A Pivotal Study of Sensory Stimulation in Alzheimer's Disease (HOPE Study)
Public ClinicalTrials.gov record NCT05637801. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
A Randomized, Double-blind, Sham-controlled Pivotal Study of Sensory Stimulation in Subjects With Alzheimer's Disease (HOPE Study)
Brief summary
Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.
This is a randomized, double-blind, sham-controlled pivotal study of sensory stimulation in subjects with mild to moderate AD. Up to approximately 670 subjects will be treated with either Active or Sham investigational device, Spectris™ AD, for 60 minutes daily for approximately 12 months. Efficacy will be measured using the Integrated Alzheimer's Disease Mini-Mental State Exam (MMSE) Activities of Daily Living (ADCS-ADL) Rating Scale (iADMARS).
Study identification
- NCT ID
- NCT05637801
- Recruitment status
- Completed
- Study type
- Interventional
- Phase
- Not applicable
- Enrollment
- 673 participants
Conditions and interventions
Conditions
- Alzheimer Disease
- Alzheimer Disease 1
- Alzheimer Disease 2
- Alzheimer Disease 3
- Alzheimer Disease, Early Onset
- Alzheimer Disease, Late Onset
- Alzheimer Disease 9
- Alzheimer Disease 4
- Alzheimer Disease 7
- Alzheimer Disease 17
- Alzheimer's Dementia Late Onset
- Alzheimer Disease 5
- Alzheimer Disease 6
- Alzheimer Disease 8
- Alzheimer Disease 10
- Alzheimer Disease 11
- Alzheimer Disease 12
- Alzheimer Disease 13
- Alzheimer Disease 14
- Alzheimer Disease 15
- Alzheimer Disease 16
- Alzheimer Disease 18
- Alzheimer Disease 19
- Dementia
- Dementia Alzheimers
- Dementia, Mild
- Dementia of Alzheimer Type
- Dementia Moderate
- Dementia Senile
- Mild Cognitive Impairment
- Mild Dementia
- MCI
- Cognitive Impairment
- Cognitive Decline
- Cognitive Impairment, Mild
Eligibility (public fields only)
- Age range
- 50 Years to 90 Years
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Dec 13, 2022 (Actual)
- Primary completion
- Jun 22, 2026 (Actual)
- Completion
- Aug 17, 2026 (Actual)
- Last update posted
- Sep 9, 2026
2022 – 2026
United States locations
- U.S. sites
- 68
- U.S. states
- 25
- U.S. cities
- 65
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| CCT Research - Gilbert Neurology Partners | Gilbert | Arizona | 85297 | — |
| Barrow Neurological Institute | Phoenix | Arizona | 85013 | — |
| CCT Research - Foothills Research Center | Phoenix | Arizona | 85044 | — |
| Banner Sun Health Research Institute | Sun City | Arizona | 85351 | — |
| Advanced Research Center, Inc | Anaheim | California | 92805 | — |
| ATP Clinical Research, Inc. | Costa Mesa | California | 92626 | — |
| Neurology Center of North Orange County | Fullerton | California | 92835 | — |
| Syrentis Clinical Research | Santa Ana | California | 92705 | — |
| Office of Elizabeth Zarate-Rowell, MD | Seal Beach | California | 90740 | — |
| Mile High Research Center | Denver | Colorado | 80218 | — |
| JEM Research Institute | Atlantis | Florida | 33462 | — |
| Visionary Investigators Network- Aventura | Aventura | Florida | 33180 | — |
| South Lake Pain Institute | Clermont | Florida | 34711 | — |
| Arrow Clinical Trials | Daytona Beach | Florida | 32117 | — |
| Brain Matters Research | Delray Beach | Florida | 33445 | — |
| Neuropsychiatric Research Center of Southwest Florida | Fort Myers | Florida | 33912 | — |
| Alphab Global Research | Jupiter | Florida | 33458 | — |
| Charter Research - Lady Lake | Lady Lake | Florida | 32792 | — |
| Multi-Specialty Research Associates, Inc. | Lake City | Florida | 23055 | — |
| Premier Clinical Research Institute Inc. | Miami | Florida | 30033 | — |
| Visionary Investigators Network- Miami | Miami | Florida | 33133 | — |
| Aqualane Clinical Research | Naples | Florida | 34105 | — |
| Coastal Family Medicine - Orange Park | Orange Park | Florida | 32073 | — |
| K2 Medical Research - Orlando | Orlando | Florida | 32806 | — |
| Emerald Coast Neurology | Pensacola | Florida | 32504 | — |
| Quantum Laboratories | Pompano Beach | Florida | 33064 | — |
| Progressive Medical Research | Port Orange | Florida | 32127 | — |
| Intercoastal Medical Group - Sarasota | Sarasota | Florida | 34239 | — |
| Suncoast Neuroscience Associates | St. Petersburg | Florida | 33713 | — |
| Brain Matters Research | Stuart | Florida | 34997 | — |
| Axiom Clinical Research of Florida | Tampa | Florida | 33609 | — |
| Conquest Research | Winter Park | Florida | 32789 | — |
| Charter Research - Winter Park | Winter Park | Florida | 32792 | — |
| Emory Alzheimer's Disease Research Center | Atlanta | Georgia | 30329 | — |
| NeuroStudies | Decatur | Georgia | 30033 | — |
| Great Lakes Clinical Trials- Flourish Research- Chicago | Chicago | Illinois | 60640 | — |
| Great Lakes Clinical Trials- Flourish Research- Gurnee | Gurnee | Illinois | 60031 | — |
| Josephson Wallack Munshower Neurology, PC | Indianapolis | Indiana | 46256 | — |
| Northern Light Acadia Hospital | Bangor | Maine | 04402 | — |
| Boston Clinical Trials, Inc. | Boston | Massachusetts | 02131 | — |
| Boston Center for Memory | Newton | Massachusetts | 02459 | — |
| Office of Donald S. Marks, M.D., P.C. | Plymouth | Massachusetts | 02360 | — |
| Sisu BHR, LLC | Springfield | Massachusetts | 01103 | — |
| QUEST Research Institute | Farmington | Michigan | 48334 | — |
| Hattiesburg Clinic | Hattiesburg | Mississippi | 39401 | — |
| Clinical Research Professionals | Chesterfield | Missouri | 63005 | — |
| CCT Research - Papillion Research Center | Papillion | Nebraska | 68046 | — |
| Las Vegas Medical Research | Las Vegas | Nevada | 89113 | — |
| The Cognitive and Research Center of New Jersey | Springfield | New Jersey | 07081 | — |
| Neurological Associates of Albany | Albany | New York | 12208 | — |
| Integrative Clinical Trials, LLC | Brooklyn | New York | 11229 | — |
| Velocity Clinical Research - Syracuse | East Syracuse | New York | 13057 | — |
| Mid Hudson Medical Research | New Windsor | New York | 12553 | — |
| Alzheimer's Memory Center - AMC Research | Matthews | North Carolina | 28105 | — |
| Insight Clinical Trials, LLC | Beachwood | Ohio | 44122 | — |
| Neuro-Behavioral Clinical Research | Canton | Ohio | 44720 | — |
| The Ohio State University Wexner Medical Center | Columbus | Ohio | 43210 | — |
| Center for Cognitive Health - Portland | Portland | Oregon | 97225 | — |
| The Clinical Trial Center | Jenkintown | Pennsylvania | 19046 | — |
| Prisma Health Neurology | Columbia | South Carolina | 29203 | — |
| Coastal Neurology | Port Royal | South Carolina | 29935 | — |
| University of Tennessee Medical Center | Knoxville | Tennessee | 37920 | — |
| North Texas Clinical Trials | Fort Worth | Texas | 76104 | — |
| UT Health San Antonio, Glenn Biggs Institute for Alzheimer's and Neurodegenerative Diseases | San Antonio | Texas | 78229 | — |
| TRS Health | Stafford | Texas | 77477 | — |
| Mercury Clinical Research | Sugarland | Texas | 77478 | — |
| Wasatch Clinical Research | Salt Lake City | Utah | 84107 | — |
| ReCogniton Health | Fairfax | Virginia | 22031 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT05637801, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Sep 9, 2026 · Synced Oct 20, 2026
Related: full search, browse by condition, browse by drug or therapy, browse by sponsor, browse by U.S. city.
Open the official record
The complete public registry record, listed eligibility criteria, and available contact information for NCT05637801 live on ClinicalTrials.gov.