A Study to Optimize Subretinal Surgical Delivery and to Evaluate Safety and Activity of Opregen in Participants With Geographic Atrophy Secondary to Age-Related Macular Degeneration (GAlette); Adaptive Optics (AO) Retinal Imaging Substudy in Association With Study GR44251

ClinicalTrials.gov ID: NCT05626114

Public ClinicalTrials.gov record NCT05626114. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.

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ClinicalTrials.gov public records Last synced Apr 22, 2026, 1:21 PM EDT

Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.

Official title

A Phase IIa, Multicenter, Open-label, Single-Arm Study to Optimize Subretinal Surgical Delivery and to Evaluate Safety and Activity of Opregen in Patients With Geographic Atrophy Secondary to Age-Related Macular Degeneration

Study identification

NCT ID: NCT05626114
Recruitment status: Recruiting
Study type: Interventional
Phase: Phase 2
Lead sponsor: Genentech, Inc.; Industry
Enrollment: 60 participants

Conditions and interventions

Conditions

Geographic Atrophy

Interventions

OpRegen Biological

Biological

Eligibility (public fields only)

Age range: 50 Years and older
Sex: All
Healthy volunteers: Not listed

This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.

Study timeline

Start date: Mar 22, 2023
Primary completion: Feb 28, 2031
Completion: Feb 28, 2031
Last update posted: Apr 20, 2026

2023 – 2031

United States locations

U.S. sites: 15
U.S. states: 12
U.S. cities: 15

Facility	City	State	ZIP	Site status
Retina-Vitreous Associates Medical Group	Beverly Hills	California	90211	Recruiting
Retinal Consultants Medical Group	Sacramento	California	95825	Recruiting
West Coast Retina	San Francisco	California	94109-5520	Recruiting
Retina Vitreous Associates of Florida	St. Petersburg	Florida	33711	Recruiting
The Retina Care Center	Baltimore	Maryland	21209-2219	Recruiting
The Retina Institute	St Louis	Missouri	63128-1729	Recruiting
Sierra Eye Associates	Reno	Nevada	89502-1605	Recruiting
Duke Eye Center	Durham	North Carolina	27705-4699	Recruiting
Cincinnati Eye Institute	Blue Ash	Ohio	45242-5537	Recruiting
Mid Atlantic Retina	Philadelphia	Pennsylvania	19107-5109	Recruiting
Tennessee Retina PC	Nashville	Tennessee	37203-1513	Recruiting
Austin Clinical Research, LLC	Austin	Texas	78750-2298	Recruiting
Retina Consultants of Texas	Bellaire	Texas	77401	Recruiting
Piedmont Eye Center	Lynchburg	Virginia	24502-4271	Recruiting
Spokane Eye Clinical Research;Spokane Eye Surgery Center	Spokane	Washington	99204	Recruiting

Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.

Non-U.S. locations

This page focuses on the U.S. directory. The official record also lists 2 non-U.S. sites.

About this trial record page

What this page shows: Public field values for ClinicalTrials.gov record NCT05626114, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
What this page does not do: No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
Where the data comes from: Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
Last refresh: Last update posted Apr 20, 2026 · Synced Apr 22, 2026

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The complete protocol, eligibility criteria, and contact information for NCT05626114 live on ClinicalTrials.gov.

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