Study to Compare Axicabtagene Ciloleucel With Standard of Care Therapy as First-line Treatment in Participants With High-risk Large B-cell Lymphoma
Public ClinicalTrials.gov record NCT05605899. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
An Adaptive Phase 3, Randomized, Open-Label, Multicenter Study to Compare the Efficacy and Safety of Axicabtagene Ciloleucel Versus Standard of Care Therapy as First-Line Therapy in Subjects With High-Risk Large B-Cell Lymphoma (ZUMA-23)
Study identification
- NCT ID
- NCT05605899
- Recruitment status
- Active, not recruiting
- Study type
- Interventional
- Phase
- Phase 3
- Lead sponsor
- Kite, A Gilead Company
- Industry
- Enrollment
- 300 participants
Conditions and interventions
Conditions
Interventions
- Axicabtagene Ciloleucel Biological
- Cyclophosphamide Drug
- Doxorubicin Drug
- Etoposide Drug
- Fludarabine Drug
- Prednisone Drug
- Rituximab Drug
- Vincristine Drug
Biological · Drug
Eligibility (public fields only)
- Age range
- 18 Years and older
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Feb 9, 2023
- Primary completion
- Feb 28, 2031
- Completion
- Feb 28, 2031
- Last update posted
- Apr 14, 2026
2023 – 2031
United States locations
- U.S. sites
- 32
- U.S. states
- 23
- U.S. cities
- 29
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| University of Alabama Hospital | Birmingham | Alabama | 35233 | — |
| Banner MD Anderson Cancer Center | Gilbert | Arizona | 85234 | — |
| Mayo Clinic | Phoenix | Arizona | 85054 | — |
| UC San Diego Moores Cancer Center | La Jolla | California | 92093 | — |
| University of California Los Angeles (UCLA) | Los Angeles | California | 90095 | — |
| Colorado Blood Cancer Institute | Denver | Colorado | 80218 | — |
| Moffitt Cancer Center | Tampa | Florida | 33612 | — |
| Georgia Cancer Center at Augusta University | Augusta | Georgia | 30912 | — |
| Northwestern Memorial Hospital | Chicago | Illinois | 60612 | — |
| University of Chicago Medical Center | Chicago | Illinois | 60637 | — |
| University of Iowa | Iowa City | Iowa | 52242 | — |
| The University of Kansas Hospital | Westwood | Kansas | 66205 | — |
| Norton Cancer Institute, St. Matthews Campus | Shelbyville | Kentucky | 40065 | — |
| Ochsner Clinic Foundation | New Orleans | Louisiana | 70121 | — |
| University of MD Greenebaum Comprehensive Cancer Center | Baltimore | Maryland | 21201 | — |
| Dana-Farber Cancer Institute | Boston | Massachusetts | 02215 | — |
| University of Michigan | Ann Arbor | Michigan | 48109 | — |
| Mayo Clinic Cancer Center Outpatient Pharmacy | Rochester | Minnesota | 55902 | — |
| John Theurer Cancer Center at Hackensack University Medical Center | Hackensack | New Jersey | 07601 | — |
| Roswell Park Cancer Institute | Buffalo | New York | 14203 | — |
| Weill Cornell Medical College - NewYork Presbyterian Hospital | New York | New York | 10021 | — |
| Columbia University Medical Center | New York | New York | 10032 | — |
| University of Rochester Medical Center | Rochester | New York | 14642 | — |
| Montefiore Medical Center | The Bronx | New York | 10467 | — |
| Novant Health Cancer Institute- Hematology | Charlotte | North Carolina | 28204 | — |
| Prisma Health Cancer Institute | Greenville | South Carolina | 29615 | — |
| Tennessee Oncology, PLLC | Nashville | Tennessee | 37203 | — |
| Henry-Joyce Cancer Center | Nashville | Tennessee | 37232 | — |
| University of Texas Southwestern Medical Center | Dallas | Texas | 75235 | — |
| The University of Texas, MD Anderson Cancer Center | Houston | Texas | 77030 | — |
| Intermountain LDS Hospital/Blood and Marrow Transplant/ Acute Leukemia Program | Salt Lake City | Utah | 84143 | — |
| Virginia Commonwealth University | Richmond | Virginia | 23298 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
Non-U.S. locations
This page focuses on the U.S. directory. The official record also lists 53 non-U.S. sites.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT05605899, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Apr 14, 2026 · Synced May 7, 2026
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Open the official record
The complete protocol, eligibility criteria, and contact information for NCT05605899 live on ClinicalTrials.gov.