ALT-FLOW II Trial of the Edwards APTURE Transcatheter Shunt System

ClinicalTrials.gov ID: NCT05686317

Public ClinicalTrials.gov record NCT05686317. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.

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ClinicalTrials.gov public records Last synced Oct 28, 2026, 6:15 AM EDT

Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.

Official title

A Randomized, Sham-controlled Clinical Trial for Evaluation of the Edwards APTURE Transcatheter Shunt System (ALT-FLOW II)

Brief summary

Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.

This is a prospective, multi-center, randomized, sham-controlled, double-blinded (participant and outcomes assessor) clinical trial.

Study identification

NCT ID: NCT05686317
Recruitment status: Active, not recruiting
Study type: Interventional
Phase: Not applicable
Lead sponsor: Edwards Lifesciences; Industry
Enrollment: 100 participants

Conditions and interventions

Conditions

Heart Failure

Interventions

Edwards APTURE transcatheter shunt system Device
Sham procedure Diagnostic Test

Device · Diagnostic Test

Eligibility (public fields only)

Age range: 18 Years and older
Sex: All
Healthy volunteers: Healthy volunteers not accepted

This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.

Study timeline

Start date: Apr 1, 2023 (Actual)
Primary completion: Nov 1, 2026 (Estimated)
Completion: Aug 31, 2030 (Estimated)
Last update posted: Jun 4, 2026

2023 – 2030

United States locations

U.S. sites: 17
U.S. states: 10
U.S. cities: 16

Facility	City	State	ZIP	Site status
University of California Irvine	Irvine	California	92868	—
University of California San Diego	La Jolla	California	92027	—
Scripps Health	La Jolla	California	92037	—
University of Southern California	Los Angeles	California	90033	—
University of California San Francisco	San Francisco	California	94143	—
Ascension Illinois Heart and Vascular Medical Group	Elk Grove	Illinois	60007	—
Kansas University Medical Center	Kansas City	Kansas	66160	—
Abbott Northwestern Hospital	Minneapolis	Minnesota	55407	—
Mayo Clinic	Rochester	Minnesota	55902	—
St. Francis Hospital & Heart Center	Roslyn	New York	11576	—
Montefiore Medical Center	The Bronx	New York	10467	—
The Christ Hospital	Cincinnati	Ohio	45219	—
The Ohio State University	Columbus	Ohio	43210	—
Oklahoma Heart Institute	Tulsa	Oklahoma	74104	—
Oregon Health and Science University	Oregon City	Oregon	97239	—
Lankenau Medical Center	Wynnewood	Pennsylvania	19096	—
Medical University of South Carolina Charleston	Charleston	South Carolina	29425'	—

Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.

Non-U.S. locations

This page focuses on the U.S. directory. The official record also lists 8 non-U.S. sites.

About this trial record page

What this page shows: Public field values for ClinicalTrials.gov record NCT05686317, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
What this page does not do: No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
Where the data comes from: Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
Last refresh: Last update posted Jun 4, 2026 · Synced Oct 28, 2026

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The complete public registry record, listed eligibility criteria, and available contact information for NCT05686317 live on ClinicalTrials.gov.

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