TArgeting Type 1 Diabetes Using POLyamines (TADPOL)
Public ClinicalTrials.gov record NCT05594563. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
TArgeting Type 1 Diabetes Using POLyamines (TADPOL): A Randomized, Double-Masked, Placebo-Controlled Phase 2 Study to Evaluate the Efficacy and Safety of Difluoromethylornithine (DFMO) to Preserve Insulin Production in Type 1 Diabetes
Study identification
- NCT ID
- NCT05594563
- Recruitment status
- Recruiting
- Study type
- Interventional
- Phase
- Phase 2
- Lead sponsor
- Emily K. Sims
- Other
- Enrollment
- 81 participants
Conditions and interventions
Conditions
Interventions
- DFMO Drug
- Placebo Drug
Drug
Eligibility (public fields only)
- Age range
- 4 Years to 40 Years
- Sex
- All
- Healthy volunteers
- Not listed
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Mar 13, 2023
- Primary completion
- Nov 30, 2027
- Completion
- Apr 30, 2028
- Last update posted
- Apr 19, 2026
2023 – 2028
United States locations
- U.S. sites
- 7
- U.S. states
- 7
- U.S. cities
- 7
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| Barbara Davis Center | Aurora | Colorado | 80045 | Recruiting |
| University of Chicago | Chicago | Illinois | 60637 | Recruiting |
| IU Health Riley Hospital for Children | Indianapolis | Indiana | 46202 | Recruiting |
| Children's Mercy Hospital | Kansas City | Kansas | 64108 | Recruiting |
| University of Michigan | Ann Arbor | Michigan | 48109 | Recruiting |
| MHealth Fairview Masonic Children's Hospital and Specialty Clinics | Minneapolis | Minnesota | 55454 | Recruiting |
| Medical College of Wisconsin | Milwaukee | Wisconsin | 53226 | Recruiting |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT05594563, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Apr 19, 2026 · Synced Apr 22, 2026
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Open the official record
The complete protocol, eligibility criteria, and contact information for NCT05594563 live on ClinicalTrials.gov.