ClinicalTrials.gov record
REDEFINE 3: A Research Study to See the Effects of CagriSema in People Living With Diseases in the Heart and Blood Vessels
ClinicalTrials.gov ID: NCT05669755
Public ClinicalTrials.gov record NCT05669755. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
ClinicalTrials.gov public records Last synced May 6, 2026, 8:13 AM EDT
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
The Cardiovascular Safety and Efficacy of Cagrilintide 2.4 mg s.c. in Combination With Semaglutide 2.4 mg s.c. (CagriSema 2.4 mg/2.4 mg s.c.) Once-weekly in Participants With Established Cardiovascular Disease
Study identification
- NCT ID
- NCT05669755
- Recruitment status
- Active, not recruiting
- Study type
- Interventional
- Phase
- Phase 3
- Lead sponsor
- Novo Nordisk A/S
- Industry
- Enrollment
- 7,101 participants
Conditions and interventions
Conditions
Interventions
- Cagrilintide Drug
- Placebo Drug
- Semaglutide Drug
Drug
Eligibility (public fields only)
- Age range
- 55 Years and older
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Feb 28, 2023
- Primary completion
- Aug 31, 2027
- Completion
- Oct 12, 2027
- Last update posted
- Mar 11, 2026
2023 – 2027
United States locations
- U.S. sites
- 119
- U.S. states
- 31
- U.S. cities
- 105
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| Univ of Alabama Birmingham | Birmingham | Alabama | 32533 | — |
| Chambliss Clinical Trials LLC | Montgomery | Alabama | 36106 | — |
| Honor Health | Scottsdale | Arizona | 85258 | — |
| National Heart Institute Cal | Beverly Hills | California | 90211 | — |
| Valley Clinical Trials | Covina | California | 91723 | — |
| Scripps Wht Diab Inst La Jolla | La Jolla | California | 92037 | — |
| First Valley Medical Group | Lancaster | California | 93534 | — |
| Clinical Trials Research_Sacramento | Lincoln | California | 95648 | — |
| Torrance Clin Res Inst, Inc. | Lomita | California | 90717 | — |
| Pacific Clinical Studies | Los Alamitos | California | 90720 | — |
| Monterey Endocrine & Diabetes Institute, Inc | Monterey | California | 93940 | — |
| Valley Clinical Trials, Inc. | Northridge | California | 91325 | — |
| Desert Oasis Hlthcr Med Group | Palm Springs | California | 92262 | — |
| Western University of Health Sciences | Pomona | California | 91766 | — |
| Linda Vista Health Care Ctr | San Diego | California | 92111 | — |
| N America Res Inst - San Dimas | San Dimas | California | 91773 | — |
| Encompass Clinical Research_Spring Valley | Spring Valley | California | 91978 | — |
| Lundquist Inst.-Biom Inno-UCLA | Torrance | California | 90502 | — |
| Bridgeport Hospital | Bridgeport | Connecticut | 06610 | — |
| Innovative Research of W FL | Clearwater | Florida | 33756 | — |
| Florida Premier Cardiology | Delray Beach | Florida | 33445 | — |
| Fleming Island Center for Clinical Research | Fleming Island | Florida | 32003 | — |
| Life Spring Research Foundation LLC | Miami | Florida | 33130 | — |
| Clinical Trial Services Corp | Miami | Florida | 33144 | — |
| Oceane 7 Medical & Research Center, Inc. | Miami | Florida | 33144 | — |
| Reyes Clinical Research, Inc | Miami | Florida | 33174 | — |
| San Marcus Res Clin Miami Lakes | Miami Lakes | Florida | 33014 | — |
| Floridian Clinical Research, LLC | Miami Lakes | Florida | 33016 | — |
| Adult Medicine of Lake County, Inc. | Mt. Dora | Florida | 32757 | — |
| Suncoast Clinical Research, Inc. | New Port Richey | Florida | 34652 | — |
| Hanson Clinical Research Center | Port Charlotte | Florida | 33952 | — |
| Northeast Research Institute | Saint Augustine | Florida | 32080 | — |
| Cardio Partners Clin Res Inst | Wellington | Florida | 33449 | — |
| Endo Res Solutions Inc | Roswell | Georgia | 30076 | — |
| Atlanta Heart Specialists, LLC | Tucker | Georgia | 30084 | — |
| Rocky Mountain Diab&Osteo Ctr | Idaho Falls | Idaho | 83404-7596 | — |
| Northwest Heart Clinical Research, LLC | Arlington Heights | Illinois | 60005 | — |
| Macoupin Research Group | Gillespie | Illinois | 62033 | — |
| Clinical Invest Special_Gurnee | Gurnee | Illinois | 60031 | — |
| Endeavor Health | Skokie | Illinois | 60077 | — |
| American Hlth Ntwk of IN LLC | Franklin | Indiana | 46131 | — |
| West Broadway Clinic | Council Bluffs | Iowa | 51501 | — |
| Iowa Diab & Endo Res Center | West Des Moines | Iowa | 50266 | — |
| Midwest Heart & Vasc Spec | Overland Park | Kansas | 66211 | — |
| The Research Group of Lexington LLC | Lexington | Kentucky | 40503 | — |
| L-MARC Research Center | Louisville | Kentucky | 40213 | — |
| Louisiana Heart Center | Covington | Louisiana | 70433 | — |
| Louisiana Heart Center | Hammond | Louisiana | 70403 | — |
| Tulane University Health Sciences Center | New Orleans | Louisiana | 70112 | — |
| Clinical Trials Of America | West Monroe | Louisiana | 71291 | — |
| Ascension Saint Agnes Heart Ca | Baltimore | Maryland | 21229 | — |
| Elite Research Center | Flint | Michigan | 48532 | — |
| Arcturus HC PLC Troy Med Res | Troy | Michigan | 48098 | — |
| NDORI | Diamondhead | Mississippi | 39525 | — |
| StudyMetrix Research LLC | City of Saint Peters | Missouri | 63303 | — |
| Clinical Research Consultants, LLC | Kansas City | Missouri | 64111 | — |
| Clinvest Research | Springfield | Missouri | 65807 | — |
| Amicis Centers of Clinical Research | St Louis | Missouri | 63128 | — |
| St Louis Heart & Vascular, P.C. | St Louis | Missouri | 63136 | — |
| VA Neb West Iowa Hlth System | Omaha | Nebraska | 68105 | — |
| Methodist Physicians Clin | Omaha | Nebraska | 68114 | — |
| Univ of NE Med Center_Omaha | Omaha | Nebraska | 68198-6828 | — |
| Southern New Hampshire Diabetes and Endocrinology | Nashua | New Hampshire | 03063 | — |
| Renal Medicine Associates | Albuquerque | New Mexico | 87109 | — |
| Albany Medical College | Albany | New York | 12203 | — |
| Mid Hudson Med Res-New Windsor | New Windsor | New York | 12553 | — |
| IMA Clinical Research- NY | New York | New York | 10036 | — |
| Saratoga Clinical Research | Saratoga Springs | New York | 12866 | — |
| Prime Global Research Inc. | The Bronx | New York | 10456 | — |
| Southgate Medical Group, LLP | West Seneca | New York | 14224 | — |
| Great Lakes Medical Research | Westfield | New York | 14787 | — |
| UNC- Chapel Hill | Chapel Hill | North Carolina | 27599 | — |
| Duke University | Durham | North Carolina | 27710 | — |
| Carteret Medical Group | Morehead City | North Carolina | 28557 | — |
| Eastern Nephrology Associates, PLLC | New Bern | North Carolina | 28562 | — |
| Piedmont Healthcare/Research | Statesville | North Carolina | 28625 | — |
| Brookview Hills Research Associates, LLC | Winston-Salem | North Carolina | 27103 | — |
| Lillestol Research LLC | Fargo | North Dakota | 58104 | — |
| Cleveland Clinic - Main Campus | Cleveland | Ohio | 44195 | — |
| Providence Health Partners Ctr | Dayton | Ohio | 45439 | — |
| Ohio- Advanced Medical Research | Maumee | Ohio | 43537 | — |
| Heritage Valley Medical Group | Beaver | Pennsylvania | 15009 | — |
| Capital Area Research LLC | Newport | Pennsylvania | 17074 | — |
| Aria Endocrine Metabolic Assoc | Philadelphia | Pennsylvania | 19114 | — |
| Carolina Health Specialists | Myrtle Beach | South Carolina | 29572 | — |
| Univ Diab & Endo Consultants | Chattanooga | Tennessee | 37411 | — |
| PharmaTex Research | Amarillo | Texas | 79106 | — |
| Arlington Family Res. Ctr Inc | Arlington | Texas | 76012-4637 | — |
| South Texas Clinical Research | Corpus Christi | Texas | 78404 | — |
| Baylor Scott & White Res Inst | Dallas | Texas | 75226 | — |
| Velocity Clinical Res-Dallas | Dallas | Texas | 75230 | — |
| Dallas Heart and Vascular | Duncanville | Texas | 75137 | — |
| Academy of Diabetes, T&E | El Paso | Texas | 79935 | — |
| Diabetes and Thyroid Ctr of FW | Fort Worth | Texas | 76132 | — |
| Forefront Med Res Inst PLLC | Harlingen | Texas | 78550 | — |
| PrimeCare Medical Group | Houston | Texas | 77024 | — |
| Synergy Groups Medical | Houston | Texas | 77061 | — |
| Southwest Houston Research Ltd | Houston | Texas | 77099 | — |
| Prem Internal Med Asso Houston | Katy | Texas | 77493 | — |
| Radiance Clinical Research | Lampasas | Texas | 76550 | — |
| DCOL Ctr for Clin Res | Longview | Texas | 75605 | — |
| Texas Inst, Kdny & Endo Disor | Lufkin | Texas | 75904 | — |
| Texas Institute of Cardiology PA | McKinney | Texas | 75071 | — |
| Texas Diabetes & Endocrinology_Round Rock | Round Rock | Texas | 78681 | — |
| Univ Of Texas Hlth Science Cntr | San Antonio | Texas | 78207 | — |
| Clinical Advancement Center | San Antonio | Texas | 78212 | — |
| San Antonio Prem Int Med | San Antonio | Texas | 78220 | — |
| Audie L. Murphy VA Hospital | San Antonio | Texas | 78229 | — |
| Northeast Clinical Research of San Antonio | San Antonio | Texas | 78233 | — |
| Simcare Medical Research, LLC | Sugar Land | Texas | 77478 | — |
| Crossroads Clinical Res- Texas | Victoria | Texas | 77901 | — |
| Hillcrest Family Health Center | Waco | Texas | 76708 | — |
| Valley Diab. & Endo Comp Ctr | Weslaco | Texas | 78596 | — |
| York Clinical Research LLC | Norfolk | Virginia | 23540 | — |
| Dominion Medical Associates | Richmond | Virginia | 23219 | — |
| VA Medical Center_Salem | Salem | Virginia | 24153-6404 | — |
| Selma Medical Associates | Winchester | Virginia | 22601-3834 | — |
| Confluence Health Hospital | Wenatchee | Washington | 98801 | — |
| Aspirus Research Institute | Wausau | Wisconsin | 54401 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
Non-U.S. locations
This page focuses on the U.S. directory. The official record also lists 509 non-U.S. sites.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT05669755, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Mar 11, 2026 · Synced May 6, 2026
Related: full search, browse by condition, browse by drug or therapy, browse by sponsor, browse by U.S. city.
Open the official record
The complete protocol, eligibility criteria, and contact information for NCT05669755 live on ClinicalTrials.gov.