Study of Efficacy and Safety of Iptacopan in Participants With IC-MPGN

ClinicalTrials.gov ID: NCT05755386

Public ClinicalTrials.gov record NCT05755386. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.

View official ClinicalTrials.gov record → Back to search

ClinicalTrials.gov public records Last synced May 5, 2026, 6:21 AM EDT

Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.

Official title

A Multicenter, Randomized, Double-blind, Parallel Group, Placebo-controlled Study to Evaluate the Efficacy and Safety of Iptacopan (LNP023) in Idiopathic Immune-complex-mediated Membranoproliferative Glomerulonephritis (IC-MPGN)

Study identification

NCT ID: NCT05755386
Recruitment status: Recruiting
Study type: Interventional
Phase: Phase 3
Lead sponsor: Novartis Pharmaceuticals; Industry
Enrollment: 106 participants

Conditions and interventions

Conditions

IC-MPGN

Interventions

Placebo Drug
iptacopan Drug

Drug

Eligibility (public fields only)

Age range: 12 Years to 60 Years
Sex: All
Healthy volunteers: Healthy volunteers not accepted

This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.

Study timeline

Start date: Oct 1, 2023
Primary completion: Oct 26, 2028
Completion: May 30, 2029
Last update posted: Apr 28, 2026

2023 – 2029

United States locations

U.S. sites: 21
U.S. states: 15
U.S. cities: 20

Facility	City	State	ZIP	Site status
Ronald Reagan UCLA Medical Center	Los Angeles	California	90095	Recruiting
Univ Cali Irvine ALS Neuromuscular	Orange	California	92868	Recruiting
UCSF	San Francisco	California	94115	Recruiting
Olive View UCLA Medical Center	Sylmar	California	91342	Recruiting
Childrens Hospital Colorado	Aurora	Colorado	80045	Recruiting
Nicklaus Childrens Hospital	Miami	Florida	33155	Recruiting
Massachusetts General Hospital	Boston	Massachusetts	02114	Recruiting
Boston Univ School of Medicine	Boston	Massachusetts	02118	Recruiting
University of Minnesota	Minneapolis	Minnesota	55455	Recruiting
Washington University in St Louis	St Louis	Missouri	63110	Recruiting
University of New Mexico	Albuquerque	New Mexico	87131-0001	Recruiting
Col Uni Med Center New York Presby	New York	New York	10032	Recruiting
University Of Cincinnati	Cincinnati	Ohio	45267	Recruiting
OHSU Dept of Nephrology	Portland	Oregon	97239	Recruiting
Univ of Pennsylvania Medical Center	Philadelphia	Pennsylvania	19104	Recruiting
MUSC Health Lancaster Med Ctr	Lancaster	South Carolina	29720	Recruiting
UT Southwestern Medical Center	Dallas	Texas	75235	Recruiting
Prolato Clinical Research Center	Houston	Texas	77054	Recruiting
Baylor Scott and White Research	Temple	Texas	76502	Recruiting
University of Utah	Salt Lake City	Utah	84113	Recruiting
University of Wisconsin	Madison	Wisconsin	53792	Recruiting

Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.

Non-U.S. locations

This page focuses on the U.S. directory. The official record also lists 106 non-U.S. sites.

About this trial record page

What this page shows: Public field values for ClinicalTrials.gov record NCT05755386, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
What this page does not do: No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
Where the data comes from: Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
Last refresh: Last update posted Apr 28, 2026 · Synced May 5, 2026

Open the official record

The complete protocol, eligibility criteria, and contact information for NCT05755386 live on ClinicalTrials.gov.

View official ClinicalTrials.gov record →