A Study to Optimize Subretinal Surgical Delivery and to Evaluate Safety and Activity of Opregen in Participants With Geographic Atrophy Secondary to Age-Related Macular Degeneration (GAlette); Adaptive Optics (AO) Retinal Imaging Substudy in Association With Study GR44251
Public ClinicalTrials.gov record NCT05626114. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
A Phase IIa, Multicenter, Open-label, Single-Arm Study to Optimize Subretinal Surgical Delivery and to Evaluate Safety and Activity of Opregen in Patients With Geographic Atrophy Secondary to Age-Related Macular Degeneration
Brief summary
Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.
This study will evaluate the success and safety of subretinal surgical delivery as well as the preliminary activity of OpRegen in participants with geographic atrophy (GA) secondary to age-related macular degeneration (AMD). All endpoints are assessed for the study eye unless otherwise indicated. The substudy will evaluate the operational feasibility and scientific interpretability of incorporating AO retinal imaging using the EarlySight Cellularis® Discovery device. Participants who have fulfilled the eligibility requirements for the parent study and meet the substudy's eligibility criteria will have the option to participate in the substudy. The EarlySight Cellularis® Discovery device will be used only as an assessment tool and data obtained from this device will not be used to guide clinical care or influence clinical outcomes for participants.
Study identification
- NCT ID
- NCT05626114
- Recruitment status
- Recruiting
- Study type
- Interventional
- Phase
- Phase 2
- Enrollment
- 60 participants
Conditions and interventions
Conditions
Eligibility (public fields only)
- Age range
- 50 Years and older
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Mar 22, 2023
- Primary completion
- Feb 28, 2031
- Completion
- Feb 28, 2031
- Last update posted
- Aug 13, 2026
2023 – 2031
United States locations
- U.S. sites
- 15
- U.S. states
- 12
- U.S. cities
- 15
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| Retina-Vitreous Associates Medical Group | Beverly Hills | California | 90211 | Recruiting |
| Retinal Consultants Medical Group | Sacramento | California | 95825 | Recruiting |
| West Coast Retina | San Francisco | California | 94109-5520 | Recruiting |
| Retina Vitreous Associates of Florida | St. Petersburg | Florida | 33711-1141 | Recruiting |
| The Retina Care Center | Baltimore | Maryland | 21209-2219 | Recruiting |
| The Retina Institute | St Louis | Missouri | 63128-1729 | Recruiting |
| Sierra Eye Associates | Reno | Nevada | 89502-1605 | Recruiting |
| Duke Eye Center | Durham | North Carolina | 27705-4699 | Recruiting |
| Cincinnati Eye Institute | Blue Ash | Ohio | 45242-5537 | Recruiting |
| Mid Atlantic Retina | Philadelphia | Pennsylvania | 19107-5109 | Recruiting |
| Tennessee Retina PC | Nashville | Tennessee | 37203-1513 | Recruiting |
| Austin Clinical Research, LLC | Austin | Texas | 78750-2298 | Recruiting |
| Retina Consultants of Texas | Bellaire | Texas | 77401 | Recruiting |
| Piedmont Eye Center | Lynchburg | Virginia | 24502-4271 | Recruiting |
| Spokane Eye Clinical Research;Spokane Eye Surgery Center | Spokane | Washington | 99204 | Recruiting |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
Non-U.S. locations
This page focuses on the U.S. directory. The official record also lists 2 non-U.S. sites.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT05626114, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Aug 13, 2026 · Synced Sep 3, 2026
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Open the official record
The complete protocol, eligibility criteria, and contact information for NCT05626114 live on ClinicalTrials.gov.