Mindfulness-Based fMRI Neurofeedback for Depression

ClinicalTrials.gov ID: NCT05617495

Public ClinicalTrials.gov record NCT05617495. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.

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Official title

Targeting Adolescent Depression Symptoms Using Network-based Real-time fMRI Neurofeedback and Mindfulness Meditation (NIMH); Mindfulness-Based Real-Time fMRI Neurofeedback for Depression (IRB)

Brief summary

Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.

In the United States, adolescents experience alarmingly high rates of major depression, and gold-standard treatments are only effective for approximately half of patients. Rumination may be a promising treatment target, as it is well-characterized at the neural level and contributes to depression onset, maintenance, and recurrence as well as predicts treatment non-response. Accordingly, the proposed research will investigate whether an innovative mindfulness-based real-time functional magnetic resonance imaging (fMRI) neurofeedback intervention successfully elicits change in the brain circuit underlying rumination to improve clinical outcomes among depressed adolescents.

Study identification

NCT ID: NCT05617495
Recruitment status: Recruiting
Study type: Interventional
Phase: Not applicable
Lead sponsor: Columbia University; Other
Enrollment: 90 participants

Conditions and interventions

Conditions

Interventions

Mindfulness + fMRI Neurofeedback Other

Other

Eligibility (public fields only)

Age range: 13 Years to 18 Years
Sex: All
Healthy volunteers: Healthy volunteers not accepted

This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.

Study timeline

Start date: Apr 9, 2024
Primary completion: Jan 30, 2027
Completion: Jun 29, 2027
Last update posted: Apr 28, 2026

2024 – 2027

United States locations

U.S. sites: 2
U.S. states: 2
U.S. cities: 2

Facility	City	State	ZIP	Site status
Northeastern University	Boston	Massachusetts	02115	Recruiting
Columbia University Irving Medical Center	New York	New York	10032	Recruiting

Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.

About this trial record page

What this page shows: Public field values for ClinicalTrials.gov record NCT05617495, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
What this page does not do: No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
Where the data comes from: Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
Last refresh: Last update posted Apr 28, 2026 · Synced Sep 6, 2026

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The complete protocol, eligibility criteria, and contact information for NCT05617495 live on ClinicalTrials.gov.

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