ClinicalTrials.gov record
Active, not recruiting Not applicable Interventional

Comparing Single vs Multiple Dose Radiation for Cancer Patients With Brain Metastasis and Receiving Immunotherapy

ClinicalTrials.gov ID: NCT05703269

Public ClinicalTrials.gov record NCT05703269. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.

ClinicalTrials.gov public records Last synced May 20, 2026, 10:23 AM EDT

Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.

Official title

Hypofractionated Radiotherapy vs Single Fraction Radiosurgery for Brain Metastasis Patients on Immunotherapy (HYPOGRYPHE)

Study identification

NCT ID
NCT05703269
Recruitment status
Active, not recruiting
Study type
Interventional
Phase
Not applicable
Lead sponsor
Wake Forest University Health Sciences
Other
Enrollment
58 participants

Conditions and interventions

Interventions

  • fractionated stereotactic radiosurgery (FSRS) Radiation
  • single fraction stereotactic radiosurgery (SSRS) Radiation

Radiation

Eligibility (public fields only)

Age range
18 Years and older
Sex
All
Healthy volunteers
Healthy volunteers not accepted

This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.

Study timeline

Start date
Jul 10, 2023
Primary completion
Mar 30, 2028
Completion
Mar 30, 2028
Last update posted
Apr 5, 2026

2023 – 2028

United States locations

U.S. sites
34
U.S. states
11
U.S. cities
29
Facility City State ZIP Site status
Lewis Cancer and Research Pavilion at Saint Joseph's/Candler Savannah Georgia 31405
Decatur Memorial Hospital Decatur Illinois 62526
Crossroads Cancer Center Effingham Illinois 62401
HSHS Saint Elizabeth's Hospital O'Fallon Illinois 62269
OSF Saint Francis Medical Center Peoria Illinois 61637
Trinity Health Saint Joseph Mercy Hospital Ann Arbor Ann Arbor Michigan 48106
Trinity Health IHA Medical Group Hematology Oncology - Brighton Brighton Michigan 48114
Genesys Hurley Cancer Institute Flint Michigan 48503
Trinity Health Saint Mary Mercy Livonia Hospital Livonia Michigan 48154
Trinity Health IHA Medical Group Hematology Oncology Ann Arbor Campus Ypsilanti Michigan 48197
Mercy Hospital Springfield Springfield Missouri 65804
Mercy Hospital South St Louis Missouri 63128
Lovelace Medical Center-Saint Joseph Square Albuquerque New Mexico 87102
Lovelace Radiation Oncology Albuquerque New Mexico 87109
Carolinas Medical Center/Levine Cancer Institute Charlotte North Carolina 28203
Atrium Health Cabarrus/LCI-Concord Concord North Carolina 28025
Wake Forest University Health Sciences Winston-Salem North Carolina 27157
Sanford Broadway Medical Center Fargo North Dakota 58122
Sanford Roger Maris Cancer Center Fargo North Dakota 58122
Mercy Health - Perrysburg Hospital Perrysburg Ohio 43551
Saint Joseph's/Candler - Bluffton Campus Bluffton South Carolina 29910
Saint Francis Hospital Greenville South Carolina 29601
Prisma Health Cancer Institute - Faris Greenville South Carolina 29605
Saint Francis Cancer Center Greenville South Carolina 29607
Gibbs Cancer Center-Pelham Greer South Carolina 29651
Spartanburg Medical Center Spartanburg South Carolina 29303
Sanford Cancer Center Oncology Clinic Sioux Falls South Dakota 57104
Sanford USD Medical Center - Sioux Falls Sioux Falls South Dakota 57117-5134
Aspirus Langlade Hospital Antigo Wisconsin 54409
Saint Vincent Hospital Cancer Center Green Bay Green Bay Wisconsin 54301
Aspirus Cancer Care - James Beck Cancer Center Rhinelander Wisconsin 54501
Aspirus Cancer Care - Stevens Point Stevens Point Wisconsin 54481
Aspirus Regional Cancer Center Wausau Wisconsin 54401
Aspirus Cancer Care - Wisconsin Rapids Wisconsin Rapids Wisconsin 54494

Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.

About this trial record page

What this page shows
Public field values for ClinicalTrials.gov record NCT05703269, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
What this page does not do
No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
Where the data comes from
Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
Last refresh
Last update posted Apr 5, 2026 · Synced May 20, 2026

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Open the official record

The complete protocol, eligibility criteria, and contact information for NCT05703269 live on ClinicalTrials.gov.

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