A Study of Aticaprant 10 Milligrams (mg) as Adjunctive Therapy in Adult Participants With MDD With Moderate-to-severe Anhedonia and Inadequate Response to Current Antidepressant Therapy
Public ClinicalTrials.gov record NCT05550532. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
A Randomized, Double-blind, Multicenter, Parallel-group, Placebo-controlled Study to Evaluate the Efficacy, Safety, and Tolerability of Aticaprant 10 mg as Adjunctive Therapy in Adult Participants With Major Depressive Disorder (MDD) With Moderate-to-severe Anhedonia and Inadequate Response to Current Antidepressant Therapy
Brief summary
Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.
The purpose of this study is to evaluate the efficacy of aticaprant compared with placebo as adjunctive therapy to an antidepressant in improving depressive symptoms in adult participants with major depressive disorder (MDD) with moderate to severe anhedonia (ANH+) who have had an inadequate response to current antidepressant therapy with a selective serotonin reuptake inhibitor (SSRI) or serotonin-norepinephrine reuptake inhibitor (SNRI).
Study identification
- NCT ID
- NCT05550532
- Recruitment status
- Completed
- Study type
- Interventional
- Phase
- Phase 3
- Enrollment
- 444 participants
Conditions and interventions
Conditions
Eligibility (public fields only)
- Age range
- 18 Years to 74 Years
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Dec 6, 2022 (Actual)
- Primary completion
- Nov 8, 2024 (Actual)
- Completion
- Nov 13, 2024 (Actual)
- Last update posted
- Feb 13, 2026
2022 – 2024
United States locations
- U.S. sites
- 51
- U.S. states
- 19
- U.S. cities
- 43
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| University of Alabama at Birmingham | Birmingham | Alabama | 35205 | — |
| Sunwise Clinical Research | Lafayette | California | 94549 | — |
| Pacific Neuropsychiatric Specialists | Orange | California | 92868 | — |
| Prospective Research Innovations Inc | Rancho Cucamonga | California | 91730 | — |
| University of California San Diego Medical Center | San Diego | California | 92103 | — |
| CMB Clinical Trials | Santee | California | 92071 | — |
| California Neuroscience Research | Sherman Oaks | California | 91403 | — |
| Pacific Clinical Research Medical Group | Upland | California | 91786 | — |
| Next Level Clinical Trials, LLC | West Covina | California | 91790 | — |
| MCB Clinical Research Centers LLC | Colorado Springs | Colorado | 80910 | — |
| CNS Clinical Research Group | Coral Springs | Florida | 33067 | — |
| Sarkis Clinical Trials | Gainesville | Florida | 32607 | — |
| New Life Medical Research Center, Inc. | Hialeah | Florida | 33012 | — |
| K2 Medical Research | Maitland | Florida | 32751 | — |
| Vital Care Research | Miami | Florida | 33122 | — |
| Global Medical Institutes | Miami | Florida | 33125 | — |
| LCC Medical Research Institute Inc | Miami | Florida | 33126 | — |
| Florida Research Center Inc. | Miami | Florida | 33174 | — |
| Ezy Medical Research | Miami | Florida | 33175 | — |
| Felicidad Medical Research | Miami | Florida | 33184 | — |
| Bravo Health Care Center | North Bay Village | Florida | 33141 | — |
| APG Research LLC | Orlando | Florida | 32803 | — |
| Combined Research Orlando | Orlando | Florida | 32803 | — |
| Quantum Laboratories | Pompano Beach | Florida | 33064 | — |
| CDC Research Institute LLC | Port Saint Lucie | Florida | 34952 | — |
| Psychiatric Medicine Associates | Skokie | Illinois | 60076 | — |
| Tandem Clinical Research | Marrero | Louisiana | 70072 | — |
| CBH Health | Gaithersburg | Maryland | 20877 | — |
| Michigan Clinical Research Institute | Ann Arbor | Michigan | 48105 | — |
| Revive Research Institute | Farmington Hills | Michigan | 48334 | — |
| Midwest Research Group | Saint Charles | Missouri | 63304 | — |
| Premier Psychiatric Research Institute, LLC | Lincoln | Nebraska | 68526 | — |
| Erie County Medical Center | Buffalo | New York | 14215 | — |
| Manhattan Behavioral Medicine | New York | New York | 10036 | — |
| New Hope Clinical Research | Charlotte | North Carolina | 28211 | — |
| Monroe Biomedical Research | Monroe | North Carolina | 28112 | — |
| The Cleveland Clinic Foundation | Cleveland | Ohio | 44195 | — |
| Wexner Medical Center at the Ohio State University | Columbus | Ohio | 43221 | — |
| Conrad Clinical Research | Edmond | Oklahoma | 73013 | — |
| Sooner Clinical Research | Oklahoma City | Oklahoma | 73112 | — |
| Paradigm Research Professionals, LLC | Oklahoma City | Oklahoma | 73118 | — |
| Lehigh Center for Clinical Research LLC | Allentown | Pennsylvania | 18103 | — |
| Global Medical Institutes | Moosic | Pennsylvania | 18507 | — |
| Clinical Trials of South Carolina | Charleston | South Carolina | 29406 | — |
| Donald J Garcia Jr MD PA | Austin | Texas | 78737 | — |
| Relaro Medical Trials | Dallas | Texas | 75243 | — |
| UT Southwestern Medical Center | Dallas | Texas | 75247-9119 | — |
| R and H Clinical Research | Stafford | Texas | 77477 | — |
| Cedar Psychiatry | Murray | Utah | 84107 | — |
| Northwest Clinical Research Center | Bellevue | Washington | 98007 | — |
| Core Clinical Research | Everett | Washington | 98201 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
Non-U.S. locations
This page focuses on the U.S. directory. The official record also lists 80 non-U.S. sites.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT05550532, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Feb 13, 2026 · Synced Oct 23, 2026
Related: full search, browse by condition, browse by drug or therapy, browse by sponsor, browse by U.S. city.
Open the official record
The complete public registry record, listed eligibility criteria, and available contact information for NCT05550532 live on ClinicalTrials.gov.