A Single-Arm Phase II Study of Neoadjuvant Intensified Androgen Deprivation (Leuprolide and Abiraterone Acetate) in Combination With AKT Inhibition (Capivasertib) for High-Risk Localized Prostate Cancer With PTEN Loss
Public ClinicalTrials.gov record NCT05593497. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
Precision Neoadjuvant Therapy for High Risk Localized Prostate Cancer With PTEN Loss
Study identification
- NCT ID
- NCT05593497
- Recruitment status
- Recruiting
- Study type
- Interventional
- Phase
- Phase 2
- Lead sponsor
- VA Office of Research and Development
- Federal
- Enrollment
- 30 participants
Conditions and interventions
Conditions
Interventions
- Capivasertib Drug
- abiraterone acetate Drug
Drug
Eligibility (public fields only)
- Age range
- 18 Years and older
- Sex
- Male
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- May 30, 2024
- Primary completion
- Apr 30, 2027
- Completion
- Jul 31, 2027
- Last update posted
- Mar 26, 2026
2024 – 2027
United States locations
- U.S. sites
- 6
- U.S. states
- 6
- U.S. cities
- 6
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| VA Greater Los Angeles Healthcare System, West Los Angeles, CA | West Los Angeles | California | 90073-1003 | Recruiting |
| James J. Peters VA Medical Center, Bronx, NY | The Bronx | New York | 10468-3904 | Recruiting |
| VA Portland Health Care System, Portland, OR | Portland | Oregon | 97207-2964 | Recruiting |
| Ralph H. Johnson VA Medical Center, Charleston, SC | Charleston | South Carolina | 29401-5703 | Recruiting |
| South Texas Health Care System, San Antonio, TX | San Antonio | Texas | 78229-4404 | Terminated |
| VA Puget Sound Health Care System Seattle Division, Seattle, WA | Seattle | Washington | 98108-1532 | Recruiting |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT05593497, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Mar 26, 2026 · Synced May 13, 2026
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Open the official record
The complete protocol, eligibility criteria, and contact information for NCT05593497 live on ClinicalTrials.gov.