Selinexor in Maintenance Therapy After Systemic Therapy for Participants With p53 Wild-Type, Advanced or Recurrent Endometrial Carcinoma

ClinicalTrials.gov ID: NCT05611931

Public ClinicalTrials.gov record NCT05611931. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.

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ClinicalTrials.gov public records Last synced May 4, 2026, 10:19 AM EDT

Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.

Official title

A Phase 3, Randomized, Placebo-Controlled, Double-Blind, Multicenter Trial of Selinexor in Maintenance Therapy After Systemic Therapy for Patients With p53 Wild-Type, Advanced or Recurrent Endometrial Carcinoma

Study identification

NCT ID: NCT05611931
Recruitment status: Recruiting
Study type: Interventional
Phase: Phase 3
Lead sponsor: Karyopharm Therapeutics Inc; Industry
Enrollment: 276 participants

Conditions and interventions

Conditions

Endometrial Cancer

Interventions

Matching Placebo for selinexor Drug
Selinexor Drug

Drug

Eligibility (public fields only)

Age range: 18 Years and older
Sex: All
Healthy volunteers: Healthy volunteers not accepted

This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.

Study timeline

Start date: Apr 17, 2023
Primary completion: Jul 31, 2026
Completion: Dec 31, 2027
Last update posted: Apr 22, 2026

2023 – 2028

United States locations

U.S. sites: 84
U.S. states: 32
U.S. cities: 73

Facility	City	State	ZIP	Site status
The University of Alabama at Birmingham	Birmingham	Alabama	35205	Recruiting
Honor Health	Phoenix	Arizona	85016	Recruiting
University of Arkansas for Medical Sciences	Little Rock	Arkansas	72205	Recruiting
UC DAVIS	Davis	California	95616	Recruiting
City of Hope National Medical Center	Duarte	California	91010	Recruiting
Chao Family Comprehensive Cancer Center and Ambulatory Care	Irvine	California	92612	Withdrawn
City of Hope at Irvine Lennar	Irvine	California	92618	Recruiting
Cancer and Blood Specialty Clinic	Los Alamitos	California	90720	Recruiting
UCLA - Women's Health Clinical Research Unit	Los Angeles	California	90095	Recruiting
Long Beach Memorial Medical Center	Los Angeles	California	90806	Recruiting
UC Irvine	Orange	California	92868	Withdrawn
Stanford University	Palo Alto	California	94304	Recruiting
California Pacific Medical Center	San Francisco	California	94109	Recruiting
Highlands Ranch Hospital	Highlands Ranch	Colorado	80129	Withdrawn
University of Colorado Cancer Center	Highlands Ranch	Colorado	80129	Withdrawn
Broward Health Medical Center	Fort Lauderdale	Florida	33316	Recruiting
Mount Sinai Comprehensive Cancer Center	Miami Beach	Florida	33140	Recruiting
Advent Health	Orlando	Florida	32804	Recruiting
Grady Hospital	Atlanta	Georgia	30303	Recruiting
Emory University	Atlanta	Georgia	30322	Recruiting
Georgia Cancer Center at Augusta University	Augusta	Georgia	30912	Recruiting
Northeast Georgia Medical Center	Gainesville	Georgia	30501	Recruiting
Illinois Cancer Specialists	Arlington Heights	Illinois	60005	Recruiting
NorthShore University Health System	Evanston	Illinois	60201	Recruiting
Northwest Cancer Center	Dyer	Indiana	46311	Recruiting
Goshen Health	Goshen	Indiana	46526	Recruiting
St Vincent Hospital	Indianapolis	Indiana	46260	Recruiting
Memorial Hospital of South Bend	South Bend	Indiana	46601	Recruiting
University of Iowa	Iowa City	Iowa	52242	Recruiting
Our Lady of the Lake Hospital, Inc.	Baton Rouge	Louisiana	70808	Recruiting
LSU Health Sciences Center New Orleans	New Orleans	Louisiana	70119	Recruiting
Trials365, LLC	Shreveport	Louisiana	71133	Recruiting
Tufts Medical Center	Boston	Massachusetts	02111	Recruiting
Karmanos Cancer Institute	Detroit	Michigan	48201	Recruiting
USON - Minnesota Oncology Hematology	Minneapolis	Minnesota	55404	Recruiting
University of Minnesota	Minneapolis	Minnesota	55455	Recruiting
St. Dominic's Gynecologic Oncology	Jackson	Mississippi	39216	Recruiting
Midwest Ventures Group HCA MId America Division	Kansas City	Missouri	64132	Recruiting
Washington University School of Medicine	St Louis	Missouri	63108	Withdrawn
Intermountain Health St. Vincent Regional Hospital	Billings	Montana	59101	Recruiting
Women's Cancer Center of Nevada	Las Vegas	Nevada	89106	Recruiting
Center Of Hope	Reno	Nevada	89511	Recruiting
Hackensack Meridian Health Jersey Shore University Medical Center	Neptune City	New Jersey	07753	Recruiting
Women's Cancer Care Associates, LLC	Albany	New York	12208	Recruiting
NYU Langone Hospital-Long Island	Mineola	New York	11501	Recruiting
Northwell Health - Zuckerberg Cancer Center	New Hyde Park	New York	11042	Recruiting
Mount Sinai Chelsea	New York	New York	10011	Withdrawn
Perlmutter Cancer Center at NYU Langone Health	New York	New York	10016	Recruiting
Mount Sinai	New York	New York	10029	Withdrawn
Lenox Hill Hospital	New York	New York	10075	Recruiting
Northwell Health - Queens Cancer Center	Rego Park	New York	11374	Recruiting
University of Rochester	Rochester	New York	14642	Recruiting
Atrium Health Levine Cancer Institute	Charlotte	North Carolina	28209	Recruiting
Duke Cancer Center	Durham	North Carolina	27710	Recruiting
University of Cincinnati Medical Center	Cincinnati	Ohio	45219	Recruiting
MetroHealth	Cleveland	Ohio	44109	Recruiting
Zangmeister Cancer Center	Columbus	Ohio	43219	Recruiting
ProMedica Flower Hospital	Sylvania	Ohio	43560	Recruiting
University of Oklahoma Health Sciences Center	Oklahoma City	Oklahoma	73104	Recruiting
Oklahoma Cancer Specialists and Research Institute, LLC	Tulsa	Oklahoma	74146	Recruiting
Oncology Associates of Oregon	Eugene	Oregon	97401	Recruiting
Providence Portland Medical Center	Portland	Oregon	97213	Recruiting
Alliance Cancer Specialists	Langhorne	Pennsylvania	19047	Recruiting
Magee - Women's Hospital	Pittsburgh	Pennsylvania	15213	Recruiting
Allegheny Health Network - West Penn Hospital	Pittsburgh	Pennsylvania	15224	Recruiting
Avera	Sioux Falls	South Dakota	57105	Recruiting
Chattanooga's Program in Women's Oncology	Chattanooga	Tennessee	37403	Withdrawn
The West Clinic, PLLC dba West Cancer Center	Germantown	Tennessee	38138	Withdrawn
University of Tennessee Medical Center	Knoxville	Tennessee	37920	Recruiting
University of Tennessee Health Science Center	Memphis	Tennessee	38103	Recruiting
USON - Texas Oncology, Austin Central	Austin	Texas	78731	Recruiting
Parkland Health & Hospital System	Dallas	Texas	75235	Recruiting
Texas Oncology - Dallas	Dallas	Texas	75246	Recruiting
University of Texas Southwestern Medical Center	Dallas	Texas	75390	Recruiting
Texas Oncology - Fort Worth	Fort Worth	Texas	76104	Withdrawn
Houston Methodist	Houston	Texas	77030	Recruiting
Texas Oncology - San Antonio	San Antonio	Texas	78240	Recruiting
Texas Oncology - The Woodlands	The Woodlands	Texas	77380	Recruiting
Texas Oncology, PC, Tyler	Tyler	Texas	75702	Recruiting
University of Utah	Salt Lake City	Utah	84112	Recruiting
University of Virginia	Charlottesville	Virginia	22908	Recruiting
Swedish Cancer Institute	Seattle	Washington	98104	Recruiting
University of Wisconsin Hospital and Clinics	Madison	Wisconsin	53792	Recruiting
Medical College of Wisconsin/ Freodtert Hospital	Milwaukee	Wisconsin	53226	Withdrawn

Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.

Non-U.S. locations

This page focuses on the U.S. directory. The official record also lists 133 non-U.S. sites.

About this trial record page

What this page shows: Public field values for ClinicalTrials.gov record NCT05611931, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
What this page does not do: No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
Where the data comes from: Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
Last refresh: Last update posted Apr 22, 2026 · Synced May 4, 2026

Open the official record

The complete protocol, eligibility criteria, and contact information for NCT05611931 live on ClinicalTrials.gov.

View official ClinicalTrials.gov record →