Evaluation of Tonabersat for DME
Public ClinicalTrials.gov record NCT05727891. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
A Phase 2 Evaluation of Tonabersat for Diabetic Macular Edema (Protocol AN)
Brief summary
Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.
This randomized clinical trial will evaluate the effect of tonabersat compared with placebo on central subfield thickness (CST) in eyes with center-involved diabetic macular edema (CI-DME) and good visual acuity.
Study identification
- NCT ID
- NCT05727891
- Recruitment status
- Active, not recruiting
- Study type
- Interventional
- Phase
- Phase 2
- Enrollment
- 128 participants
Conditions and interventions
Conditions
Eligibility (public fields only)
- Age range
- 18 Years and older
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- May 2, 2023 (Actual)
- Primary completion
- Jun 27, 2025 (Actual)
- Completion
- Jan 2026 (Estimated)
- Last update posted
- Dec 11, 2025
2023 – 2026
United States locations
- U.S. sites
- 28
- U.S. states
- 15
- U.S. cities
- 26
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| Retina Associates of Southern California | Huntington Beach | California | 92647 | — |
| Loma Linda University | Loma Linda | California | 92354 | — |
| East Bay Retina Consultants, Inc. | Oakland | California | 94609 | — |
| Southern California Desert Retina Consultants, Inc. | Palm Desert | California | 92211 | — |
| Macula Retina Vitreous Institute | Torrance | California | 90503 | — |
| National Ophthalmic Research Institute | Fort Myers | Florida | 33912 | — |
| University of Florida- Jacksonville | Jacksonville | Florida | 32209 | — |
| Central Florida Retina Institute | Lakeland | Florida | 33805 | — |
| Florida Retina Consultants | Lakeland | Florida | 33805 | — |
| Southeast Eye Institute, P.A. dba Eye Associates of Pinellas | Pinellas Park | Florida | 33782 | — |
| Southeast Retina Center | Augusta | Georgia | 30909 | — |
| Thomas Eye Group | Sandy Springs | Georgia | 30328 | — |
| Illinois Retina Associates | Oak Park | Illinois | 60304 | — |
| Midwest Eye Institute | Indianapolis | Indiana | 46290 | — |
| Joseph E. Humble and Raymond Haik PTRS DBA Eye Assoc of Northeast Louisiana | West Monroe | Louisiana | 71291 | — |
| Elman Retina Group | Baltimore | Maryland | 21237 | — |
| Boston Medical Center Corporation | Boston | Massachusetts | 02118 | — |
| Joslin Diabetes Center | Boston | Massachusetts | 02215 | — |
| Mayo Clinic | Rochester | Minnesota | 55905 | — |
| Retina Research Institute, LLC | St Louis | Missouri | 63128 | — |
| Retina-Vitreous Surgeons of Central NY, PC | Liverpool | New York | 13088 | — |
| Verum Research LLC | Eugene | Oregon | 97401 | — |
| The Trustees of the University of Pennsylvania | Philadelphia | Pennsylvania | 19104 | — |
| Pittsburg Clinical Trial Consortium | Sewickley | Pennsylvania | 15143 | — |
| Hilton Head Retina Institute | Hilton Head Island | South Carolina | 29926 | — |
| Retina Consultants of Texas, PA | Bellaire | Texas | 77401 | — |
| Texas Retina Associates | Lubbock | Texas | 79424 | — |
| Retinal Consultants of Texas | San Antonio | Texas | 78240 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT05727891, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Dec 11, 2025 · Synced Oct 30, 2026
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Open the official record
The complete public registry record, listed eligibility criteria, and available contact information for NCT05727891 live on ClinicalTrials.gov.