A Research Study on How Well Semaglutide Helps Children and Teenagers With Excess Body Weight Lose Weight
Public ClinicalTrials.gov record NCT05726227. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
Long-term Safety and Efficacy of Semaglutide s.c. Once-weekly on Weight Management in Children and Adolescents (Aged 6 to <18 Years) With Obesity or Overweight
Brief summary
Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.
This study will look at how well semaglutide helps children and teenagers losing weight. This will be tested by comparing the effect on body weight in children and teenagers taking semaglutide in comparison to placebo, a "dummy" medicine. In addition to taking the medicine, the child's parent and the child will have talks with study staff about healthy food choices, how to be more physically active and what your child can do to try to lose weight. The child will either get semaglutide or a "dummy" medicine. Which treatment the child will get is decided by chance. Semaglutide is an approved medicine for type 2 diabetes and weight management in adults. The child will get one injection once a week. The study medicine is injected with a thin needle in the stomach, thighs or upper arms. The study will last for about 2 ½ years (132 weeks).
Study identification
- NCT ID
- NCT05726227
- Recruitment status
- Active, not recruiting
- Study type
- Interventional
- Phase
- Phase 3
- Enrollment
- 212 participants
Conditions and interventions
Conditions
Eligibility (public fields only)
- Age range
- 6 Years to 18 Years
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Jul 7, 2023 (Actual)
- Primary completion
- Oct 15, 2025 (Actual)
- Completion
- Dec 7, 2026 (Estimated)
- Last update posted
- Oct 7, 2026
2023 – 2026
United States locations
- U.S. sites
- 24
- U.S. states
- 18
- U.S. cities
- 22
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| Neighborhood Healthcare | Escondido | California | 92025 | — |
| Yale School of Medicine | New Haven | Connecticut | 06519 | — |
| Columbus Research Foundation | Columbus | Georgia | 31904 | — |
| Eastside Bariatric and Gen Surg | Snellville | Georgia | 30078 | — |
| Solaris Clinical Research | Meridian | Idaho | 83646 | — |
| Pennington Biom Res Ctr | Baton Rouge | Louisiana | 70808 | — |
| Clinical Trials of America LLC | Monroe | Louisiana | 71201 | — |
| IMA Clinical Research | Monroe | Louisiana | 71201 | — |
| Barry J. Reiner, MD LLC | Baltimore | Maryland | 21229 | — |
| Massachusetts General Hospital_Cary | Boston | Massachusetts | 02114 | — |
| University of Minnesota | Minneapolis | Minnesota | 55414 | — |
| Mississippi Center for Advanced Medicine | Madison | Mississippi | 39110 | — |
| Mississippi CTR for ADV MED | Madison | Mississippi | 39110 | — |
| UBMD Peds-Div of Endo/Diabetes | Buffalo | New York | 14203 | — |
| WakeMed Childn Endo-Dbt_Raleig | Raleigh | North Carolina | 27610 | — |
| Valley Weight Loss Clinic | Fargo | North Dakota | 58104 | — |
| Centricity Research - Ohio | Columbus | Ohio | 43213 | — |
| UPMC Child Hosp-Pittsburgh | Pittsburgh | Pennsylvania | 15224 | — |
| Vanderbilt University Medical Center | Nashville | Tennessee | 37212 | — |
| Pediatric Clinical Trials, LLC | Tullahoma | Tennessee | 37388 | — |
| Texas Diabetes & Endocrinology | Austin | Texas | 78731 | — |
| Univ Of Texas Hlth Science Cntr | San Antonio | Texas | 78207 | — |
| Health Res of Hampton Roads | Newport News | Virginia | 23606 | — |
| Marshfield Clinic | Marshfield | Wisconsin | 54449 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
Non-U.S. locations
This page focuses on the U.S. directory. The official record also lists 32 non-U.S. sites.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT05726227, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Oct 7, 2026 · Synced Oct 26, 2026
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Open the official record
The complete public registry record, listed eligibility criteria, and available contact information for NCT05726227 live on ClinicalTrials.gov.