Study of AR-14034 in Participants With Neovascular Age-Related Macular Degeneration (nAMD)
Public ClinicalTrials.gov record NCT05769153. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
A Phase 1/2 Two-Stage Dose Escalation and Randomized Parallel-Group Study to Evaluate the Safety, Preliminary Treatment Effects, and Durability of AR-14034 Sustained Release Implant Compared to Intravitreal Anti-Vascular Endothelial Growth Factor Treatment in Participants With Neovascular Age-Related Macular Degeneration
Brief summary
Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.
The primary purpose of this study is to evaluate the safety and durability of single- and repeat administration of AR-14034 Sustained Release (SR) in subjects with neovascular age-related macular degeneration (nAMD).
Study identification
- NCT ID
- NCT05769153
- Recruitment status
- Active, not recruiting
- Study type
- Interventional
- Phase
- Phase 1, Phase 2
- Enrollment
- 139 participants
Conditions and interventions
Interventions
- AR-14034 SR implant lower dose Drug
- AR-14034 SR implant higher dose Drug
- AR-14034 SR implant Drug
- Aflibercept Injection Drug
- Sham procedure Drug
Drug
Eligibility (public fields only)
- Age range
- 50 Years and older
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Dec 6, 2023 (Actual)
- Primary completion
- Apr 2027 (Estimated)
- Completion
- Sep 2027 (Estimated)
- Last update posted
- Aug 27, 2026
2023 – 2027
United States locations
- U.S. sites
- 42
- U.S. states
- 19
- U.S. cities
- 40
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| Trinity Research Group | Dothan | Alabama | 36301 | — |
| Associated Retina Consultants - Gilbert | Gilbert | Arizona | 85297 | — |
| Associated Retina Consultants - Phoenix | Phoenix | Arizona | 85020 | — |
| Retina Associates of SW PC | Tucson | Arizona | 85704 | — |
| The Retina Partners | Encino | California | 91436 | — |
| Retina Associates of Orange County | Laguna Hills | California | 92653 | — |
| Northern California Retina Vitreous Associates Medical Group | Mountain View | California | 94040 | — |
| Eye Research Foundation | Newport Beach | California | 92663 | — |
| Azul Vision Pasadena | Pasadena | California | 99107 | — |
| Retina Consultants of Southern Colorado | Colorado Springs | Colorado | 80809 | — |
| Retina Group of New England | Waterford | Waterford | Connecticut | 06385 | — |
| Florida Retina Institute | Jacksonville | Florida | 32216 | — |
| Mid Florida Eye Center | Mt. Dora | Florida | 32757 | — |
| Florida Retina Institute | Orlando | Florida | 32806 | — |
| Retina Specialty Institute | Pensacola | Florida | 32503 | — |
| Eye Associates of Pinellas | Pinellas Park | Florida | 33782 | — |
| Center for Retina and Macular Disease | Winter Haven | Florida | 33880 | — |
| Southeast Retina Center | Augusta | Georgia | 30909 | — |
| Thomas Eye Group Main Office | Sandy Springs | Georgia | 30328 | — |
| University Retina and Macula Associates, PC | Oak Forest | Illinois | 60452 | — |
| Twin Cities Eye Consultants | Coon Rapids | Minnesota | 55433 | — |
| Mississippi Retina Associates | Madison | Mississippi | 39110 | — |
| Vision Research Center Eye Associates of New Mexico | Albuquerque | New Mexico | 87109 | — |
| NYC Retina - Queens | Forest Hills | New York | 11375 | — |
| University Hospitals Cleveland Medical Center | Cleveland | Ohio | 44106 | — |
| Verum Research, LLC | Eugene | Oregon | 97401 | — |
| Erie Retina Research | Erie | Pennsylvania | 16507 | — |
| MidAtlantic Retina Research | Philadelphia | Pennsylvania | 19107 | — |
| Retina Consultants of Carolina | Greenville | South Carolina | 29605 | — |
| Carolina Eyecare Physicians LLC | Mt. Pleasant | South Carolina | 29464 | — |
| Retina Research Institute of Texas | Abilene | Texas | 79606 | — |
| Texas Retina Associates - Arlington | Arlington | Texas | 76012 | — |
| Austin Research Center for Retina | Austin | Texas | 78705 | — |
| Austin Retina Associates | Austin | Texas | 78705 | — |
| Austin Clinical Research, LLC | Austin | Texas | 78750 | — |
| Star Vision Research | Burleson | Texas | 76028 | — |
| Texas Retina Associates | Dallas | Texas | 75231 | — |
| Berkeley Eye Center | Houston | Texas | 77027 | — |
| Retina Consultants of Texas - San Antonio | San Antonio | Texas | 78251 | — |
| Austin Retina Associates (San Marcos) | San Marcos | Texas | 78666 | — |
| Retina Research Center of Southern Utah | St. George | Utah | 84790 | — |
| Pacific Northwest Retina | Burlington | Washington | 98233 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT05769153, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Aug 27, 2026 · Synced Oct 21, 2026
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Open the official record
The complete public registry record, listed eligibility criteria, and available contact information for NCT05769153 live on ClinicalTrials.gov.