ClinicalTrials.gov record
Study to Assess Change in Disease Activity and Adverse Events of Oral Upadacitinib Compared to Subcutaneous Adalimumab in Adult Participants With Moderate to Severe Rheumatoid Arthritis
ClinicalTrials.gov ID: NCT05814627
Public ClinicalTrials.gov record NCT05814627. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
ClinicalTrials.gov public records Last synced May 6, 2026, 8:23 AM EDT
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
A Phase 3b/4 Randomized, Double-Blind, Double Dummy, Active Comparator-Controlled Study, Comparing the Efficacy and Safety of Upadacitinib Versus Adalimumab in Subjects With Moderate to Severe Rheumatoid Arthritis on a Stable Background of MTX and Who Had an Inadequate Response or Intolerance to a Single TNF Inhibitor (SELECT- SWITCH)
Study identification
- NCT ID
- NCT05814627
- Recruitment status
- Active, not recruiting
- Study type
- Interventional
- Phase
- Phase 3
- Lead sponsor
- AbbVie
- Industry
- Enrollment
- 487 participants
Conditions and interventions
Conditions
Interventions
- Adalimumab Drug
- Adalimumab Matching Placebo Drug
- Upadacitinib Drug
- Upadacitinib Matching Placebo Drug
Drug
Eligibility (public fields only)
- Age range
- 18 Years and older
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Jun 14, 2023
- Primary completion
- Jun 30, 2026
- Completion
- Jun 30, 2026
- Last update posted
- Jan 11, 2026
2023 – 2026
United States locations
- U.S. sites
- 85
- U.S. states
- 30
- U.S. cities
- 78
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| AZ Arthritis and Rheumotology Research, PLLC - Flagstaff /ID# 253431 | Flagstaff | Arizona | 86001-6299 | — |
| Arizona Arthritis and Rheumatology Research - Glendale Office /ID# 255018 | Glendale | Arizona | 85306-9802 | — |
| Sun Valley Arthritis Center Ltd. /ID# 254654 | Peoria | Arizona | 85381 | — |
| Arizona Arthritis & Rheumatology Associates - East Bell Road /ID# 253432 | Phoenix | Arizona | 85032 | — |
| Arizona Arthritis & Rheumatology Associates - East Bell Road /ID# 255021 | Phoenix | Arizona | 85032 | — |
| Arizona Arthritis & Rheumatology Associates - Tucson /ID# 255017 | Tucson | Arizona | 85704 | — |
| Arthritis and Rheumatism Associates /ID# 254013 | Jonesboro | Arkansas | 72401-6251 | — |
| Providence - St. Jude Medical Center /ID# 252690 | Fullerton | California | 92835 | — |
| Newport Huntington Medical Group /ID# 252687 | Huntington Beach | California | 92648-5994 | — |
| Purushotham & Akther Kotha MD, Inc /ID# 252704 | La Mesa | California | 91942 | — |
| Valerius Medical Group & Research Center of Greater Long Beach, Inc /ID# 252692 | Los Alamitos | California | 90720-5402 | — |
| Rheumatology Center of San Diego /ID# 255038 | San Diego | California | 92128-2549 | — |
| Millennium Clinical Trials /ID# 252689 | Thousand Oaks | California | 91360-3951 | — |
| The Lundquist Institute at Harbor-UCLA Medical Center /ID# 252691 | Torrance | California | 90502 | — |
| Comprehensive Rheumatology Center /ID# 252688 | Woodland Hills | California | 91364 | — |
| University of Colorado Hospital /ID# 254617 | Aurora | Colorado | 80045 | — |
| Denver Arthritis Clinic /ID# 254058 | Denver | Colorado | 80230 | — |
| Tekton Research - Fort Collins - East Harmony Road /ID# 255036 | Fort Collins | Colorado | 80528 | — |
| Arthritis and Rheumatic Disease Specialties /ID# 260583 | Aventura | Florida | 33180 | — |
| Rheumatology Associates of South Florida (RASF) - Clinical Research /ID# 253733 | Boca Raton | Florida | 33486 | — |
| Bay Area Arthritis and Osteo /ID# 254046 | Brandon | Florida | 33511 | — |
| Believe Clinical Trial /ID# 262355 | Coral Springs | Florida | 33065 | — |
| International Medical Research /ID# 254651 | Daytona Beach | Florida | 32117 | — |
| Omega Research Debary, LLC /ID# 253735 | DeBary | Florida | 32713-2260 | — |
| Neoclinical Research /ID# 254622 | Hialeah | Florida | 33016-1897 | — |
| Gnp Research - Hollywood /ID# 273563 | Hollywood | Florida | 33024 | — |
| Life Clinical Trials /ID# 256061 | Margate | Florida | 33063 | — |
| Lakes Research, LLC /ID# 255023 | Miami | Florida | 33014 | — |
| HMD Research LLC /ID# 253732 | Orlando | Florida | 32819 | — |
| Millennium Research /ID# 253744 | Ormond Beach | Florida | 32174 | — |
| Vitalia Research /ID# 274213 | Palm Beach Gardens | Florida | 33410 | — |
| BayCare Medical Group /ID# 253799 | St. Petersburg | Florida | 33705 | — |
| Clinical Research Of West Florida - Tampa - North Howard Avenue /ID# 254649 | Tampa | Florida | 33606 | — |
| Clinical Research Of West Florida - Tampa - North Howard Avenue /ID# 255264 | Tampa | Florida | 33606 | — |
| University of South Florida- Neuroscience Institute /ID# 253745 | Tampa | Florida | 33613 | — |
| Baycare Medical Group - Tampa /ID# 255268 | Tampa | Florida | 33614 | — |
| Atlanta Research Center For Rheumatology - Marietta /ID# 254623 | Marietta | Georgia | 30060 | — |
| Next Innovative Clinical Research - Chicago /ID# 273453 | Chicago | Illinois | 60616 | — |
| Deerbrook Medical Associates /ID# 254008 | Libertyville | Illinois | 60048 | — |
| OrthoIllinois /ID# 254057 | Rockford | Illinois | 61114-4937 | — |
| Greater Chicago Specialty Physicians /ID# 254000 | Schaumburg | Illinois | 60195-3106 | — |
| Clinic Of Dr. Robert Hozman/Clinical Investigation Specialists, Inc /ID# 253999 | Skokie | Illinois | 60076 | — |
| Willow Rheumatology and Wellness, PLLC /ID# 254712 | Willowbrook | Illinois | 60527 | — |
| Qualmedica Research - Evansville /ID# 254005 | Evansville | Indiana | 47715-2813 | — |
| Western KY Rheumatology /ID# 255026 | Hopkinsville | Kentucky | 42240 | — |
| Bluegrass Community Research /ID# 254653 | Lexington | Kentucky | 40504 | — |
| Ochsner Health Center - The Grove /ID# 254059 | Baton Rouge | Louisiana | 70836 | — |
| The Arthritis & Diabetes Clinic, Inc. /ID# 254014 | Monroe | Louisiana | 71203 | — |
| Rheumatology Associates PA - Portland /ID# 255014 | Portland | Maine | 04102-2643 | — |
| Beth Israel Deaconess Medical Center - Rheumatology /ID# 255029 | Boston | Massachusetts | 02149-4903 | — |
| AA Medical Research Center - Grand Blanc /ID# 254007 | Grand Blanc | Michigan | 48439 | — |
| Advanced Rheumatology, PC /ID# 256059 | Okemos | Michigan | 48910 | — |
| St. Paul Rheumatology, PA /ID# 255037 | Eagan | Minnesota | 55121 | — |
| Arthritis Associates /ID# 253992 | Hattiesburg | Mississippi | 39402 | — |
| Kansas City Physician Partners /ID# 255035 | Kansas City | Missouri | 64151 | — |
| Clinvest Research LLC /ID# 254054 | Springfield | Missouri | 65807 | — |
| Logan Health Research - Glacier View Research Institute - Rheumatology /ID# 253738 | Kalispell | Montana | 59901 | — |
| Physician Research Collaboration, LLC /ID# 254012 | Lincoln | Nebraska | 68516 | — |
| Dartmouth-Hitchcock Medical Center /ID# 253798 | Lebanon | New Hampshire | 03756 | — |
| Arthritis Rheumatic and Back Disease Associates. P.A. /ID# 255266 | Voorhees Township | New Jersey | 08043 | — |
| Arthritis and Osteoporosis Associates of New Mexico /ID# 252684 | Las Cruces | New Mexico | 88011 | — |
| NYU Langone Ambulatory Care Brooklyn Heights /ID# 254621 | Brooklyn | New York | 11201 | — |
| Joint And Muscle Research Institute /ID# 275128 | Charlotte | North Carolina | 28204 | — |
| Trinity Health Med Arts Clinic /ID# 254010 | Minot | North Dakota | 58701 | — |
| Paramount Medical Research and Consulting /ID# 254048 | Middleburg Heights | Ohio | 44130 | — |
| Rheumatology Associates of Oklahoma /ID# 253994 | Oklahoma City | Oklahoma | 73116-7226 | — |
| Clinical Research of Philadelphia, LLC /ID# 255025 | Philadelphia | Pennsylvania | 19114 | — |
| West Tennessee Research Institute /ID# 254620 | Jackson | Tennessee | 38305 | — |
| Arthritis and Rheumatology Research Institute, PLLC /ID# 254045 | Allen | Texas | 75013-6147 | — |
| Tekton Research, L.L.C /ID# 254004 | Austin | Texas | 78745 | — |
| Trinity Universal Research Associates - Carrollton /ID# 254648 | Carrollton | Texas | 75007 | — |
| Adriana Pop-Moody MD Clinic PA /ID# 255030 | Corpus Christi | Texas | 78404 | — |
| JPS Rheumatology Clinic /ID# 254050 | Fort Worth | Texas | 76104-4917 | — |
| Biopharma Informatic - Houston - Business Center Drive /ID# 254051 | Houston | Texas | 77043 | — |
| Accurate Clinical Research - Houston /ID# 254647 | Houston | Texas | 77089-6142 | — |
| Research Physicians Network, LLC /ID# 254053 | Houston | Texas | 77089 | — |
| R & H Clinical Research - 777 Katy /ID# 255024 | Katy | Texas | 77450-2244 | — |
| West Texas Clinical Research /ID# 253736 | Lubbock | Texas | 79424 | — |
| Trinity Universal Research Associates, Inc /ID# 253995 | Plano | Texas | 75024-5283 | — |
| Sun Research Institute /ID# 255019 | San Antonio | Texas | 78215 | — |
| Advanced Rheumatology of Houston /ID# 254003 | The Woodlands | Texas | 77382 | — |
| DM Clinical Research - Tomball /ID# 254001 | Tomball | Texas | 77375 | — |
| Rheumatology Clinic of Houston /ID# 254002 | Tomball | Texas | 77377 | — |
| Aurora Rheumatology and Immunotherapy Center /ID# 254049 | Franklin | Wisconsin | 53132 | — |
| Rheumatic Disease Center, LLP /ID# 254015 | Glendale | Wisconsin | 53217 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
Non-U.S. locations
This page focuses on the U.S. directory. The official record also lists 133 non-U.S. sites.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT05814627, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Jan 11, 2026 · Synced May 6, 2026
Related: full search, browse by condition, browse by drug or therapy, browse by sponsor, browse by U.S. city.
Open the official record
The complete protocol, eligibility criteria, and contact information for NCT05814627 live on ClinicalTrials.gov.