Frespaciguat (MK-5475) INSIGNIA-PH-COPD: A Study of the Efficacy and Safety of Frespaciguat (an Inhaled sGC Stimulator) in Adults With PH-COPD
Public ClinicalTrials.gov record NCT05612035. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
A Phase 2a Randomized, Placebo-Controlled Clinical Study to Evaluate the Efficacy and Safety of MK-5475 in Adults With Pulmonary Hypertension Associated With Chronic Obstructive Pulmonary Disease
Brief summary
Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.
Researchers are looking for ways to treat pulmonary hypertension (PH) caused by chronic obstructive pulmonary disease (COPD). The goal of the study is to learn if people who take frespaciguat can walk farther in 6 minutes at Week 24 compared to people who take placebo.
Study identification
- NCT ID
- NCT05612035
- Recruitment status
- Active, not recruiting
- Study type
- Interventional
- Phase
- Phase 2
- Enrollment
- 129 participants
Conditions and interventions
Eligibility (public fields only)
- Age range
- 40 Years to 85 Years
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Mar 16, 2023 (Actual)
- Primary completion
- Apr 9, 2026 (Actual)
- Completion
- Oct 8, 2029 (Estimated)
- Last update posted
- May 1, 2026
2023 – 2029
United States locations
- U.S. sites
- 18
- U.S. states
- 16
- U.S. cities
- 18
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| UCSF Helen Diller Medical Center at Parnassus Heights ( Site 0110) | San Francisco | California | 94143 | — |
| University of Colorado Anschutz Medical Campus-University of Colorado Hospital Cardiac and Vascular ( Site 0101) | Aurora | Colorado | 80045 | — |
| Clinovation Intl. Corp. ( Site 0108) | Sebring | Florida | 33870 | — |
| Alexian Brothers Medical Center-Pulmonary ( Site 0109) | Elk Grove Village | Illinois | 60007 | — |
| University of Iowa ( Site 0103) | Iowa City | Iowa | 52242 | — |
| University of Kansas Medical Center-IM-Pulmonary and Critical Care Medicine ( Site 0102) | Kansas City | Kansas | 66160 | — |
| Lexington VA Medical Center - Cooper Division ( Site 0137) | Lexington | Kentucky | 40502 | — |
| Corewell Health ( Site 0133) | Grand Rapids | Michigan | 49546 | — |
| Mayo Clinic in Rochester, Minnesota ( Site 0131) | Rochester | Minnesota | 55905 | — |
| Creighton University Clinical Research Office ( Site 0123) | Omaha | Nebraska | 68124 | — |
| University of New Mexico Hospital ( Site 0146) | Albuquerque | New Mexico | 87106 | — |
| UNC Health - Eastowne Medical Office-Clinical Trials Unit ( Site 0147) | Chapel Hill | North Carolina | 27514 | — |
| Temple University Hospital ( Site 0104) | Philadelphia | Pennsylvania | 19140 | — |
| UPMC Montefiore University Hospital-Department of Medicine ( Site 0149) | Pittsburgh | Pennsylvania | 15213 | — |
| UT Southwestern Medical Center ( Site 0114) | Dallas | Texas | 75390 | — |
| The University of Texas Health Science Center at Houston ( Site 0105) | Houston | Texas | 77030 | — |
| Intermountain Medical Center-Division of Pulmonary & Critical Care Medicine ( Site 0140) | Murray | Utah | 84107 | — |
| University of Virginia Health System-Division of Pulmonary and Critical Care Medicine ( Site 0111) | Charlottesville | Virginia | 22908 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
Non-U.S. locations
This page focuses on the U.S. directory. The official record also lists 67 non-U.S. sites.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT05612035, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted May 1, 2026 · Synced Oct 29, 2026
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Open the official record
The complete public registry record, listed eligibility criteria, and available contact information for NCT05612035 live on ClinicalTrials.gov.