Tebentafusp Regimen Versus Investigator's Choice in Previously Treated Advanced Melanoma (TEBE-AM)
Public ClinicalTrials.gov record NCT05549297. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
Phase 2/3 Randomized Study of Tebentafusp as Monotherapy and in Combination With Pembrolizumab Versus Investigator's Choice in HLA-A*02:01-positive Participants With Previously Treated Advanced Melanoma (TEBE-AM)
Study identification
- NCT ID
- NCT05549297
- Recruitment status
- Recruiting
- Study type
- Interventional
- Phase
- Phase 3
- Lead sponsor
- Immunocore Ltd
- Industry
- Enrollment
- 540 participants
Conditions and interventions
Conditions
Interventions
- Investigators Choice Drug
- Tebentafusp Drug
- Tebentafusp with Pembrolizumab Drug
Drug
Eligibility (public fields only)
- Age range
- 18 Years and older
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Dec 18, 2022
- Primary completion
- Feb 29, 2028
- Completion
- Jun 30, 2028
- Last update posted
- Feb 24, 2026
2022 – 2028
United States locations
- U.S. sites
- 25
- U.S. states
- 18
- U.S. cities
- 22
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| Mayo Clinic Arizona | Phoenix | Arizona | 85054 | Recruiting |
| Mayo Clinic Florida | Jacksonville | Florida | 32224 | Recruiting |
| Orlando Health Cancer Institute | Orlando | Florida | 32806 | Recruiting |
| Winship Cancer Institute of Emory University | Atlanta | Georgia | 30322 | Recruiting |
| University of Kansas Cancer Center - Westwood | Westwood | Kansas | 66205 | Recruiting |
| St Elizabeth Healthcare (St Elizabeth Medical Center) | Edgewood | Kentucky | 41017 | Recruiting |
| St Elizabeth Healthcare (St Elizabeth Medical | Edgewood | Kentucky | 41017 | Recruiting |
| Massachusetts General Hospital | Boston | Massachusetts | 02114 | Recruiting |
| Beth Israel Deaconess Medical Center (BIDMC) | Boston | Massachusetts | 02215 | Recruiting |
| Dana Farber Cancer Institute | Boston | Massachusetts | 02215 | Recruiting |
| University of Minnesota Medical Center | Minneapolis | Minnesota | 55455 | Recruiting |
| Mayo Clinic Minnesota | Rochester | Minnesota | 55905 | Recruiting |
| Washington University School of Medicine | St Louis | Missouri | 63110 | Recruiting |
| Rutgers Cancer Institute of New Jersey | New Brunswick | New Jersey | 08901 | Recruiting |
| Northwell Health Cancer Institute - Zuckerberg Cancer Center | Lake Success | New York | 11042 | Recruiting |
| Memorial Sloan Kettering Cancer Center | New York | New York | 10068 | Recruiting |
| The Ohio State University Comprehensive Cancer Center | Columbus | Ohio | 43210 | Recruiting |
| OU Health Stephenson Cancer Center | Oklahoma City | Oklahoma | 73104 | Recruiting |
| Thomas Jefferson University Medical Oncology Clinic | Philadelphia | Pennsylvania | 19107 | Recruiting |
| UPMC Hillman Cancer Center | Pittsburgh | Pennsylvania | 15232 | Recruiting |
| Gibbs Cancer Center and Research Institute | Spartanburg | South Carolina | 29303 | Recruiting |
| University of Tennessee Medical Center | Knoxville | Tennessee | 37920 | Recruiting |
| Houston Methodist Hospital/Houston Methodist Cancer Center | Houston | Texas | 77030 | Recruiting |
| University of Utah Huntsman Cancer Institute | Salt Lake City | Utah | 84112 | Recruiting |
| Fred Hutchinson Cancer Center | Seattle | Washington | 98109 | Recruiting |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
Non-U.S. locations
This page focuses on the U.S. directory. The official record also lists 57 non-U.S. sites.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT05549297, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Feb 24, 2026 · Synced May 6, 2026
Related: full search, browse by condition, browse by drug or therapy, browse by sponsor, browse by U.S. city.
Open the official record
The complete protocol, eligibility criteria, and contact information for NCT05549297 live on ClinicalTrials.gov.