Efficacy, Safety, and Pharmacokinetics of Vericiguat in Pediatric Participants With Heart Failure Due to Left Ventricular Systolic Dysfunction (MK-1242-036)
Public ClinicalTrials.gov record NCT05714085. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
A Phase 2/3 Randomized, Placebo-Controlled, Double-blind, Clinical Study to Evaluate the Efficacy, Safety, and Pharmacokinetics of Vericiguat in Pediatric Participants With Heart Failure Due to Systemic Left Ventricular Systolic Dysfunction (VALOR)
Study identification
- NCT ID
- NCT05714085
- Recruitment status
- Recruiting
- Study type
- Interventional
- Phase
- Phase 2, Phase 3
- Lead sponsor
- Merck Sharp & Dohme LLC
- Industry
- Enrollment
- 342 participants
Conditions and interventions
Interventions
- Placebo suspension Drug
- Placebo tablet Drug
- Vericiguat suspension Drug
- Vericiguat tablet Drug
Drug
Eligibility (public fields only)
- Age range
- 29 Days to 17 Years
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- May 30, 2023
- Primary completion
- Apr 14, 2032
- Completion
- Apr 14, 2032
- Last update posted
- Apr 19, 2026
2023 – 2032
United States locations
- U.S. sites
- 20
- U.S. states
- 14
- U.S. cities
- 20
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| The Regents of the University of California - Los Angeles (UCLA Pediatrics) ( Site 0002) | Los Angeles | California | 90095 | Recruiting |
| Lucile Packard Children's Hospital ( Site 0040) | Palo Alto | California | 94304 | Recruiting |
| Loma Linda University Health System ( Site 0008) | San Bernardino | California | 92408 | Recruiting |
| Children's Hospital Colorado ( Site 0012) | Aurora | Colorado | 80045 | Recruiting |
| Children's National Medical Center ( Site 0020) | Washington D.C. | District of Columbia | 20010 | Recruiting |
| Johns Hopkins All Children's Hospital ( Site 0029) | St. Petersburg | Florida | 33701 | Recruiting |
| Children's Healthcare of Atlanta - Arthur M. Blank Hospital ( Site 0001) | Atlanta | Georgia | 30329 | Recruiting |
| Boston Children's Hospital ( Site 0035) | Boston | Massachusetts | 02115 | Recruiting |
| C.S. Mott Children's Hospital ( Site 0033) | Ann Arbor | Michigan | 48109 | Recruiting |
| Washington University-Pediatric Cardiology/ St. Louis Children's Hospital ( Site 0006) | St Louis | Missouri | 63110 | Recruiting |
| Columbia University Medical Center-Pediatric Cardiology ( Site 0016) | New York | New York | 10032 | Recruiting |
| The Children's Hospital at Montefiore ( Site 0030) | The Bronx | New York | 10467 | Recruiting |
| Cincinnati Children's Hospital Medical Center ( Site 0034) | Cincinnati | Ohio | 45229 | Recruiting |
| Cleveland Clinic-Cleveland Clinic Chidren's ( Site 0022) | Cleveland | Ohio | 44195 | Recruiting |
| Children's Hospital of Philadelphia (CHOP) ( Site 0004) | Philadelphia | Pennsylvania | 19104 | Recruiting |
| Children's Hospital of Pittsburgh ( Site 0010) | Pittsburgh | Pennsylvania | 15224 | Recruiting |
| Le Bonheur Children's Hospital ( Site 0007) | Memphis | Tennessee | 38103 | Recruiting |
| Children's Health-The Heart Center ( Site 0015) | Dallas | Texas | 75235 | Recruiting |
| Texas Children's Hospital ( Site 0039) | Houston | Texas | 77030 | Recruiting |
| Seattle Children's Hospital-Cardiology/Fetal Therapy ( Site 0019) | Seattle | Washington | 98105 | Recruiting |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
Non-U.S. locations
This page focuses on the U.S. directory. The official record also lists 85 non-U.S. sites.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT05714085, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Apr 19, 2026 · Synced May 5, 2026
Related: full search, browse by condition, browse by drug or therapy, browse by sponsor, browse by U.S. city.
Open the official record
The complete protocol, eligibility criteria, and contact information for NCT05714085 live on ClinicalTrials.gov.