Comparison of Breast Cancer Screening With CESM to DBT in Women With Dense Breasts
Public ClinicalTrials.gov record NCT05625659. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
Comparison of Breast Cancer Screening With Dual-Energy Contrast-Enhanced Spectral Mammography to Digital Breast Tomosynthesis in Women With Dense Breasts (Contrast Mammography Imaging Screening Trial
Brief summary
Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.
The over-arching goal of the Contrast-Enhanced Spectral Mammography Imaging Screening Trial (CMIST) is to determine if dual-energy contrast-enhanced spectral mammography (CESM) can detect more cancers with fewer false positives than digital breast tomosynthesis (DBT) in women with dense breasts. Aim 1: To evaluate the performance of CESM compared to DBT at baseline for breast-cancer screening in women with dense breasts. Aim 2: To evaluate the performance of CESM compared to DBT at the 1-year follow up for breast-cancer screening in women with dense breasts.
Study identification
- NCT ID
- NCT05625659
- Recruitment status
- Recruiting
- Study type
- Interventional
- Phase
- Not applicable
- Enrollment
- 2,032 participants
Conditions and interventions
Conditions
Interventions
- Dual-Energy Contrast-Enhanced Spectral Mammography (CESM) Diagnostic Test
Diagnostic Test
Eligibility (public fields only)
- Age range
- 45 Years to 74 Years
- Sex
- Female
- Healthy volunteers
- Accepts healthy volunteers
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Mar 23, 2023
- Primary completion
- Jul 30, 2027
- Completion
- Jul 30, 2027
- Last update posted
- Jul 30, 2026
2023 – 2027
United States locations
- U.S. sites
- 12
- U.S. states
- 10
- U.S. cities
- 12
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| University of Alabama, Birmingham | Birmingham | Alabama | 35233 | Recruiting |
| Boca Raton Regional Hospital - Christine E. Lynn Women's Health and Wellness Institute | Boca Raton | Florida | 33486 | Recruiting |
| Lake Medical Imaging | The Villages | Florida | 32159 | Active, not recruiting |
| Massachusetts General Hospital | Boston | Massachusetts | 02114 | Recruiting |
| Boston Breast Diagnostic Center | Wellesley Hills | Massachusetts | 02481 | Recruiting |
| Henry Ford Health | Detroit | Michigan | 48202 | Recruiting |
| Thomas Jefferson University | Sewell | New Jersey | 08080 | Recruiting |
| Memorial Sloan Kettering Cancer Center | New York | New York | 10065 | Recruiting |
| Carolina Breast Imaging Specialists | Greenville | North Carolina | 27834 | Recruiting |
| Thomas Jefferson University Hospital | Philadelphia | Pennsylvania | 19107 | Recruiting |
| The University of Texas MD Anderson Cancer Center | Houston | Texas | 77030 | Recruiting |
| University of Virginia | Charlottesville | Virginia | 22911 | Recruiting |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
Non-U.S. locations
This page focuses on the U.S. directory. The official record also lists 1 non-U.S. site.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT05625659, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Jul 30, 2026 · Synced Sep 6, 2026
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Open the official record
The complete protocol, eligibility criteria, and contact information for NCT05625659 live on ClinicalTrials.gov.