Phase 3 Trial to Evaluate the Efficacy and Safety of Aficamten Compared to Metoprolol Succinate in Adults With Symptomatic oHCM
Public ClinicalTrials.gov record NCT05767346. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
A Phase 3, Multi-center, Randomized, Double-blind Trial to Evaluate the Efficacy and Safety of Aficamten Compared to Metoprolol in Adults With Symptomatic Obstructive Hypertrophic Cardiomyopathy
Brief summary
Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.
The purpose of this study is to compare the efficacy and safety of aficamten (CK-3773274) compared with metoprolol succinate in adults with symptomatic hypertrophic cardiomyopathy and left ventricular outflow tract obstruction
Study identification
- NCT ID
- NCT05767346
- Recruitment status
- Completed
- Study type
- Interventional
- Phase
- Phase 3
- Enrollment
- 175 participants
Conditions and interventions
Eligibility (public fields only)
- Age range
- 18 Years to 85 Years
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Jun 20, 2023 (Actual)
- Primary completion
- Feb 28, 2025 (Actual)
- Completion
- Mar 28, 2025 (Actual)
- Last update posted
- Jun 9, 2026
2023 – 2025
United States locations
- U.S. sites
- 28
- U.S. states
- 20
- U.S. cities
- 24
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| Alaska Heart and Vascular Institute | Anchorage | Alaska | 99508 | — |
| Mayo Clinic | Phoenix | Arizona | 85054 | — |
| UC San Diego Health - Sulpizio Cardiovascular Center | La Jolla | California | 92037 | — |
| Cedars-Sinai Medical Center (Smidt Heart Institute) | Los Angeles | California | 90048 | — |
| Yale New Haven Hospital | New Haven | Connecticut | 06519 | — |
| AdventHealth | Orlando | Florida | 32804 | — |
| Emory Clinic | Atlanta | Georgia | 30322 | — |
| Piedmont Fayette Hospital | Fayetteville | Georgia | 30214 | — |
| Northwestern University | Evanston | Illinois | 60208 | — |
| Massachusetts General Hospital | Boston | Massachusetts | 02114 | — |
| Brigham and Women's Hospital | Boston | Massachusetts | 02115 | — |
| Lahey Hospital & Medical Center | Burlington | Massachusetts | 01803 | — |
| Henry Ford Hospital | Detroit | Michigan | 48202 | — |
| Saint Luke's Hospital of Kansas City | Kansas City | Missouri | 64111 | — |
| Morristown Medical Center | Morristown | New Jersey | 07960 | — |
| Columbia University Medical Center/New York Presbyterian Hospital | New York | New York | 10032 | — |
| Sanger Heart & Vascular Institute - HCM Clinic | Charlotte | North Carolina | 28204 | — |
| Duke Health Center Arringdon | Morrisville | North Carolina | 27560 | — |
| Providence St. Vincent Medical Center | Portland | Oregon | 97225 | — |
| Oregon Health & Science University | Portland | Oregon | 97239 | — |
| Division of Heart Failure and Transplantation (Hospital of the University of Pennsylvania) | Philadelphia | Pennsylvania | 19104 | — |
| Medical University of South Carolina | Charleston | South Carolina | 29425 | — |
| Ascension Saint Thomas Heart West | Nashville | Tennessee | 37205 | — |
| Vanderbilt University Medical Center | Nashville | Tennessee | 37232 | — |
| CHI St. Luke's Health Baylor-St. Luke's Medical Center | Houston | Texas | 77030 | — |
| Houston Methodist Hospital | Houston | Texas | 77030 | — |
| Intermountain Medical Center | Murray | Utah | 84107 | — |
| Inova Schar Heart and Vascular | Falls Church | Virginia | 22042 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
Non-U.S. locations
This page focuses on the U.S. directory. The official record also lists 43 non-U.S. sites.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT05767346, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Jun 9, 2026 · Synced Oct 21, 2026
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Open the official record
The complete public registry record, listed eligibility criteria, and available contact information for NCT05767346 live on ClinicalTrials.gov.