A Study to Evaluate the Efficacy and Safety of Sefaxersen (RO7434656) in Participants With Primary Immunoglobulin A (IgA) Nephropathy at High Risk of Progression

ClinicalTrials.gov ID: NCT05797610

Public ClinicalTrials.gov record NCT05797610. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.

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ClinicalTrials.gov public records Last synced May 16, 2026, 6:18 PM EDT

Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.

Official title

A Phase III, Multicenter, Randomized, Double-Blind, Placebo-Controlled Study to Evaluate the Efficacy and Safety of Sefaxersen, an Antisense Inhibitor of Complement Factor B, in Patients With Primary IgA Nephropathy at High Risk of Progression

Study identification

NCT ID: NCT05797610
Recruitment status: Recruiting
Study type: Interventional
Phase: Phase 3
Lead sponsor: Hoffmann-La Roche; Industry
Enrollment: 428 participants

Conditions and interventions

Conditions

Primary IgA Nephropathy

Interventions

Placebo Drug
Sefaxersen (RO7434656) Drug

Drug

Eligibility (public fields only)

Age range: 18 Years and older
Sex: All
Healthy volunteers: Healthy volunteers not accepted

This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.

Study timeline

Start date: Aug 7, 2023
Primary completion: Aug 30, 2026
Completion: Mar 30, 2029
Last update posted: May 10, 2026

2023 – 2029

United States locations

U.S. sites: 40
U.S. states: 19
U.S. cities: 37

Facility	City	State	ZIP	Site status
Alabama Kidney Research - ERN - PPDS	Alabaster	Alabama	35007-8823	Recruiting
UAB Nephrology Research Clinic	Birmingham	Alabama	35233	Recruiting
Sunrise Medical Management LLC	Surprise	Arizona	85374-8644	Withdrawn
Tucson Neuroscience Research - M3 WR	Tucson	Arizona	85710	Withdrawn
Kidney Disease Medical Group Inc-1505 Wilson Ter	Glendale	California	91206-4032	Recruiting
Southern California Medical Research Center	La Palma	California	90623	Withdrawn
Academic Medical Research Institute - Los Angeles	Los Angeles	California	90022	Recruiting
University of California, Los Angeles (UCLA) - Hematology/Oncology Santa Monica	Los Angeles	California	90025-4837	Recruiting
Los Angeles County Nephrology	Montebello	California	90640-2217	Recruiting
North America Research Institute-San Dimas	San Dimas	California	91773	Recruiting
Kaiser Permanente Skyport Medical Offices	San Jose	California	95110	Recruiting
BioResearch Partner ? Jackson West	Doral	Florida	33122	Recruiting
Hope Clinic & Research Center	Hialeah	Florida	33010	Withdrawn
LCC Medical Research - Miami - ClinEdge - PPDS	Miami	Florida	33126	Withdrawn
Central Florida Kidney Specialists	Orlando	Florida	32806	Recruiting
L&C Professional Medical Research Institute	West Miami	Florida	33144	Recruiting
Cowry Medical Group LLC	Acworth	Georgia	30101	Recruiting
Care Institute Idaho Kidney Institute	Chubbuck	Idaho	83202	Recruiting
Care Institute Idaho Kidney Institute	Idaho Falls	Idaho	83402	Recruiting
Nephrology Associates of Northern Illinois	Hinsdale	Illinois	60521	Recruiting
University of Iowa	Iowa City	Iowa	52242	Recruiting
Massachussets General Hospital	Boston	Massachusetts	02114	Recruiting
University of Mississippi Medical Center	Jackson	Mississippi	39216	Recruiting
Sierra Nevada Nephrology Consultants	Reno	Nevada	89511	Recruiting
NYU Langone Nephrology Associates - Mineola	Mineola	New York	11501	Recruiting
North Carolina Nephrology, PA	Raleigh	North Carolina	27609	Recruiting
Cleveland Clinic-9500 Euclid Ave	Cleveland	Ohio	44195-0001	Recruiting
Ohio State University Wexner Medical Center - Outpatient Care East	Columbus	Ohio	43203	Recruiting
Kidney and Hypertension Center	Roseburg	Oregon	97471	Withdrawn
Austin Diagnostic Clinic - Frenova F1	Austin	Texas	78751-3014	Recruiting
Global Medical Research - M3 WR	Dallas	Texas	75224	Withdrawn
Texas Kidney Institute - Dallas	Dallas	Texas	75231	Recruiting
Pioneer Research Solutions	Houston	Texas	077099	Recruiting
Prolato Clinical Research Center	Houston	Texas	77054	Recruiting
R & H Clinical Research	Katy	Texas	77449	Recruiting
Revival Research Institute - McKinney	McKinney	Texas	75071	Recruiting
Utah Kidney Research Institute	Salt Lake City	Utah	84115	Recruiting
Nephrology Associates of Northern Virginia Inc	Fairfax	Virginia	22033	Recruiting
Virginia Commonwealth University	Richmond	Virginia	23298	Recruiting
Milwaukee Nephrologists, Sc	Wauwatosa	Wisconsin	53226	Withdrawn

Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.

Non-U.S. locations

This page focuses on the U.S. directory. The official record also lists 164 non-U.S. sites.

About this trial record page

What this page shows: Public field values for ClinicalTrials.gov record NCT05797610, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
What this page does not do: No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
Where the data comes from: Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
Last refresh: Last update posted May 10, 2026 · Synced May 16, 2026

Open the official record

The complete protocol, eligibility criteria, and contact information for NCT05797610 live on ClinicalTrials.gov.

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