DEFIANCE: RCT of ClotTriever System Versus Anticoagulation In Deep Vein Thrombosis

ClinicalTrials.gov ID: NCT05701917

Public ClinicalTrials.gov record NCT05701917. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.

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ClinicalTrials.gov public records Last synced May 6, 2026, 8:41 AM EDT

Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.

Official title

DEFIANCE - ClotTriever® Thrombectomy System vs. Anticoagulation Alone for Treatment of Deep Vein Thrombosis

Study identification

NCT ID: NCT05701917
Recruitment status: Recruiting
Study type: Interventional
Phase: Not applicable
Lead sponsor: Inari Medical; Industry
Enrollment: 300 participants

Conditions and interventions

Conditions

Interventions

ClotTriever System Device
Commercially available/market approved anticoagulation medication including but not limited to: Heparin Sodium, Coumadin, Rivaroxaban, Apixaban, etc. Drug

Device · Drug

Eligibility (public fields only)

Age range: 18 Years and older
Sex: All
Healthy volunteers: Healthy volunteers not accepted

This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.

Study timeline

Start date: Jan 5, 2023
Primary completion: Jun 29, 2026
Completion: Jan 14, 2027
Last update posted: Apr 30, 2026

2023 – 2027

United States locations

U.S. sites: 48
U.S. states: 26
U.S. cities: 46

Facility	City	State	ZIP	Site status
Honor Health	Scottsdale	Arizona	85258	Recruiting
Pima Heart and Vascular	Tucson	Arizona	85704	Recruiting
UCI Medical Center	Orange	California	92868	Recruiting
Vascular and Interventional Specialists of Orange County	Orange	California	92868	Recruiting
Huntington Health	Pasadena	California	91105	Recruiting
University Of Colorado	Denver	Colorado	80045	Recruiting
Yale University	New Haven	Connecticut	06520	Recruiting
MedStar Health Research Institution	Washington D.C.	District of Columbia	20010	Recruiting
Manatee Memorial Hospital	Bradenton	Florida	34208	Terminated
Baptist Health Research Institute	Jacksonville	Florida	32207	Recruiting
Lakeland Vascular Institute	Lakeland	Florida	33805	Terminated
HCA Florida Largo Hospital	Largo	Florida	33770	Recruiting
Sarasota Memorial Hospital	Sarasota	Florida	34239	Recruiting
BayCare Health System	Tampa	Florida	33607	Recruiting
Memorial Health University Medical Center	Savannah	Georgia	31404	Terminated
Community Healthcare System	Munster	Indiana	46321	Terminated
St. Elizabeth Edgewood	Edgewood	Kentucky	41017	Terminated
University of Maryland	Baltimore	Maryland	21201	Recruiting
McLaren Healthcare	Bay City	Michigan	48708	Recruiting
Henry Ford Health	Detroit	Michigan	48202	Recruiting
MyMichigan Medical Center	Midland	Michigan	48670	Recruiting
University of Missouri	Columbia	Missouri	65212	Recruiting
Saint Luke's Hospital of Kansas City	Kansas City	Missouri	64131	Terminated
St. Louis University	St Louis	Missouri	63104	Recruiting
University Medical Center of Southern Nevada	Las Vegas	Nevada	89102	Recruiting
Cooper University Hospital	Camden	New Jersey	08103	Recruiting
Holy Name Medical Center	Teaneck	New Jersey	07666	Terminated
Northwell Health	Bay Shore	New York	11706	Recruiting
NYP-Brooklyn Methodist	Brooklyn	New York	11215	Recruiting
SUNY, The University at Buffalo	Buffalo	New York	14203	Terminated
NYU Langone Medical Center	New York	New York	10016	Recruiting
Columbia University Irving Medical Center	New York	New York	10032	Recruiting
Mission Health	Asheville	North Carolina	28801	Terminated
Mercy Health - The Heart Institute	Cincinnati	Ohio	45211	Terminated
Cleveland Clinic	Cleveland	Ohio	44195	Recruiting
Saint Francis Hospital	Tulsa	Oklahoma	74136	Recruiting
Allegheny St. Vincent Hospital	Erie	Pennsylvania	16544	Recruiting
Thomas Jefferson University	Philadelphia	Pennsylvania	19107	Recruiting
Allegheny General Health Research Network	Pittsburgh	Pennsylvania	15212	Recruiting
Rhode Island Hospital	Providence	Rhode Island	02903	Recruiting
Prisma Health Upstate	Greenville	South Carolina	29615	Terminated
Spartanburg Medical Center	Spartanburg	South Carolina	29303	Recruiting
Lexington Medical Center	West Columbia	South Carolina	29169	Terminated
Vanderbilt University Medical Center	Nashville	Tennessee	37232	Recruiting
Clements University Hospital (UTSW)	Dallas	Texas	75390	Recruiting
Sentara Norfolk General Hospital	Norfolk	Virginia	23507	Recruiting
Providence Sacred Heart Med Center	Spokane	Washington	99204	Terminated
Aurora St. Luke's Medical Center	Milwaukee	Wisconsin	53215	Terminated

Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.

Non-U.S. locations

This page focuses on the U.S. directory. The official record also lists 16 non-U.S. sites.

About this trial record page

What this page shows: Public field values for ClinicalTrials.gov record NCT05701917, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
What this page does not do: No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
Where the data comes from: Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
Last refresh: Last update posted Apr 30, 2026 · Synced May 6, 2026

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The complete protocol, eligibility criteria, and contact information for NCT05701917 live on ClinicalTrials.gov.

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