlands Research Eastern MA | Plymouth | Massachusetts | 02360 | — |
| University of Michigan, Ann Arbor | Ann Arbor | Michigan | 48109 | — |
| Mayo Clinic, Rochester | Rochester | Minnesota | 55901 | — |
| Washington University School of Medicine | St Louis | Missouri | 63110 | — |
| Cleveland Clinic Lou Ruvo Center for Brain Health | Las Vegas | Nevada | 89106 | — |
| Mount Sinai School of Medicine | New York | New York | 10029 | — |
| Columbia University Medical Center | New York | New York | 10032 | — |
| University of Rochester Medical Center | Rochester | New York | 14620 | — |
| Wake Forest University Health Sciences | Winston-Salem | North Carolina | 27157 | — |
| Case Western Reserve University / University Hospitals | Beachwood | Ohio | 44122 | — |
| Ohio State University | Columbus | Ohio | 43210 | — |
| Central States Research, LLC | Tulsa | Oklahoma | 74136 | — |
| Summit Headlands LLC | Portland | Oregon | 97210 | — |
| Oregon Health & Science University | Portland | Oregon | 97239 | — |
| Abington Neurological Associates | Abington | Pennsylvania | 19001 | — |
| University of Pennsylvania | Philadelphia | Pennsylvania | 19104 | — |
| Butler Hospital | Providence | Rhode Island | 02906 | — |
| Ralph H. Johnson VA MC | Charleston | South Carolina | 29401 | — |
| Vanderbilt University Medical Center Center for Cognitive Medicine | Nashville | Tennessee | 37212 | — |
| Vanderbilt University Medical Center Center for Cognitive Medicine | Nashville | Tennessee | 37232 | — |
| University of Texas Southwestern Medical Center | Dallas | Texas | 75390 | — |
| Baylor College of Medicine | Houston | Texas | 77030 | — |
| Houston Methodist Neurological Institute | Houston | Texas | 77030 | — |
| University of Texas Health Science Center | San Antonio | Texas | 78229 | — |
| University of Wisconsin | Madison | Wisconsin | 53726 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT05531656, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Sep 21, 2025 · Synced Apr 20, 2026
Related: full search, browse by condition, browse by drug or therapy, browse by sponsor, browse by U.S. city.
Open the official record
The complete protocol, eligibility criteria, and contact information for NCT05531656 live on ClinicalTrials.gov.