A Multicenter Trial Assessing the Impact of Lipoprotein(a) Lowering With Pelacarsen (TQJ230) on the Progression of Calcific Aortic Valve Stenosis
Public ClinicalTrials.gov record NCT05646381. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
A Randomized Double-blind, Placebo-controlled, Multicenter Trial Assessing the Impact of Lipoprotein(a) Lowering With Pelacarsen (TQJ230) on the Progression of Calcific Aortic Valve Stenosis [Lp(a)FRONTIERS CAVS]
Study identification
- NCT ID
- NCT05646381
- Recruitment status
- Recruiting
- Study type
- Interventional
- Phase
- Phase 2
- Lead sponsor
- Novartis Pharmaceuticals
- Industry
- Enrollment
- 502 participants
Conditions and interventions
Conditions
Interventions
- Matching placebo Drug
- Pelacarsen (TQJ230) 80mg Drug
Drug
Eligibility (public fields only)
- Age range
- 50 Years to 80 Years
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Mar 6, 2024
- Primary completion
- Mar 11, 2030
- Completion
- Mar 11, 2030
- Last update posted
- Apr 14, 2026
2024 – 2030
United States locations
- U.S. sites
- 34
- U.S. states
- 14
- U.S. cities
- 29
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| Heart Center Research Llc | Huntsville | Alabama | 35801 | Recruiting |
| Cardiovascular Res Found | Beverly Hills | California | 90210 | Recruiting |
| National Heart Institute | Beverly Hills | California | 90211 | Recruiting |
| Flourish Clinical Resrch Covin | Covina | California | 91723 | Recruiting |
| Valley Clinical Trials | Northridge | California | 91325 | Recruiting |
| Stanford University Medical Center | Palo Alto | California | 94304 | Recruiting |
| University Of California San Diego | San Diego | California | 92103-8415 | Recruiting |
| UC San Francisco Medical Center | San Francisco | California | 94143 | Recruiting |
| Excel Medical Clinical Trials LLC | Boca Raton | Florida | 33434 | Withdrawn |
| Nova Clinical Research LLC | Bradenton | Florida | 34209 | Recruiting |
| Flourish Res Acq LLC North Miami | Miami | Florida | 33138 | Recruiting |
| Inpatient Research Clinical LLC | Miami Lakes | Florida | 33014 | Recruiting |
| Advanced Research for Health Improvement LLC | Naples | Florida | 34102 | Active, not recruiting |
| Midwest Heart and Vascular Spec | Overland Park | Kansas | 66211 | Recruiting |
| Tufts Medical Center | Boston | Massachusetts | 02111 | Recruiting |
| Massachusetts General Hospital | Boston | Massachusetts | 02114 | Recruiting |
| Brigham and Womens Hosp Harvard Med School | Boston | Massachusetts | 02115 | Recruiting |
| Henry Ford Hospital | Detroit | Michigan | 48202 | Recruiting |
| AA Medical Research Center | Flint | Michigan | 48504 | Recruiting |
| William Beaumont Hospital | Royal Oak | Michigan | 48073-4192 | Recruiting |
| Minneapolis Heart Institute | Minneapolis | Minnesota | 55407 | Withdrawn |
| University Of Minnesota | Minneapolis | Minnesota | 55455 | Recruiting |
| Overlook Medical Center | Summit | New Jersey | 07901 | Recruiting |
| Capital Cardiology Associates | Albany | New York | 12211 | Recruiting |
| New York Presbyterian Hospital | New York | New York | 10021 | Active, not recruiting |
| Icahn School of Med at Mt Sinai | New York | New York | 10029 | Recruiting |
| Strong Memorial Hospital | Rochester | New York | 14642 | Recruiting |
| Wake Forest University Baptist Medical Center | Winston-Salem | North Carolina | 27157 | Recruiting |
| Lindner Ctr At The Christ Hosp | Cincinnati | Ohio | 45219 | Recruiting |
| Ohio State University | Columbus | Ohio | 43210 | Withdrawn |
| Perelman School of Medicine | Philadelphia | Pennsylvania | 19104 | Recruiting |
| Orion Medical | Houston | Texas | 77034 | Recruiting |
| Virginia Heart | Falls Church | Virginia | 22042 | Recruiting |
| Carient Heart and Vascular | Manassas | Virginia | 20109 | Recruiting |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
Non-U.S. locations
This page focuses on the U.S. directory. The official record also lists 102 non-U.S. sites.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT05646381, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Apr 14, 2026 · Synced May 21, 2026
Related: full search, browse by condition, browse by drug or therapy, browse by sponsor, browse by U.S. city.
Open the official record
The complete protocol, eligibility criteria, and contact information for NCT05646381 live on ClinicalTrials.gov.