ClinicalTrials.gov record
Strategies and Treatments for Respiratory Infections &Amp; Viral Emergencies (STRIVE): Immune Modulation Strategy Trial
ClinicalTrials.gov ID: NCT05822583
Public ClinicalTrials.gov record NCT05822583. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Brief summary
Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.
COVID-19 can trigger a dysregulated immune response, and previous studies have shown that immune modulation can improve outcomes in hospitalized patients. This trial is designed to determine whether intensification of immune modulation early in the course of the disease (while patients are on low flow oxygen) with abatacept (active arm) combined with standard of care (SOC) improves recovery as compared with placebo + SOC (placebo arm). For both groups, intensification of immunomodulation will be provided as part of SOC in case of signs of disease progression (patient requires high flow nasal oxygen (HFNO) or more support) and/or if the patient has rapidly increasing oxygen requirement.
Study identification
- NCT ID
- NCT05822583
- Recruitment status
- Completed
- Study type
- Interventional
- Phase
- Phase 4
- Enrollment
- 285 participants
Conditions and interventions
Conditions
Eligibility (public fields only)
- Age range
- 18 Years and older
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Jul 6, 2023 (Actual)
- Primary completion
- Jun 21, 2025 (Actual)
- Completion
- Aug 11, 2025 (Actual)
- Last update posted
- Aug 31, 2026
2023 – 2025
United States locations
- U.S. sites
- 82
- U.S. states
- 34
- U.S. cities
- 61
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| University of Alabama Birmingham University Hospital (Site 213-002) | Birmingham | Alabama | 35233 | — |
| Banner University Medical Center Tucson (Site 206-004) | Tucson | Arizona | 85719 | — |
| Southern Arizona VA Healthcare System (Site 074-009) | Tucson | Arizona | 85723 | — |
| UC Davis Health (Site 203-004) | Davis | California | 95616 | — |
| UCSF Fresno (Site 203-005) | Fresno | California | 93721 | — |
| VA Loma Linda Healthcare System (074-017) | Loma Linda | California | 92357 | — |
| MemorialCare Health System (066-003) | Long Beach | California | 90806 | — |
| VA Long Beach Healthcare System (074-026) | Long Beach | California | 90822 | — |
| Cedars-Sinai Medical Center (208-002) | Los Angeles | California | 90048 | — |
| Ronald Reagan UCLA Medical Center (Site 203-002) | Los Angeles | California | 90095 | — |
| VA Northern California Health Care System (Site 074-023) | Mather | California | 95655 | — |
| VA San Diego Healthcare System (074-016) | San Diego | California | 92161 | — |
| Zuckerberg San Francisco General Hospital and Trauma Center (213-007) | San Francisco | California | 94110 | — |
| UCSF Medical Center at Mount Zion (203-007) | San Francisco | California | 94115 | — |
| San Francisco VAMC (Site 074-002) | San Francisco | California | 94121 | — |
| UCSF Medical Center (Site 203-001) | San Francisco | California | 94143 | — |
| Stanford University Hospital & Clinics (Site 203-003) | Stanford | California | 94305 | — |
| Rocky Mountain Regional VA Medical Center (Site 074-010) | Aurora | Colorado | 80045 | — |
| University of Colorado Hospital (Site 204-001) | Aurora | Colorado | 80045 | — |
| Public Health Institute at Denver Health (Site 017-004) | Denver | Colorado | 80204 | — |
| Yale University (Site 025-001) | New Haven | Connecticut | 06510 | — |
| MedStar Health Research Institute (Site 009-021) | Washington D.C. | District of Columbia | 20010 | — |
| Washington DC VA Medical Center (Site 009-004) | Washington D.C. | District of Columbia | 20422 | — |
| Tampa General Hospital (032-001) | Tampa | Florida | 33606 | — |
| Emory Grady (Site 301-032) | Atlanta | Georgia | 30303 | — |
| Hope Clinic, Emory University (Site 301-031) | Decatur | Georgia | 30030 | — |
| University of Illinois at Chicago (008-012) | Chicago | Illinois | 60612 | — |
| Lutheran Medical Group (301-010) | Fort Wayne | Indiana | 46804 | — |
| University of Kansas Medical Center (Site 080-044) | Kansas City | Kansas | 66160 | — |
| Massachusetts General Hospital (202-002) | Boston | Massachusetts | 02114 | — |
| Beth Israel Deaconess Medical Center (202-001) | Boston | Massachusetts | 02215 | — |
| Lahey Hospital and Medical Center (Site 213-001) | Burlington | Massachusetts | 01805 | — |
| Baystate Medical Center (Site 201-001) | Springfield | Massachusetts | 01199 | — |
| University of Massachusetts Chan Medical School (080-007) | Worcester | Massachusetts | 01655 | — |
| VA Ann Arbor Healthcare System (Site 074-028) | Ann Arbor | Michigan | 48105 | — |
| University of Michigan Medical Center (205-001) | Ann Arbor | Michigan | 48109 | — |
| Henry Ford Health System (014-001) | Detroit | Michigan | 48202 | — |
| Sinai-Grace Hospital (Site 205-005) | Detroit | Michigan | 48235 | — |
| M Health Fairview University of Minnesota Medical Center (112-001) | Minneapolis | Minnesota | 55455 | — |
| University of Minnesota | Minneapolis | Minnesota | 55455 | — |
| University of Mississippi Medical Center (Site 202-005) | Jackson | Mississippi | 39216 | — |
| Washington University School of Medicine (Site 003-001) | St Louis | Missouri | 63310 | — |
| University of Nebraska Medical Center (Site 080-045) | Omaha | Nebraska | 68198 | — |
| Dartmouth-Hitchcock Medical Center (301-024) | Lebanon | New Hampshire | 03756 | — |
| Cooper University Hospital (019-001) | Camden | New Jersey | 08103 | — |
| New Jersey Medical School Clinical Research Center (028-001) | Newark | New Jersey | 07103 | — |
| University of New Mexico Hospital (Site 213-008) | Albuquerque | New Mexico | 87106 | — |
| NYU Brooklyn (301-033) | Brooklyn | New York | 11220 | — |
| New York Presbyterian Queens (003-005) | Flushing | New York | 11355 | — |
| NYU Long Island (301-034) | Mineola | New York | 11501 | — |
| New York University Langone Health (301-013) | New York | New York | 10016 | — |
| NYC Health + Hospital Harlem (Site 003-003) | New York | New York | 10037 | — |
| Weill Cornell Clinical Research Unit (065-001) | New York | New York | 10065 | — |
| Mount Sinai Medical Center (Site 301-012) | New York | New York | 11234 | — |
| Lincoln Medical Center (Site 003-016) | The Bronx | New York | 10451 | — |
| James J. Peters VAMC (Site 023-003) | The Bronx | New York | 10468 | — |
| Duke University Hospital (Site 301-006) | Durham | North Carolina | 27710 | — |
| Wake Forest Baptist Health (Site 210-001) | Winston-Salem | North Carolina | 27157 | — |
| Cleveland Clinic Foundation (Site 207-001) | Cleveland | Ohio | 44195 | — |
| Oregon Health and Science University (208-003) | Portland | Oregon | 97239 | — |
| Penn State Health Milton S. Hershey Medical Center (Site 209-002) | Hershey | Pennsylvania | 17033 | — |
| Rhode Island Hospital (Site 080-036) | Providence | Rhode Island | 02903 | — |
| The Miriam Hospital (Site 080-039) | Providence | Rhode Island | 02906 | — |
| Ralph H. Johnson VA Medical Center (074-015) | Charleston | South Carolina | 29401 | — |
| Medical University of South Carolina (Site 210-002) | Charleston | South Carolina | 29425 | — |
| Vanderbilt University Medical Center (Site 212-001) | Nashville | Tennessee | 37232 | — |
| Hendrick Medical Center (Site 080-014) | Abilene | Texas | 79602 | — |
| CHRISTUS Spohn Shoreline Hospital (080-001) | Corpus Christi | Texas | 78404 | — |
| Parkland Health and Hospital Systems (084-002) | Dallas | Texas | 75235 | — |
| Baylor, Scott and White Health (301-003) | Dallas | Texas | 75246 | — |
| UT Southwestern Medical Center (084-001) | Dallas | Texas | 75390 | — |
| Houston Methodist Research Institute (Site 301-028) | Houston | Texas | 77030 | — |
| University of Texas Health Science Center (Site 203-006) | Houston | Texas | 77030 | — |
| UT Health San Antonio (Site 009-022) | San Antonio | Texas | 78229 | — |
| Intermountain Medical Center (Site 211-001) | Murray | Utah | 84107 | — |
| University of Utah Hospital (211-002) | Salt Lake City | Utah | 84108 | — |
| Salem VA Medical Center (Site 074-014) | Salem | Virginia | 24153 | — |
| Harborview Medical Center (208-001) | Seattle | Washington | 98104 | — |
| Providence (Sacred Heart) (213-004) | Spokane | Washington | 99204 | — |
| West Virginia University Medicine (Site 301-023) | Morgantown | West Virginia | 26506 | — |
| William S. Middleton Memorial Veterans Hospital (074-030) | Madison | Wisconsin | 53705 | — |
| Froedtert Memorial Lutheran Hospital (052-001) | Milwaukee | Wisconsin | 53226 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
Non-U.S. locations
This page focuses on the U.S. directory. The official record also lists 45 non-U.S. sites.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT05822583, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Aug 31, 2026 · Synced Oct 17, 2026
Related: full search, browse by condition, browse by drug or therapy, browse by sponsor, browse by U.S. city.
Open the official record
The complete public registry record, listed eligibility criteria, and available contact information for NCT05822583 live on ClinicalTrials.gov.