A Phase 2 Study of ACR-368 in Endometrial Adenocarcinoma

ClinicalTrials.gov ID: NCT05548296

Public ClinicalTrials.gov record NCT05548296. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.

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ClinicalTrials.gov public records Last synced May 8, 2026, 5:06 AM EDT

Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.

Official title

A Phase 2 Study of ACR-368 Therapy in Subjects With Endometrial Cancer

Study identification

NCT ID: NCT05548296
Recruitment status: Recruiting
Study type: Interventional
Phase: Phase 2
Lead sponsor: Acrivon Therapeutics; Industry
Enrollment: 401 participants

Conditions and interventions

Conditions

Endometrial Adenocarcinoma

Interventions

ACR-368 Drug
Gemcitabine Drug
OncoSignature Diagnostic Test

Drug · Diagnostic Test

Eligibility (public fields only)

Age range: 18 Years and older
Sex: Female
Healthy volunteers: Healthy volunteers not accepted

This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.

Study timeline

Start date: Aug 28, 2022
Primary completion: May 29, 2027
Completion: Nov 29, 2027
Last update posted: May 4, 2026

2022 – 2027

United States locations

U.S. sites: 69
U.S. states: 31
U.S. cities: 59

Facility	City	State	ZIP	Site status
University of South Alabama Mitchell Cancer Institute	Mobile	Alabama	36604	Completed
Alaska Women's Cancer Center	Anchorage	Alaska	99508	Completed
HonorHealth	Phoenix	Arizona	85016	Recruiting
Arizona Oncology Associate, PC- HOPE	Tucson	Arizona	85711	Active, not recruiting
University of Arkansas for Medical Sciences	Little Rock	Arkansas	72205	Recruiting
City of Hope National Medical Center	Duarte	California	91010	Recruiting
UC San Diego Moores Cancer Center	La Jolla	California	92037	Recruiting
USC/Norris Comprehensive Cancer Center	Los Angeles	California	90033	Completed
Cedars Sinai Medical Center	Los Angeles	California	90048	Recruiting
Hoag Cancer Center	Newport Beach	California	92663	Recruiting
UC Irvine Health	Orange	California	92868	Completed
Stanford Cancer Center	Palo Alto	California	94304	Recruiting
University of California, Davis Comprehensive Cancer Center	Sacramento	California	95817	Recruiting
University of California Los Angeles (UCLA)	Santa Monica	California	90404	Recruiting
University of Colorado	Aurora	Colorado	80045	Recruiting
Yale Cancer Center	New Haven	Connecticut	06520	Completed
Florida Gynecologic Oncology/Regional Cancer Center	Fort Myers	Florida	33905	Completed
Mount Sinai Comprehensive Cancer Center	Miami Beach	Florida	33140	Recruiting
Emory University	Atlanta	Georgia	30322	Recruiting
Northeast Georgia Medical Center	Gainesville	Georgia	30501	Completed
Northwestern Medicine	Chicago	Illinois	60611	Recruiting
University of Illinois Cancer Center	Chicago	Illinois	60612	Recruiting
University of Chicago Medicine	Chicago	Illinois	60637	Recruiting
Carle Cancer Center	Urbana	Illinois	61801	Recruiting
Ascension St. Vicent Hospital, Inc.	Indianapolis	Indiana	46260	Recruiting
University of Iowa	Iowa City	Iowa	52252	Recruiting
LSU Health Sciences	New Orleans	Louisiana	70112	Recruiting
Trials365, LLC	Shreveport	Louisiana	71103	Recruiting
American Oncology Partners of Maryland PA	Bethesda	Maryland	20817	Completed
National Institutes of Health, Clinical Center	Bethesda	Maryland	20892	Active, not recruiting
Holy Cross Hospital	Silver Spring	Maryland	20910	Completed
Dana Farber Cancer Institute	Boston	Massachusetts	02115	Recruiting
University of Massachusetts Chan Medical School	Worcester	Massachusetts	01605	Completed
Karmanos Cancer Institute	Detroit	Michigan	48201	Recruiting
HCA Midwest	Kansas City	Missouri	64132	Recruiting
John Theurer Cancer Center at Hackensack University Medical Center	Hackensack	New Jersey	07601	Recruiting
Rutgers Cancer Institute of NJ	New Brunswick	New Jersey	08903	Recruiting
Laura & Isaac Perlmutter Cancer Center	New York	New York	10016	Recruiting
New York Presbyterian Hospital-Columbia University Medical Center	New York	New York	10032	Completed
Memorial Sloan-Kettering Cancer Center	New York	New York	10065	Recruiting
Mount Sinai Health System	New York	New York	10128	Recruiting
University of Rochester Medical Center	Rochester	New York	14642	Recruiting
University of North Carolina at Chapel Hill	Chapel Hill	North Carolina	27599	Completed
FirstHealth of the Carolinas	Pinehurst	North Carolina	28374	Active, not recruiting
Gabrail Cancer Center	Canton	Ohio	44718	Completed
Miami Valley Hospital South	Centerville	Ohio	45459	Recruiting
University of Cincinnati Cancer Center	Cincinnati	Ohio	45267	Recruiting
Cleveland Clinic Foundation	Cleveland	Ohio	44195	Completed
Ohio State University	Hilliard	Ohio	43026	Recruiting
Stephenson Cancer Center at OU Health	Oklahoma City	Oklahoma	73104	Recruiting
Oncology Associates of Oregon	Eugene	Oregon	97401	Completed
Oregon Health & Sciences University	Portland	Oregon	97239	Completed
Fox Chase Cancer Center	Philadelphia	Pennsylvania	19111	Active, not recruiting
West Penn Hospital	Pittsburgh	Pennsylvania	15224	Recruiting
Women & Infants Hospital	Providence	Rhode Island	02905	Recruiting
Sanford Health	Sioux Falls	South Dakota	57104	Recruiting
Texas Oncology-Dallas Presbyterian Hospital	Dallas	Texas	75231	Completed
University of Texas Southwestern Medical Center	Dallas	Texas	75390	Completed
Texas Oncology	Fort Worth	Texas	76104	Completed
University of Texas, MD Anderson Cancer Center	Houston	Texas	77030	Recruiting
Huntsman Cancer Institute, University of Utah	Salt Lake City	Utah	84112	Recruiting
University of Virginia Health System	Charlottesville	Virginia	22903	Recruiting
Virginia Commonwealth University	Richmond	Virginia	23298	Recruiting
Swedish Cancer Center	Seattle	Washington	98104	Recruiting
Fred Hutchinson Cancer Center	Seattle	Washington	98109	Completed
Providence Sacred Heart Medical Center and Children's Hospital	Spokane	Washington	99204	Recruiting
Summit Cancer Center	Spokane	Washington	99208	Completed
Northwest Cancer Specialists, P.C.	Vancouver	Washington	98684	Completed
Froedtert and Medical College of Wisconsin	Milwaukee	Wisconsin	53226	Recruiting

Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.

Non-U.S. locations

This page focuses on the U.S. directory. The official record also lists 21 non-U.S. sites.

About this trial record page

What this page shows: Public field values for ClinicalTrials.gov record NCT05548296, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
What this page does not do: No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
Where the data comes from: Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
Last refresh: Last update posted May 4, 2026 · Synced May 8, 2026

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The complete protocol, eligibility criteria, and contact information for NCT05548296 live on ClinicalTrials.gov.

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