A Study to Investigate the Safety and Tolerability of Ziftomenib in Combination With Venetoclax/Azacitidine, Venetoclax, 7+3, or 7+3+Quizartinib in Patients With AML

ClinicalTrials.gov ID: NCT05735184

Public ClinicalTrials.gov record NCT05735184. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.

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ClinicalTrials.gov public records Last synced Apr 22, 2026, 8:33 AM EDT

Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.

Official title

Phase 1 Study of Venetoclax/Azacitidine or Venetoclax in Combination With Ziftomenib or Standard Induction Cytarabine/Daunorubicin (7+3) Chemotherapy in Combination With Ziftomenib for the Treatment of Patients With Acute Myeloid Leukemia

Study identification

NCT ID: NCT05735184
Recruitment status: Recruiting
Study type: Interventional
Phase: Phase 1
Lead sponsor: Kura Oncology, Inc.; Industry
Enrollment: 420 participants

Conditions and interventions

Conditions

Interventions

Azacitidine Drug
Cytarabine Drug
Daunorubicin Drug
Quizartinib Drug
Venetoclax Drug
Ziftomenib Drug

Drug

Eligibility (public fields only)

Age range: 18 Years and older
Sex: All
Healthy volunteers: Not listed

This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.

Study timeline

Start date: Jul 17, 2023
Primary completion: Mar 31, 2030
Completion: Mar 31, 2030
Last update posted: Mar 12, 2026

2023 – 2030

United States locations

U.S. sites: 44
U.S. states: 24
U.S. cities: 39

Facility	City	State	ZIP	Site status
Mayo Clinic - Phoenix	Phoenix	Arizona	85054	Recruiting
Moores UC San Diego Cancer Center	La Jolla	California	92093	Recruiting
USC / Norris Comprehensive Cancer Center	Los Angeles	California	90033	Recruiting
UCLA - Bowyer Oncology Center	Los Angeles	California	90095	Recruiting
UC Irvine Health Chao Family Comprehensive Cancer Center	Orange	California	92868	Recruiting
University of Colorado	Aurora	Colorado	80045	Recruiting
Colorado Blood Cancer Institute	Denver	Colorado	80218	Recruiting
Yale Cancer Center and Smilow Cancer Hospital	New Haven	Connecticut	06510	Recruiting
Mayo Clinic Jacksonville	Jacksonville	Florida	32224	Recruiting
Emory Healthcare - The Emory Clinic	Atlanta	Georgia	30308	Recruiting
Georgia Cancer Center at Augusta University	Augusta	Georgia	30912	Recruiting
Robert H. Lurie Comprehensive Cancer Center of Northwestern University	Chicago	Illinois	60611	Recruiting
Loyola University Medical Center	Maywood	Illinois	60153	Recruiting
University of Iowa Hospitals & Clinics	Iowa City	Iowa	52242	Recruiting
The University of Kansas Medical Center Research Institute	Fairway	Kansas	66205	Recruiting
University of Kentucky Markey Cancer Center	Louisville	Kentucky	40202	Recruiting
Norton Cancer Institute - St. Matthews	Louisville	Kentucky	40207	Recruiting
Ochsner MD Anderson Cancer Center	Jefferson	Louisiana	70121	Recruiting
Johns Hopkins School of Medicine	Baltimore	Maryland	21205	Recruiting
Massachusetts General Hospital	Boston	Massachusetts	02114	Recruiting
UMass Chan Medical School	Worcester	Massachusetts	01655	Recruiting
University of Michigan Comprehensive Cancer Center	Ann Arbor	Michigan	48109	Recruiting
Karmanos Cancer Institute	Detroit	Michigan	48201	Recruiting
University of Minnesota	Minneapolis	Minnesota	55455	Recruiting
Mayo Clinic - Rochester	Rochester	Minnesota	55905	Recruiting
Hackensack University Medical Center	Hackensack	New Jersey	07601	Recruiting
Rutgers Cancer Institute	New Brunswick	New Jersey	08903	Recruiting
Roswell Park Comprehensive Cancer Center	Buffalo	New York	14203	Recruiting
New York - Presbyterian / Weill Cornell Medicine	New York	New York	10021	Recruiting
Mount Sinai - Ruttenberg Treatment Center	New York	New York	10029	Recruiting
Columbia University Medical Center	New York	New York	10032	Recruiting
Stony Brook University Hospital	Stony Brook	New York	11794	Recruiting
Duke Blood Cancer Center	Durham	North Carolina	27705	Recruiting
University Hospitals Cleveland Medical Center	Cleveland	Ohio	44106	Recruiting
Cleveland Clinic Taussig Cancer Institute	Cleveland	Ohio	44195	Recruiting
The James Cancer Hospital and Solove Research Institute	Columbus	Ohio	43210	Recruiting
OU Health Stephenson Cancer Center	Oklahoma City	Oklahoma	73104	Recruiting
Hospital of the University of Pennsylvania	Philadelphia	Pennsylvania	19104	Recruiting
TriStar Bone Marrow Transplant	Nashville	Tennessee	37203	Recruiting
Sarah Cannon Research Institute - St. David's South Austin Medical Center / Texas Oncology South Austin	Austin	Texas	78704	Recruiting
UT Southwestern - Simmons Cancer Center	Dallas	Texas	75235	Recruiting
MD Anderson Cancer Center	Houston	Texas	77030	Recruiting
University of Wisconsin Hospital and Clinics	Madison	Wisconsin	53792	Recruiting
Medical College of Wisconsin Cancer Center	Milwaukee	Wisconsin	53226	Recruiting

Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.

About this trial record page

What this page shows: Public field values for ClinicalTrials.gov record NCT05735184, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
What this page does not do: No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
Where the data comes from: Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
Last refresh: Last update posted Mar 12, 2026 · Synced Apr 22, 2026

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The complete protocol, eligibility criteria, and contact information for NCT05735184 live on ClinicalTrials.gov.

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