Efficacy, Safety, Tolerability, Pharmacodynamics, and Pharmacokinetics of BIA 28-6156 in GBA-PD
Public ClinicalTrials.gov record NCT05819359. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
A Phase 2, Randomized, Double-Blind, Placebo-Controlled Study to Evaluate the Efficacy, Safety, Tolerability, Pharmacodynamics, and Pharmacokinetics of BIA 28-6156 in Subjects With Parkinson's Disease With a Pathogenic Variant in the Glucocerebrosidase (GBA1) Gene
Brief summary
Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.
The purpose of this randomized, double-blind, placebo-controlled study is to assess the efficacy of BIA 28-6156 over placebo in delaying clinical meaningful motor progression over 78 weeks in subjects with Parkinson's disease who have a pathogenic variant in the glucocerebrosidase 1 (GBA1) gene (GBA-PD).
Study identification
- NCT ID
- NCT05819359
- Recruitment status
- Active, not recruiting
- Study type
- Interventional
- Phase
- Phase 2
- Enrollment
- 237 participants
Conditions and interventions
Conditions
Eligibility (public fields only)
- Age range
- 35 Years to 80 Years
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Mar 31, 2023 (Actual)
- Primary completion
- Apr 2, 2026 (Actual)
- Completion
- Jul 31, 2026 (Estimated)
- Last update posted
- May 13, 2026
2023 – 2026
United States locations
- U.S. sites
- 43
- U.S. states
- 23
- U.S. cities
- 33
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| Barrow Neurological Institute | Phoenix | Arizona | 85013 | — |
| University of California San Diego | La Jolla | California | 92037 | — |
| Cedars-Sinai | Los Angeles | California | 90048 | — |
| University of Colorado | Aurora | Colorado | 80045 | — |
| Parkinson's Center and Movement Disorders of Boca Raton | Boca Raton | Florida | 33486 | — |
| University of Miami, Dept. of Neurology | Miami | Florida | 33136 | — |
| Renstar Medical Research | Ocala | Florida | 34470 | — |
| Morehouse School of Medicine | Atlanta | Georgia | 30310 | — |
| Northwestern University | Chicago | Illinois | 60611 | — |
| Rush University Medical Center | Chicago | Illinois | 60612 | — |
| University of Iowa Hospitals and Clinics | Iowa City | Iowa | 52242 | — |
| University of Kansas Medical Center | Kansas City | Kansas | 66103 | — |
| University of Kentucky | Lexington | Kentucky | 40536 | — |
| University of Maryland Medical Center | Baltimore | Maryland | 21201 | — |
| Baylor University Medical Center | Baltimore | Maryland | 21287 | — |
| The Johns Hopkins University School of Medicine | Baltimore | Maryland | 21287 | — |
| Massachusetts General Hospital | Boston | Massachusetts | 02114 | — |
| Beth Israel Deaconess Medical Center | Boston | Massachusetts | 02115 | — |
| Quest Research Institute, LLC | Farmington Hills | Michigan | 48334 | — |
| Mayo Clinic | Rochester | Minnesota | 55905 | — |
| Struthers Parkinson's Center- East | Saint Paul | Minnesota | 55130 | — |
| Park Nicollet Struther's Parkinson's Center (Struthers Parkinsons Center at HealthPartners) | Saint Paul | Minnesota | 55427 | — |
| Robert Wood Johnson Medical School | New Brunswick | New Jersey | 08901 | — |
| Icahn School of Medicine at Mount Sinai Beth Israel | New York | New York | 10003 | — |
| Weil Cornell Medical Center | New York | New York | 10021 | — |
| Columbia University Medical Center | New York | New York | 10032 | — |
| Northwell Health Physician Partners | New York | New York | 10075-1851 | — |
| Northwell Health | New York | New York | 10075 | — |
| University of Rochester Neurology | Rochester | New York | 14642 | — |
| Cleveland Clinic Foundation | Cleveland | Ohio | 44195 | — |
| University Hospitals Cleveland Medical Center | South Euclid | Ohio | 44121 | — |
| Univerity of Toledo | Toledo | Ohio | 43614 | — |
| Oregon Health and Science University | Portland | Oregon | 97239 | — |
| Parkinson's Disease and Movement Disorders Cente at University of Pennyslvania | Philadelphia | Pennsylvania | 19107 | — |
| Thomas Jefferson University | Philadelphia | Pennsylvania | 19107 | — |
| MUSC | Charleston | South Carolina | 29425 | — |
| Vanderbilt Medical Center | Nashville | Tennessee | 37232 | — |
| Baylor College of Medicine | Houston | Texas | 77030 | — |
| University of Texas Health Science Center - San Antonio | San Antonio | Texas | 78229 | — |
| Intermountain Healthcare | Salt Lake City | Utah | 84107 | — |
| Evergreen Neuroscience Institute | Kirkland | Washington | 98034 | — |
| University of Washington | Seattle | Washington | 98195 | — |
| Inland Northwest Research | Spokane | Washington | 99202 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
Non-U.S. locations
This page focuses on the U.S. directory. The official record also lists 52 non-U.S. sites.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT05819359, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted May 13, 2026 · Synced Oct 24, 2026
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Open the official record
The complete public registry record, listed eligibility criteria, and available contact information for NCT05819359 live on ClinicalTrials.gov.