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Recruiting Phase 1 Interventional

First in Human Study of AZD9592 in Solid Tumors

ClinicalTrials.gov ID: NCT05647122

Public ClinicalTrials.gov record NCT05647122. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.

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ClinicalTrials.gov public records Last synced May 8, 2026, 3:55 AM EDT

Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.

Official title

A Phase I, Multicenter, Open-label, First-in-Human, Dose Escalation and Expansion Study of AZD9592 as Monotherapy and in Combination With Anti-cancer Agents in Patients With Advanced Solid Tumors

Study identification

NCT ID
NCT05647122
Recruitment status
Recruiting
Study type
Interventional
Phase
Phase 1
Lead sponsor
AstraZeneca
Industry
Enrollment
403 participants

Conditions and interventions

Interventions

  • 5-Fluorouracil (5-FU) Drug
  • AZD9592 Drug
  • Bevacizumab Drug
  • Leucovorin Drug
  • Osimertinib Drug

Drug

Eligibility (public fields only)

Age range
18 Years and older
Sex
All
Healthy volunteers
Healthy volunteers not accepted

This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.

Study timeline

Start date
Dec 20, 2022
Primary completion
Oct 5, 2027
Completion
Oct 5, 2027
Last update posted
Feb 19, 2026

2022 – 2027

United States locations

U.S. sites
16
U.S. states
11
U.S. cities
13
Facility City State ZIP Site status
Research Site Duarte California 91010 Recruiting
Research Site Irvine California 92618 Withdrawn
Research Site North Haven Connecticut 06473 Recruiting
Research Site Washington D.C. District of Columbia 20016 Recruiting
Research Site Chicago Illinois 60637 Recruiting
Research Site Baltimore Maryland 21224 Recruiting
Research Site Baltimore Maryland 21231 Recruiting
Research Site Milford Massachusetts 01757 Recruiting
Research Site Mineola New York 11501 Recruiting
Research Site New York New York 10016 Recruiting
Research Site New York New York 10021 Recruiting
Research Site New York New York 10029 Recruiting
Research Site Philadelphia Pennsylvania 19104 Recruiting
Research Site Providence Rhode Island 02903 Recruiting
Research Site Houston Texas 77030 Recruiting
Research Site Fairfax Virginia 22031 Recruiting

Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.

Non-U.S. locations

This page focuses on the U.S. directory. The official record also lists 33 non-U.S. sites.

About this trial record page

What this page shows
Public field values for ClinicalTrials.gov record NCT05647122, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
What this page does not do
No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
Where the data comes from
Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
Last refresh
Last update posted Feb 19, 2026 · Synced May 8, 2026

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Open the official record

The complete protocol, eligibility criteria, and contact information for NCT05647122 live on ClinicalTrials.gov.

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