ONC-392 Plus Lutetium Lu 177 Vipivotide Tetraxetan in Patients With mCRPC
Public ClinicalTrials.gov record NCT05682443. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
Randomized Study of ONC-392 Plus Lutetium Lu 177 Vipivotide Tetraxetan in Patients With Metastatic Castration-Resistant Prostate Cancer (mCRPC) Who Progressed on Androgen Receptor (AR) Pathway Inhibition
Brief summary
Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.
In this Phase 2 study, mCRPC patients with PSMA positive scans who progressed on prior ARTA and up to 2 lines of taxanes, and are naïve to lutetium Lu 177 vipivotide tetraxetan, will be enrolled. The study is open-label, randomized with active control, multi-center study.
Study identification
- NCT ID
- NCT05682443
- Recruitment status
- Active, not recruiting
- Study type
- Interventional
- Phase
- Phase 1, Phase 2
- Enrollment
- 148 participants
Conditions and interventions
Eligibility (public fields only)
- Age range
- 18 Years and older
- Sex
- Male
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Dec 11, 2023 (Actual)
- Primary completion
- Nov 30, 2026 (Estimated)
- Completion
- Nov 30, 2027 (Estimated)
- Last update posted
- May 22, 2026
2023 – 2027
United States locations
- U.S. sites
- 23
- U.S. states
- 17
- U.S. cities
- 22
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| UC Davis Comprehensive Cancer Center | Sacramento | California | 95817 | — |
| Rocky Mountain Cancer Centers USOR | Aurora | Colorado | 80012 | — |
| Moffitt Cancer Cancer | Tampa | Florida | 33612 | — |
| Emory University Winship Cancer Institute | Atlanta | Georgia | 30322 | — |
| The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins | Baltimore | Maryland | 21202 | — |
| Chesapeake Urology Research Associates | Towson | Maryland | 21204 | — |
| Lahey Hospital & Medical Center | Burlington | Massachusetts | 01805 | — |
| University of Mississippi Medical Center | Jackson | Mississippi | 39216 | — |
| XCancer/GU Research Network | Omaha | Nebraska | 68130 | — |
| Rutgers Cancer Institute | New Brunswick | New Jersey | 08901 | — |
| New Mexico Oncology Hematology Consultants | Albuquerque | New Mexico | 87109 | — |
| Roswell Park Comprehensive Cancer Center | Buffalo | New York | 14203 | — |
| NYU Langone Health, Laura & Isaac Perlmutter Cancer Center | New York | New York | 10016 | — |
| Columbia University Irving Cancer Center | New York | New York | 10032 | — |
| UNC North Carolina Comprehensive Cancer Care Center | Chapel Hill | North Carolina | 27514 | — |
| Duke Cancer Center | Durham | North Carolina | 27710 | — |
| The Ohio State University Comprehensive Cancer Center | Columbus | Ohio | 43210 | — |
| OHSU Knight Cancer Institute | Portland | Oregon | 97210 | — |
| UT Southwestern Medical Center | Dallas | Texas | 75390 | — |
| Virginia Cancer Specialists USOR | Fairfax | Virginia | 22031 | — |
| Virginia Oncology Associates USOR | Norfolk | Virginia | 23502 | — |
| Oncology and Hematology Associates Of Southwest Virginia USOR | Norton | Virginia | 24273 | — |
| UW Carbone Cancer Center | Madison | Wisconsin | 53792 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT05682443, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted May 22, 2026 · Synced Sep 30, 2026
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Open the official record
The complete public registry record, listed eligibility criteria, and available contact information for NCT05682443 live on ClinicalTrials.gov.