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Recruiting Phase 1 Interventional

Studying the Safety and Determining the Optimal Dose of Novobiocin in Patients With Tumors That Have Alterations in DNA Repair Genes

ClinicalTrials.gov ID: NCT05687110

Public ClinicalTrials.gov record NCT05687110. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.

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ClinicalTrials.gov public records Last synced Sep 11, 2026, 5:01 PM EDT

Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.

Official title

A Phase 1 Study of the Polymerase Theta (POLθ) Inhibitor Novobiocin in BRCA- Mutant and Other DNA Damage Repair-Deficient Solid Tumors

Brief summary

Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.

This phase I trial tests the safety, side effects, and best dose of novobiocin in treating cancer patients with alterations in deoxyribonucleic acid (DNA) repair genes. Novobiocin is an antibiotic that blocks the activity of a protein called DNA polymerase theta, which helps repair DNA that has become damaged as cells grow and divide. Cancer cells that cannot repair their damaged DNA die. This medication may help shrink or stabilize cancer with a mutation in DNA repair genes.

Study identification

NCT ID
NCT05687110
Recruitment status
Recruiting
Study type
Interventional
Phase
Phase 1
Enrollment
43 participants

Conditions and interventions

Interventions

Procedure · Biological

Eligibility (public fields only)

Age range
18 Years and older
Sex
All
Healthy volunteers
Healthy volunteers not accepted

This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.

Study timeline

Start date
Jul 5, 2023
Primary completion
Jun 30, 2028
Completion
Jun 30, 2028
Last update posted
Aug 2, 2026

2023 – 2028

United States locations

U.S. sites
22
U.S. states
10
U.S. cities
17
Facility City State ZIP Site status
City of Hope Comprehensive Cancer Center Duarte California 91010 Recruiting
UCI Health - Chao Family Comprehensive Cancer Center and Ambulatory Care Irvine California 92612 Active, not recruiting
UC San Diego Moores Cancer Center La Jolla California 92093 Recruiting
Los Angeles General Medical Center Los Angeles California 90033 Recruiting
USC / Norris Comprehensive Cancer Center Los Angeles California 90033 Recruiting
UC Irvine Health/Chao Family Comprehensive Cancer Center Orange California 92868 Active, not recruiting
University of California Davis Comprehensive Cancer Center Sacramento California 95817 Active, not recruiting
UC San Diego Medical Center - Hillcrest San Diego California 92103 Recruiting
University of Chicago Comprehensive Cancer Center Chicago Illinois 60637 Recruiting
National Cancer Institute Developmental Therapeutics Clinic Bethesda Maryland 20892 Recruiting
National Institutes of Health Clinical Center Bethesda Maryland 20892 Active, not recruiting
Beth Israel Deaconess Medical Center Boston Massachusetts 02215 Recruiting
Dana-Farber Cancer Institute Boston Massachusetts 02215 Recruiting
NYU Langone Hospital - Long Island Mineola New York 11501 Recruiting
Laura and Isaac Perlmutter Cancer Center at NYU Langone New York New York 10016 Recruiting
Ohio State University Comprehensive Cancer Center Columbus Ohio 43210 Recruiting
University of Oklahoma Health Sciences Center Oklahoma City Oklahoma 73104 Recruiting
Huntsman Cancer Institute/University of Utah Salt Lake City Utah 84112 Recruiting
Fred Hutchinson Cancer Center Seattle Washington 98109 Recruiting
University of Washington Medical Center - Montlake Seattle Washington 98195 Recruiting
University of Wisconsin Carbone Cancer Center - Eastpark Medical Center Madison Wisconsin 53718 Recruiting
University of Wisconsin Carbone Cancer Center - University Hospital Madison Wisconsin 53792 Recruiting

Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.

Non-U.S. locations

This page focuses on the U.S. directory. The official record also lists 1 non-U.S. site.

About this trial record page

What this page shows
Public field values for ClinicalTrials.gov record NCT05687110, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
What this page does not do
No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
Where the data comes from
Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
Last refresh
Last update posted Aug 2, 2026 · Synced Sep 11, 2026

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Open the official record

The complete protocol, eligibility criteria, and contact information for NCT05687110 live on ClinicalTrials.gov.

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