ClinicalTrials.gov record
Open-label Extension for Phase 3 Clinical Trials of Simufilam
ClinicalTrials.gov ID: NCT05575076
Public ClinicalTrials.gov record NCT05575076. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
An Open-label, Long-term Extension Study to Evaluate the Safety and Tolerability of Simufilam 100 mg Tablets in Participants With Mild to Moderate Alzheimer's Disease
Brief summary
Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.
The goal of this open-label extension study is to assess long-term safety and tolerability of simufilam 100 mg in subjects who have completed the RETHINK-ALZ or REFOCUS-ALZ Phase 3 clinical trials.
Study identification
- NCT ID
- NCT05575076
- Recruitment status
- Terminated
- Study type
- Interventional
- Phase
- Phase 3
- Enrollment
- 1,081 participants
Conditions and interventions
Conditions
Eligibility (public fields only)
- Age range
- 51 Years to 89 Years
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Nov 7, 2022 (Actual)
- Primary completion
- Jan 31, 2025 (Actual)
- Completion
- Jan 31, 2025 (Actual)
- Last update posted
- May 23, 2025
2022 – 2025
United States locations
- U.S. sites
- 107
- U.S. states
- 26
- U.S. cities
- 97
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| MDFirst Research | Chandler | Arizona | 85286 | — |
| CCT Research - Gilbert Neurology Partners | Gilbert | Arizona | 85297 | — |
| Xenoscience, Inc. | Phoenix | Arizona | 85004 | — |
| Banner Alzheimer's Institute | Phoenix | Arizona | 85006 | — |
| Banner Sun Health Research Institute | Sun City | Arizona | 85351 | — |
| Advanced Research Center, Inc. | Anaheim | California | 92805 | — |
| North County Neurology Associates | Carlsbad | California | 92011 | — |
| Axiom Research, LLC | Colton | California | 92324 | — |
| ATP Clinical Research, Inc. | Costa Mesa | California | 92626 | — |
| Neuro-Pain Medical Center | Fresno | California | 93710 | — |
| Neurology Center of North Orange County | Fullerton | California | 92835 | — |
| Sun Valley Research Center, Inc. | Imperial | California | 92251 | — |
| Senior Clinical Trials | Laguna Hills | California | 92653 | — |
| Shankle Clinic and Hoag Memorial Hospital Presbyterian | Newport Beach | California | 92663 | — |
| Artemis Institute for Clinical Research | Riverside | California | 92503 | — |
| Pacific Research Network, LLC | San Diego | California | 92103 | — |
| Syrentis Clinical Research | Santa Ana | California | 92705 | — |
| Mountain Neurological Research Center | Basalt | Colorado | 81621 | — |
| Colorado Neurological Research Center, PC | Denver | Colorado | 80210 | — |
| Ki Health Partners, LLC | Stamford | Connecticut | 06905 | — |
| JEM Research Institute | Atlantis | Florida | 33462 | — |
| Neurology Offices of South Florida | Boca Raton | Florida | 33428 | — |
| K2 Medical Research- Ocoee | Clermont | Florida | 34711 | — |
| Arrow Clinical Trials | Daytona Beach | Florida | 32117 | — |
| Brain Matters Research | Delray Beach | Florida | 33445 | — |
| Neuropsychiatric Research Center of Southwest Florida | Fort Myers | Florida | 33912 | — |
| Velocity Clinical Research, Hallandale Beach | Hallandale | Florida | 33009 | — |
| Galiz Research | Hialeah | Florida | 33016 | — |
| Infinity Clinical Research - Sunrise | Hollywood | Florida | 33024 | — |
| Luminous Clinical Research | Homestead | Florida | 33030 | — |
| CNS Healthcare - Jacksonville | Jacksonville | Florida | 32256 | — |
| Charter Research | Lady Lake | Florida | 32792 | — |
| ClinCloud | Maitland | Florida | 32751 | — |
| Merritt Island Medical Research, LLC | Merritt Island | Florida | 32952 | — |
| Central Miami Medical Institute (GMI) | Miami | Florida | 33125 | — |
| Mind Institute at Miami Jewish Health | Miami | Florida | 33137 | — |
| New Horizon Research Center | Miami | Florida | 33165 | — |
| Brainstorm Research | Miami | Florida | 33176 | — |
| South Florida Research Phase I-IV INC | Miami Springs | Florida | 33166 | — |
| Suncoast Clinical Research, Inc. | New Port Richey | Florida | 34652 | — |
| Renstar Medical Research | Ocala | Florida | 34470 | — |
| Health Synergy Clinical Research | Okeechobee | Florida | 34972 | — |
| Clinical Neuroscience Solutions, Inc. dba CNS Healthcare | Orlando | Florida | 32801 | — |
| Medical Research | Port Orange | Florida | 32127 | — |
| Intercoastal Medical Group - Sarasota | Sarasota | Florida | 34239 | — |
| Alzheimer's Research & Treatment Center | Stuart | Florida | 34997 | — |
| Clinical Research of Brandon, LLC (Tampa) | Tampa | Florida | 33603 | — |
| Stedman Clinical Trials | Tampa | Florida | 33613 | — |
| Alzheimer's Research & Treatment Center | Wellington | Florida | 33414 | — |
| Premier Research Institute at Palm Beach Neurology | West Palm Beach | Florida | 33407 | — |
| Charter Research | Winter Park | Florida | 32792 | — |
| Columbus Memory Center, PC | Columbus | Georgia | 31909 | — |
| Accel Research Sites - NeuroStudies | Decatur | Georgia | 30030 | — |
| Velocity Clinical Research - Boise | Meridian | Idaho | 83642 | — |
| Advocate Aurora Health - Advocate Memory Center | Park Ridge | Illinois | 60068 | — |
| Ascension Via Christi Research | Wichita | Kansas | 67214 | — |
| University of Kentucky | Lexington | Kentucky | 40504 | — |
| Neuro Medical Clinic of Central Louisiana, LLC | Alexandria | Louisiana | 71301 | — |
| Neurology Center of New England | Foxborough | Massachusetts | 02035 | — |
| ActivMed Practices & Research, LLC | Methuen | Massachusetts | 01844 | — |
| Boston Center for Memory | Newton | Massachusetts | 02459 | — |
| Boston Neuro Research Center | North Dartmouth | Massachusetts | 02747 | — |
| Headlands Eastern MA LLC | Plymouth | Massachusetts | 02360 | — |
| MedVadis Research | Waltham | Massachusetts | 02451 | — |
| Clinical Research Professionals | Chesterfield | Missouri | 63005 | — |
| CCT Research - Papillion Research Center | Papillion | Nebraska | 68046 | — |
| Patient First MD | Middletown | New Jersey | 07748 | — |
| Advanced Clinical Institute, Inc | Neptune City | New Jersey | 07753 | — |
| Global Medical Institutes, LLC | Princeton | New Jersey | 08540 | — |
| The Cognitive and Research Center of New Jersey (CRCNJ) | Springfield | New Jersey | 07081 | — |
| Advanced Memory Research Institute of NJ | Toms River | New Jersey | 08755 | — |
| Neurology Specialists of Monmouth County | West Long Branch | New Jersey | 07764 | — |
| Albuquerque Neuroscience, Inc | Albuquerque | New Mexico | 87109 | — |
| Albany Medical Center | Albany | New York | 12208 | — |
| Neurological Associates of Albany | Albany | New York | 12208 | — |
| Dent Neurologic Institute | Amherst | New York | 14226 | — |
| Integrative Clinical Trials, LLC | Brooklyn | New York | 11229 | — |
| SPRI Clinical Trials Brooklyn | Brooklyn | New York | 11235 | — |
| Velocity Clinical Research, Formerly Clarity Clinical Research | East Syracuse | New York | 13057 | — |
| Parker Jewish Institute for Health Care & Rehabilitation | New Hyde Park | New York | 11040-1433 | — |
| Mid Hudson Medical Research | New Windsor | New York | 12553 | — |
| NY Neurology Associates | New York | New York | 10003 | — |
| University of Rochester Medical Center - Alzheimer's Disease Care, Research and Education Program | Rochester | New York | 14620 | — |
| Richmond Behavioral Associates | Staten Island | New York | 10312 | — |
| Richmond Behavioral Associates | Staten Island | New York | 10314 | — |
| Triad Clinical Trials, LLC | Greensboro | North Carolina | 27410 | — |
| Alzheimer's Memory Center | Matthew | North Carolina | 28105 | — |
| Accellacare Research of Winston-Salem | Winston-Salem | North Carolina | 27103 | — |
| Insight Clinical Trials LLC | Beachwood | Ohio | 44122 | — |
| NeuroScience Research Center, LLC | Canton | Ohio | 44718 | — |
| Dayton Center for Neurological Disorders | Centerville | Ohio | 45459 | — |
| the Ohio State University | Columbus | Ohio | 43221 | — |
| Neurology Diagnostics | Dayton | Ohio | 45459 | — |
| Neuro-Behavioral Clinical Research | North Canton | Ohio | 44720 | — |
| Summit Research Network, LLC | Portland | Oregon | 97210 | — |
| Center for Cognitive Health - Portland | Portland | Oregon | 97225 | — |
| Keystone Clinical Studies, LLC | Plymouth Meeting | Pennsylvania | 19462 | — |
| Rhode Island Mood & Memory Research Institute | East Providence | Rhode Island | 02914 | — |
| Palmetto Clinical Research | Summerville | South Carolina | 29485 | — |
| Senior Adults Specialty Research, Inc | Austin | Texas | 78757 | — |
| Texas Neurology, PA | Dallas | Texas | 75206 | — |
| Baylor Scott & White Research Institute | Dallas | Texas | 75231 | — |
| Mt. Olympus Medical Research, LLC | Katy | Texas | 77450 | — |
| Grayline Research Center | Wichita Falls | Texas | 76309 | — |
| Re:Cognition Health | Fairfax | Virginia | 22031 | — |
| Northwest Clinical Research Center | Bellevue | Washington | 98007 | — |
| Memory and Brain Wellness Center at Harborview | Seattle | Washington | 98104 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
Non-U.S. locations
This page focuses on the U.S. directory. The official record also lists 27 non-U.S. sites.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT05575076, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted May 23, 2025 · Synced Oct 20, 2026
Related: full search, browse by condition, browse by drug or therapy, browse by sponsor, browse by U.S. city.
Open the official record
The complete public registry record, listed eligibility criteria, and available contact information for NCT05575076 live on ClinicalTrials.gov.