Efficacy and Safety of Tozorakimab in Patients Hospitalised for Viral Lung Infection Requiring Supplemental Oxygen

ClinicalTrials.gov ID: NCT05624450

Public ClinicalTrials.gov record NCT05624450. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.

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ClinicalTrials.gov public records Last synced Sep 8, 2026, 2:35 PM EDT

Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.

Official title

A Phase III, Multicentre, Randomised, Double-blind, Parallel-group, Placebo-controlled Study to Evaluate the Efficacy and Safety of Tozorakimab (MEDI3506) in Patients Hospitalised for Viral Lung Infection Requiring Supplemental Oxygen

Brief summary

Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.

The purpose of this study is to evaluate the effect of tozorakimab, as an add-on to SoC in patients with viral lung infection requiring supplemental oxygen, on the prevention of death or progression to IMV/ECMO.

Study identification

NCT ID: NCT05624450
Recruitment status: Recruiting
Study type: Interventional
Phase: Phase 3
Lead sponsor: AstraZeneca; Industry
Enrollment: 3,527 participants

Conditions and interventions

Conditions

Viral Lung Infection and Acute Respiratory Failure

Interventions

Tozorakimab Drug
Placebo Drug

Drug

Eligibility (public fields only)

Age range: 18 Years and older
Sex: All
Healthy volunteers: Healthy volunteers not accepted

This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.

Study timeline

Start date: Dec 12, 2022
Primary completion: Nov 3, 2027
Completion: Nov 3, 2027
Last update posted: Aug 27, 2026

2022 – 2027

United States locations

U.S. sites: 74
U.S. states: 32
U.S. cities: 69

Facility	City	State	ZIP	Site status
Research Site	Birmingham	Alabama	35294	Not yet recruiting
Research Site	Mobile	Alabama	36608	Recruiting
Research Site	Phoenix	Arizona	85008	Completed
Research Site	Phoenix	Arizona	85013	Withdrawn
Research Site	Tucson	Arizona	85719	Recruiting
Research Site	Chula Vista	California	91911	Withdrawn
Research Site	Fresno	California	93701	Recruiting
Research Site	La Mesa	California	91942	Withdrawn
Research Site	Los Angeles	California	90027	Withdrawn
Research Site	Newport Beach	California	92663	Recruiting
Research Site	Torrance	California	90505	Recruiting
Research Site	Colorado Springs	Colorado	80909	Recruiting
Research Site	Denver	Colorado	80206	Withdrawn
Research Site	Washington D.C.	District of Columbia	20037	Recruiting
Research Site	Bradenton	Florida	34209	Withdrawn
Research Site	Gainesville	Florida	32611	Recruiting
Research Site	Jacksonville	Florida	32224	Recruiting
Research Site	Lakeland	Florida	33805	Recruiting
Research Site	Miami	Florida	33144	Withdrawn
Research Site	South Pasadena	Florida	33707	Completed
Research Site	St. Petersburg	Florida	33709	Withdrawn
Research Site	Tampa	Florida	33617	Recruiting
Research Site	Atlanta	Georgia	30322	Withdrawn
Research Site	Boise	Idaho	83702	Recruiting
Research Site	Chicago	Illinois	60612	Completed
Research Site	Elmhurst	Illinois	60126	Withdrawn
Research Site	Evanston	Illinois	60201	Recruiting
Research Site	Fort Wayne	Indiana	46804	Withdrawn
Research Site	Iowa City	Iowa	52242	Withdrawn
Research Site	Kansas City	Kansas	66160	Withdrawn
Research Site	Louisville	Kentucky	40202	Recruiting
Research Site	Baton Rouge	Louisiana	70808	Recruiting
Research Site	New Orleans	Louisiana	70121	Withdrawn
Research Site	Shreveport	Louisiana	71103	Completed
Research Site	Annapolis	Maryland	21401	Recruiting
Research Site	Silver Spring	Maryland	20910	Completed
Research Site	Springfield	Massachusetts	01199	Completed
Research Site	Worcester	Massachusetts	01655	Completed
Research Site	Detroit	Michigan	48202	Withdrawn
Research Site	Royal Oak	Michigan	48073	Recruiting
Research Site	Saint Paul	Minnesota	55101	Recruiting
Research Site	Columbia	Missouri	65212	Completed
Research Site	Kansas City	Missouri	64108	Recruiting
Research Site	St Louis	Missouri	63110	Recruiting
Research Site	Brooklyn	New York	11203	Withdrawn
Research Site	Buffalo	New York	14203	Not yet recruiting
Research Site	New York	New York	10016	Withdrawn
Research Site	New York	New York	10039	Recruiting
Research Site	Potsdam	New York	13676	Completed
Research Site	Chapel Hill	North Carolina	27514	Withdrawn
Research Site	Durham	North Carolina	27705	Not yet recruiting
Research Site	Greenville	North Carolina	27834	Withdrawn
Research Site	Winston-Salem	North Carolina	27157	Recruiting
Research Site	Cleveland	Ohio	44195	Withdrawn
Research Site	Columbus	Ohio	43210	Recruiting
Research Site	Toledo	Ohio	43614	Not yet recruiting
Research Site	Oklahoma City	Oklahoma	73104	Recruiting
Research Site	Corvallis	Oregon	97330	Completed
Research Site	Portland	Oregon	97239	Withdrawn
Research Site	Philadelphia	Pennsylvania	19107	Withdrawn
Research Site	Providence	Rhode Island	02903	Completed
Research Site	Greenville	South Carolina	29605	Recruiting
Research Site	Sioux Falls	South Dakota	57105	Withdrawn
Research Site	Amarillo	Texas	79106	Not yet recruiting
Research Site	Dallas	Texas	75203	Completed
Research Site	Dallas	Texas	75204	Recruiting
Research Site	El Paso	Texas	79905	Recruiting
Research Site	Houston	Texas	77030	Completed
Research Site	Houston	Texas	77090	Withdrawn
Research Site	Salt Lake City	Utah	84107	Recruiting
Research Site	Salt Lake City	Utah	84132	Not yet recruiting
Research Site	Charlottesville	Virginia	22908	Recruiting
Research Site	Green Bay	Wisconsin	54311	Completed
Research Site	Milwaukee	Wisconsin	53295	Withdrawn

Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.

Non-U.S. locations

This page focuses on the U.S. directory. The official record also lists 389 non-U.S. sites.

About this trial record page

What this page shows: Public field values for ClinicalTrials.gov record NCT05624450, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
What this page does not do: No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
Where the data comes from: Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
Last refresh: Last update posted Aug 27, 2026 · Synced Sep 8, 2026

Open the official record

The complete protocol, eligibility criteria, and contact information for NCT05624450 live on ClinicalTrials.gov.

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