RECOVER-VITAL: Platform Protocol to Measure the Effects of Antiviral Therapies on Long COVID Symptoms
Public ClinicalTrials.gov record NCT05595369. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
RECOVER-VITAL: A Platform Protocol for Evaluation of Interventions for Viral Persistence, Viral Reactivation, and Immune Dysregulation in Post-Acute Sequelae of SARS-CoV-2 Infection (PASC)
Brief summary
Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.
This study is a platform protocol designed to be flexible so that it is suitable for a wide range of settings within health care systems and in community settings where it can be integrated into COVID-19 programs and subsequent treatment plans. This protocol is a prospective, multi-center, multi-arm, double-blind, randomized, controlled platform trial with different interventions organized as appendices to the protocol. Each appendix (or sub-study) evaluates potential mechanisms of action, efficacy, and safety of antivirals and other therapeutics in individuals with PASC, according to the platform protocol objectives. The hypothesis is that persistent viral infection, viral reactivation, and/or overactive/chronic immune response and inflammation are underlying contributors to PASC and that antiviral and other applicable therapies may result in viral clearance or decreased inflammation and improvement in PASC symptoms.
Study identification
- NCT ID
- NCT05595369
- Recruitment status
- Completed
- Study type
- Interventional
- Phase
- Phase 2
- Enrollment
- 963 participants
Conditions and interventions
Conditions
Interventions
- Experimental: Paxlovid 25 day dosing Drug
- Experimental: Paxlovid 15 day dosing Drug
- Placebo Comparator: Control Drug
Drug
Eligibility (public fields only)
- Age range
- 18 Years and older
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Jul 26, 2023 (Actual)
- Primary completion
- Aug 6, 2024 (Actual)
- Completion
- Mar 13, 2025 (Actual)
- Last update posted
- Dec 2, 2025
2023 – 2025
United States locations
- U.S. sites
- 68
- U.S. states
- 33
- U.S. cities
- 54
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| University of Alabama at Birmingham | Birmingham | Alabama | 35205 | — |
| University of Arizona/Banner University Medical Center Phoenix | Phoenix | Arizona | 85006 | — |
| University of Arizona Banner Medical Center | Tucson | Arizona | 85719 | — |
| Cedars Sinai Medical Center | Los Angeles | California | 90048 | — |
| Hoag Memorial Hospital | Newport Beach | California | 92663 | — |
| University of California San Francisco General Hospital | San Francisco | California | 94110 | — |
| Stanford University | Stanford | California | 94305 | — |
| Los Angeles Biomedical Institute at Harbor-UCLA Medical Center | Torrance | California | 90502 | — |
| University of Colorado | Aurora | Colorado | 80045 | — |
| Howard University Hospital | Washington D.C. | District of Columbia | 20060 | — |
| University of Florida College of Medicine Jacksonville | Jacksonville | Florida | 32206 | — |
| Lakeland Regional Medical Center | Lakeland | Florida | 33805 | — |
| Valencia Medical and Research Center | Miami | Florida | 33165 | — |
| Grady Memorial Hospital | Atlanta | Georgia | 30303 | — |
| Kaiser Permanente Southwood | Atlanta | Georgia | 30305 | — |
| Morehouse School of Medicine | Atlanta | Georgia | 30310 | — |
| Atlanta VA Medical Center | Atlanta | Georgia | 45267 | — |
| Emory Health Care | Decatur | Georgia | 30030 | — |
| Northwestern Memorial Hospital | Chicago | Illinois | 60611 | — |
| Rush University Medical Center | Chicago | Illinois | 60612 | — |
| University of Illinois at Chicago | Chicago | Illinois | 60612 | — |
| North Shore University Health System | Evanston | Illinois | 60201 | — |
| Koch Family Medicine | Morton | Illinois | 61550 | — |
| Methodist Medical Center of Illinois | Peoria | Illinois | 61603 | — |
| Saint Francis Medical Center | Peoria | Illinois | 61637 | — |
| University of Kansas Medical Center | Kansas City | Kansas | 66160 | — |
| University of Kentucky Chandler Medical Center | Lexington | Kentucky | 40536 | — |
| Johns Hopkins Hospital | Baltimore | Maryland | 21287 | — |
| Jadestone Clinical Research, LLC | Silver Spring | Maryland | 20904 | — |
| Tufts Medical Center | Boston | Massachusetts | 02111 | — |
| Brigham and Womens Hospital | Boston | Massachusetts | 02115 | — |
| Boston Medical Center | Boston | Massachusetts | 02118 | — |
| Beth Israel Deaconess Medical Center | Boston | Massachusetts | 02215 | — |
| Mayo Clinic | Rochester | Minnesota | 55905 | — |
| University of Mississippi Medical Center | Jackson | Mississippi | 39216 | — |
| Washington University School of Medicine | St Louis | Missouri | 63110 | — |
| Dartmouth Hitchcock Medical Center | Lebanon | New Hampshire | 03756 | — |
| Rutgers University-Robert Wood Johnson Medical School | New Brunswick | New Jersey | 08901 | — |
| University of New Mexico Health Science Center | Albuquerque | New Mexico | 87106 | — |
| NYU Langone Health/Brooklyn Hospital | Brooklyn | New York | 11220 | — |
| St. Lawrence Health Medical Campus | Canton | New York | 13676 | — |
| Icahn School of Medicine at Mount Sinai | New York | New York | 10029 | — |
| Weil Cornell Medicine | New York | New York | 10065 | — |
| University of North Carolina | Chapel Hill | North Carolina | 27599 | — |
| East Carolina University | Greenville | North Carolina | 27834 | — |
| Duke Clinical and Translational Science Institute | Kannapolis | North Carolina | 28081 | — |
| Wake Forest University | Winston-Salem | North Carolina | 27103 | — |
| Lillestol Research, LLC | Fargo | North Dakota | 58104 | — |
| University of Cincinnati Medical Center | Cincinnati | Ohio | 45267 | — |
| University Hospitals Cleveland Medical Center | Cleveland | Ohio | 44106 | — |
| MetroHealth System | Cleveland | Ohio | 44109 | — |
| Cleveland Clinic | Cleveland | Ohio | 44195 | — |
| Oklahoma Clinical and Translational Science Institute | Oklahoma City | Oklahoma | 73104 | — |
| Oregon Health and Science University | Portland | Oregon | 97239 | — |
| UPMC Presbyterian Shadyside | Pittsburgh | Pennsylvania | 15213 | — |
| Avera McKennan Hospital & University Health Center | Sioux Falls | South Dakota | 57108 | — |
| Clinical Trials Center of Middle Tennessee | Franklin | Tennessee | 37067 | — |
| Houston Methodist Hospital | Houston | Texas | 77030 | — |
| University of Texas Health Science Center at Houston | Houston | Texas | 77030 | — |
| University of Texas Health Science Center at San Antonio | San Antonio | Texas | 78229 | — |
| Vermont Lung Center, University of Vermont | Colchester | Vermont | 05446 | — |
| University of Virginia | Charlottesville | Virginia | 22903 | — |
| Sentara Norfolk General Hospital | Norfolk | Virginia | 23507 | — |
| Swedish Health Services | Seattle | Washington | 98104 | — |
| University of Washington | Seattle | Washington | 98109 | — |
| Providence Medical Research Center | Spokane | Washington | 99204 | — |
| West Virginia Clinical and Translational Science Institute | Morgantown | West Virginia | 26506 | — |
| Froedtert Hospital-Medical College of Wisconsin | Milwaukee | Wisconsin | 53226 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
Non-U.S. locations
This page focuses on the U.S. directory. The official record also lists 1 non-U.S. site.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT05595369, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Dec 2, 2025 · Synced Oct 21, 2026
Related: full search, browse by condition, browse by drug or therapy, browse by sponsor, browse by U.S. city.
Open the official record
The complete public registry record, listed eligibility criteria, and available contact information for NCT05595369 live on ClinicalTrials.gov.