A Study to Evaluate XEN1101 as Adjunctive Therapy in Primary Generalized Tonic-Clonic Seizures

ClinicalTrials.gov ID: NCT05667142

Public ClinicalTrials.gov record NCT05667142. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.

View official ClinicalTrials.gov record → Back to search

ClinicalTrials.gov public records Last synced May 20, 2026, 10:25 AM EDT

Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.

Official title

A Randomized, Double-Blind, Placebo-Controlled, Multicenter, Phase 3 Study to Evaluate the Safety, Tolerability, and Efficacy of XEN1101 as Adjunctive Therapy in Primary Generalized Tonic-Clonic Seizures

Study identification

NCT ID: NCT05667142
Recruitment status: Recruiting
Study type: Interventional
Phase: Phase 3
Lead sponsor: Xenon Pharmaceuticals Inc.; Industry
Enrollment: 160 participants

Conditions and interventions

Conditions

Primary Generalized Tonic-Clonic Seizures

Interventions

Placebo Drug
XEN1101 Drug

Drug

Eligibility (public fields only)

Age range: 12 Years and older
Sex: All
Healthy volunteers: Healthy volunteers not accepted

This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.

Study timeline

Start date: Feb 13, 2023
Primary completion: Mar 31, 2027
Completion: May 31, 2027
Last update posted: May 14, 2026

2023 – 2027

United States locations

U.S. sites: 59
U.S. states: 28
U.S. cities: 53

Facility	City	State	ZIP	Site status
University of Alabama - Strada Patient Care Center, Neurology	Mobile	Alabama	36604	Recruiting
Xenoscience	Phoenix	Arizona	85004	Recruiting
University of Arizona - Health Science Center	Tucson	Arizona	85724	Recruiting
University of Arkansas for Medical Sciences	Little Rock	Arkansas	72205	Recruiting
Brain Science Research Institute	Los Angeles	California	90025	Recruiting
University of California, Irvine - Health Neurology Services	Orange	California	92868	Recruiting
University California, Davis Clinical & Translation Science Center Clinical Research (CCRC)	Sacramento	California	95817	Withdrawn
University of Colorado Anschutz Medical Campus	Aurora	Colorado	80045	Recruiting
Mayo Clinic Florida	Jacksonville	Florida	32224	Recruiting
Serenity Research Center, LLC	Miami	Florida	33176	Recruiting
Research Institute of Orlando, LLC	Orlando	Florida	32806	Terminated
Panhandle Research and Medical Clinic	Pensacola	Florida	32503	Recruiting
Medsol Clinical Research Center Harbor Professional Centre	Port Charlotte	Florida	33952	Recruiting
University of South Florida	Tampa	Florida	33606	Recruiting
Encore Medical Research of Weston, LLC	Weston	Florida	33331	Recruiting
Emory Brain Health Center	Atlanta	Georgia	30329	Recruiting
Children's Healthcare of Atlanta	Atlanta	Georgia	30342	Recruiting
Georgia Neurology & Sleep Medicine Associates	Suwanee	Georgia	30024	Withdrawn
Hawaii Pacific Neuroscience, Comprehensive Epilepsy Center	Honolulu	Hawaii	96817	Recruiting
Consultants in Epilepsy and Neurology, PLLC	Boise	Idaho	83702	Recruiting
Southern Illinois University School of Medicine	Springfield	Illinois	62794	Recruiting
Indiana University School of Medicine	Indianapolis	Indiana	46202	Withdrawn
University of Kansas Medical Center	Kansas City	Kansas	66160	Recruiting
Bluegrass Epilepsy Research, LLC	Lexington	Kentucky	40504	Recruiting
University of Kentucky Albert B. Chandler Hospital (UK Healthcare)	Lexington	Kentucky	40536	Recruiting
University of Maryland Medical Center	Baltimore	Maryland	21201	Recruiting
MedStar Franklin Square Medical Center	Baltimore	Maryland	21237	Recruiting
Mid-Atlantic Epilepsy and Sleep Center	Bethesda	Maryland	20817	Recruiting
Medstar Georgetown University Hospital	Clinton	Maryland	20735	Recruiting
Brigham and Women's Hospital	Chestnut Hill	Massachusetts	02467	Recruiting
UMass Memorial Medical Center	Worcester	Massachusetts	01655	Recruiting
University of Michigan Hospitals	Ann Arbor	Michigan	48109	Recruiting
Wayne State University	Detroit	Michigan	48201	Recruiting
Michigan State University Department of Neurology	East Lansing	Michigan	48824	Recruiting
Spectrum Health	Grand Rapids	Michigan	49503	Recruiting
Saint Louis University Medical School	St Louis	Missouri	14624	Recruiting
Northeast Regional Epilepsy Group	Hackensack	New Jersey	07601	Recruiting
Dent Neurosciences Research Facility	Amherst	New York	14226	Terminated
SUNY Upstate Medical University	Syracuse	New York	13201	Recruiting
Five Towns Neurology	Woodmere	New York	11598	Withdrawn
Atrium Health	Charlotte	North Carolina	28203	Recruiting
Onsite Clinical Solutions, LLC	Charlotte	North Carolina	28211	Recruiting
Duke University Clinical Research	Durham	North Carolina	27710	Recruiting
Wake Forest Baptist Health	Winston-Salem	North Carolina	27104	Recruiting
Summa Health Clinical Research Center	Akron	Ohio	44304	Recruiting
Cleveland Clinic Foundation	Cleveland	Ohio	44195	Recruiting
The Ohio State University	Columbus	Ohio	43210	Recruiting
OhioHealth Riverside Methodist Hospital	Columbus	Ohio	43214	Recruiting
University of Pennsylvania	Philadelphia	Pennsylvania	19104	Recruiting
Temple University Hospital	Philadelphia	Pennsylvania	19140	Recruiting
UPMC Comprehensive Epilepsy Center	Pittsburgh	Pennsylvania	15213	Recruiting
Medical University of South Carolina (MUSC)	Charleston	South Carolina	29425	Withdrawn
ANESC Research	El Paso	Texas	79912	Recruiting
UTHealth Science Center at Houston	Houston	Texas	77030	Recruiting
University of Texas Health Science Center at San Antonio	San Antonio	Texas	78229	Recruiting
University of Utah Clinical Neurosciences Center	Salt Lake City	Utah	84132	Active, not recruiting
Sentara Neurology Specialists	Virginia Beach	Virginia	23456	Recruiting
University of Washington, Regional Epilepsy Center at Harborview Medical Center	Seattle	Washington	98104	Recruiting
Advocate Aurora Research institute, St. Luke's Medical Center	Milwaukee	Wisconsin	53215	Recruiting

Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.

Non-U.S. locations

This page focuses on the U.S. directory. The official record also lists 79 non-U.S. sites.

About this trial record page

What this page shows: Public field values for ClinicalTrials.gov record NCT05667142, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
What this page does not do: No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
Where the data comes from: Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
Last refresh: Last update posted May 14, 2026 · Synced May 20, 2026

Open the official record

The complete protocol, eligibility criteria, and contact information for NCT05667142 live on ClinicalTrials.gov.

View official ClinicalTrials.gov record →