A Study of Olezarsen (ISIS 678354) in Participants With Hypertriglyceridemia and Atherosclerotic Cardiovascular Disease, or With Severe Hypertriglyceridemia
Public ClinicalTrials.gov record NCT05610280. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
A Randomized, Double-blind, Placebo-Controlled, Phase 3 Study of Olezarsen (ISIS 678354) in Patients With Hypertriglyceridemia and Atherosclerotic Cardiovascular Disease (Established or at Increased Risk for), or With Severe Hypertriglyceridemia
Brief summary
Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.
The purpose of the study is to evaluate the effect of olezarsen on percent change in fasting triglyceride (TG) levels compared to placebo in participants with hypertriglyceridemia and atherosclerotic cardiovascular disease, or with severe hypertriglyceridemia.
Study identification
- NCT ID
- NCT05610280
- Recruitment status
- Completed
- Study type
- Interventional
- Phase
- Phase 3
- Enrollment
- 1,478 participants
Conditions and interventions
Eligibility (public fields only)
- Age range
- 18 Years and older
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Nov 21, 2022 (Actual)
- Primary completion
- Aug 8, 2024 (Actual)
- Completion
- Jun 9, 2025 (Actual)
- Last update posted
- Feb 10, 2026
2022 – 2025
United States locations
- U.S. sites
- 68
- U.S. states
- 22
- U.S. cities
- 57
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| Alabama Clinical Therapeutics, LLC Alabaster | Birmingham | Alabama | 35235 | — |
| Heart Center Research PC | Huntsville | Alabama | 35801 | — |
| Cardiovascular Research Foundation of Southern California | Beverly Hills | California | 90210 | — |
| Westside Medical Associates of Los Angeles | Beverly Hills | California | 90211 | — |
| Diabetes/Lipid Management & Research Center | Huntington Beach | California | 92648 | — |
| University of California, San Diego (UCSD) | La Jolla | California | 92037 | — |
| Clinical Trials Research | Lincoln | California | 95648 | — |
| Amicis Research | Northridge | California | 91324 | — |
| Valley Clinical Trials, Inc. | Northridge | California | 91325 | — |
| Northern California Research | Sacramento | California | 95821 | — |
| Amicis Research Center | Santa Clarita | California | 91344 | — |
| Metabolic Institute of America | Tarzana | California | 91356 | — |
| Lundquist Institute for Biomedical Innovation at Harbor UCLA Medical Center | Torrance | California | 90502 | — |
| Amicis Research Center | Valencia | California | 91355 | — |
| Excel Clinical Medical Trials | Boca Raton | Florida | 33434 | — |
| Finlay Medical Research - West Palm | Greenacres City | Florida | 33467 | — |
| Global Research Associates | Homestead | Florida | 33030 | — |
| 3Sync Research | Lake Worth | Florida | 33460 | — |
| Finlay Medical Research | Miami | Florida | 33126 | — |
| Advanced Medical Research Institute (AMRI) | Miami | Florida | 33174 | — |
| De La Cruz Research Center, LL | Miami | Florida | 33184 | — |
| Suncoast Clinical Research, Inc. - New Port Richey | New Port Richey | Florida | 34652 | — |
| Suncoast Clinical Research, Inc. - Palm Harbor | New Port Richey | Florida | 34652 | — |
| Proactive Clinical Research | Oakland Park | Florida | 33309 | — |
| Ocala Cardiovascular Research | Ocala | Florida | 34471 | — |
| Comprehensive Medical & Research Center | Plantation | Florida | 33317 | — |
| Progressive Medical Research | Port Orange | Florida | 32127 | — |
| St. Johns Center for Clinical Research | Saint Augustine | Florida | 32086 | — |
| JSV Clinical Research Study, Inc | Tampa | Florida | 33634 | — |
| Centricity Research | Columbus | Georgia | 31904 | — |
| Atlanta Heart Specialists | Tucker | Georgia | 30084 | — |
| Evanston Premier Healthcare Research LLC | Evanston | Illinois | 60201 | — |
| Clinical Investigation Specialists, Inc | Gurnee | Illinois | 60031 | — |
| Affinity Health | Park Ridge | Illinois | 60068 | — |
| Cardiovascular Research of Northwest Indiana, LLC | Munster | Indiana | 46321 | — |
| Reid Hospital and Health Care Services | Richmond | Indiana | 47374 | — |
| West Broadway Clinic | Council Bluffs | Iowa | 51501 | — |
| Mercy One Iowa Heart Center | West Des Moines | Iowa | 50266 | — |
| University of Kansas Medical Center (KUMC) | Kansas City | Kansas | 66160 | — |
| Norton Cardiovascular Associates | Louisville | Kentucky | 40205 | — |
| Louisville Metabolic and Atherosclerosis Research Center | Louisville | Kentucky | 40213 | — |
| Maryland Cardiovascular Specialists | Baltimore | Maryland | 21229 | — |
| Aa Mrc, Llc | Flint | Michigan | 48504 | — |
| Palm Research Center, Inc. | Las Vegas | Nevada | 49148 | — |
| Clinical Research of South Nevada | Las Vegas | Nevada | 89104 | — |
| Palm Research Center, Inc. | Las Vegas | Nevada | 89148 | — |
| Medical University of South Carolina (MUSC) | Charleston | North Carolina | 29425 | — |
| Moses H. Cone Memorial Hospital | Greensboro | North Carolina | 27401 | — |
| Aultman Hospital Cardiology Clinical Trials | Canton | Ohio | 44710 | — |
| McConnell Heart Health Center | Columbus | Ohio | 43214 | — |
| Summit Research Group, LLC | Stow | Ohio | 44224 | — |
| Central Oklahoma Early Detection Center | Edmond | Oklahoma | 73034 | — |
| Green and Seidner Family Practice Associates | Lansdale | Pennsylvania | 19446 | — |
| Main Street Physicians Care Waterway | Little River | South Carolina | 29566 | — |
| OnSite Clinical Solutions, LLC | Rock Hill | South Carolina | 29732 | — |
| Monument Health Clinical Research | Rapid City | South Dakota | 57701 | — |
| Health Concepts | Rapid City | South Dakota | 57702 | — |
| The Jackson Clinic | Jackson | Tennessee | 38301 | — |
| Affinity Health Corp. | Nashville | Tennessee | 37203 | — |
| Tennessee Center for Clinical Trials | Tullahoma | Tennessee | 37388 | — |
| Baylor College of Medicine | Houston | Texas | 77030 | — |
| Juno Research, LLC | Houston | Texas | 77040 | — |
| Texas Institute of Cardiology | McKinney | Texas | 75071 | — |
| Southern Endocrinology Associates | Mesquite | Texas | 75149 | — |
| FMC Science | Round Rock | Texas | 78681 | — |
| Carient Heart & Vascular | Manassas | Virginia | 20109 | — |
| Manassas Clinical Research Center | Manassas | Virginia | 20110 | — |
| Charleston Area Medical Center (CAMC) Clinical Trials Center | Charleston | West Virginia | 25304 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
Non-U.S. locations
This page focuses on the U.S. directory. The official record also lists 100 non-U.S. sites.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT05610280, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Feb 10, 2026 · Synced Oct 20, 2026
Related: full search, browse by condition, browse by drug or therapy, browse by sponsor, browse by U.S. city.
Open the official record
The complete public registry record, listed eligibility criteria, and available contact information for NCT05610280 live on ClinicalTrials.gov.