Avacincaptad Pegol Open-Label Extension for Patients With Geographic Atrophy
Public ClinicalTrials.gov record NCT05536297. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
An Open-label Extension (OLE) Phase 3 Trial to Assess the Safety of Intravitreal Administration of Avacincaptad Pegol (Complement C5 Inhibitor) in Patients With Geographic Atrophy Who Previously Completed Phase 3 Study ISEE2008 (GATHER2)
Brief summary
Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.
The purpose of this study is to assess long-term safety of avacincaptad pegol intravitreal administration for patients with geographic atrophy (GA) who completed Study ISEE2008 (GATHER2) through the Month 23 visit on study treatment (either avacincaptad pegol or Sham).
Study identification
- NCT ID
- NCT05536297
- Recruitment status
- Completed
- Study type
- Interventional
- Phase
- Phase 3
- Enrollment
- 278 participants
Conditions and interventions
Eligibility (public fields only)
- Age range
- 50 Years and older
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Sep 26, 2022 (Actual)
- Primary completion
- Apr 10, 2025 (Actual)
- Completion
- Apr 10, 2025 (Actual)
- Last update posted
- May 18, 2026
2022 – 2025
United States locations
- U.S. sites
- 53
- U.S. states
- 21
- U.S. cities
- 52
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| Retinal Diagnostic Center | Campbell | California | 95008 | — |
| Eye Medical Center of Fresno | Fresno | California | 93720 | — |
| Retina Consultants of Orange County | Fullerton | California | 92835 | — |
| Jacobs Retina Center at The Shiley Eye Institute USCD | La Jolla | California | 92093 | — |
| Jules Stein Eye Institute David Geffen School of Medicine | Los Angeles | California | 90095 | — |
| Doheny Eye Center, UCLA | Pasadena | California | 91105 | — |
| Retina Consultants of Southern California | Redlands | California | 92374 | — |
| Orange County Retinal Med Group | Santa Ana | California | 92705 | — |
| University of Colorado | Aurora | Colorado | 80045 | — |
| Retina Consultants of Southern CO | Colorado Springs | Colorado | 80909 | — |
| Colorado Retina Associates, PC | Lakewood | Colorado | 80228 | — |
| Rand Eye Institute | Deerfield Beach | Florida | 33064 | — |
| Retina Group of Florida | Fort Lauderdale | Florida | 33308 | — |
| Florida Eye Associates | Melbourne | Florida | 32901 | — |
| Retina Care Specialists | Palm Beach Gardens | Florida | 33410 | — |
| Retina Associates of Sarasota | Sarasota | Florida | 34233 | — |
| Retina Vitreous Associates of Florida | St. Petersburg | Florida | 33711 | — |
| East Florida Eye Institute | Stuart | Florida | 34994 | — |
| Southern Vitreoretinal Associates | Tallahassee | Florida | 32308 | — |
| Center for Retina & Macula Disease | Winter Haven | Florida | 33880 | — |
| Southeast Retina Center P.C. | Augusta | Georgia | 30909 | — |
| Retina Consultants of Hawaii, Inc. | ‘Aiea | Hawaii | 96701 | — |
| Illinois Eye Center | Peoria | Illinois | 61615 | — |
| Vitreo Retinal Consultants & Surgeons | Wichita | Kansas | 67214 | — |
| Ochsner Clinic Foundation | New Orleans | Louisiana | 70124 | — |
| The Retina Group of Washington | Chevy Chase | Maryland | 20815 | — |
| Cumberland Valley Retina Consultants | Hagerstown | Maryland | 21740 | — |
| Ophthalmic Consultants of Boston | Boston | Massachusetts | 02114 | — |
| Retina Research Institute at New England Retina | Springfield | Massachusetts | 01107 | — |
| Vitreoretinal Associates PC | Worcester | Massachusetts | 01605 | — |
| Sierra Eye Associates | Reno | Nevada | 89502 | — |
| Retina Vitreous Surgeons of Central New York | Liverpool | New York | 13088 | — |
| Ophthalmic Consultants of Long Island | Oceanside | New York | 11572 | — |
| Retina Associates of Western NY | Rochester | New York | 14620 | — |
| Western Carolina Retinal Associates | Asheville | North Carolina | 28803 | — |
| Retina & Vitreous Center of Southern Oregon, PC | Ashland | Oregon | 97520 | — |
| Retina Northwest PC | Portland | Oregon | 97221 | — |
| Eye Health Northwest | Portland | Oregon | 97225 | — |
| Mid Atlantic Retina - Wills Eye Institute | Philadelphia | Pennsylvania | 19107 | — |
| Associates in Ophthalmology | West Mifflin | Pennsylvania | 15122 | — |
| Retina Research of Beaufort | Beaufort | South Carolina | 29902 | — |
| Palmetto Retina Center | West Columbia | South Carolina | 29169 | — |
| Black Hills Regional Eye Institute | Rapid City | South Dakota | 57701 | — |
| Southeastern Retina Associates, PC | Knoxville | Tennessee | 37922 | — |
| Retina Research Institute of Texas, LLC | Abilene | Texas | 79606 | — |
| Southwest Retina Specialists | Amarillo | Texas | 79106 | — |
| Austin Retina Associates | Austin | Texas | 78705 | — |
| Retina Foundation of the Southwest | Dallas | Texas | 75231 | — |
| Retina Center of Texas | Southlake | Texas | 76092 | — |
| Retina Consultants of Houston | The Woodlands | Texas | 77384 | — |
| Strategic Clinical Research Group, LLC | Willow Park | Texas | 76087 | — |
| Retina Associates of Utah PC | Salt Lake City | Utah | 84107 | — |
| Pacific Northwest Retina | Bellevue | Washington | 98004 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
Non-U.S. locations
This page focuses on the U.S. directory. The official record also lists 64 non-U.S. sites.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT05536297, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted May 18, 2026 · Synced Oct 19, 2026
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Open the official record
The complete public registry record, listed eligibility criteria, and available contact information for NCT05536297 live on ClinicalTrials.gov.