Non-invasive Vagal Nerve Stimulation in Opioid Use Disorders UH3
Public ClinicalTrials.gov record NCT05834478. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Brief summary
Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.
This study is being done to answer the question: what is the effect of Vagal Nerve Stimulation (VNS) dosing on opioid withdrawal responses in individuals with a history of Opioid Use Disorders (OUDs)? Eligible participants will be in the study for one week in an inpatient research hospital stay, have an MRI scan, and have a follow-up call 1-3 months after their inpatient stay. Participants will complete several psychiatric questionnaires/interviews, physiological monitoring with several devices, brain imaging, and VNS testing.
Study identification
- NCT ID
- NCT05834478
- Recruitment status
- Recruiting
- Study type
- Interventional
- Phase
- Phase 3
- Enrollment
- 103 participants
Conditions and interventions
Conditions
Interventions
- Transcutaneous Cervical Vagal Nerve Stimulation Device
- Sham Stimulation Device
- [F-18]Fallypride Drug
Device · Drug
Eligibility (public fields only)
- Age range
- 18 Years to 75 Years
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Feb 19, 2024
- Primary completion
- Jan 31, 2027
- Completion
- Mar 31, 2027
- Last update posted
- Mar 26, 2026
2024 – 2027
United States locations
- U.S. sites
- 6
- U.S. states
- 1
- U.S. cities
- 1
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| Emory University Clinical Research Network | Atlanta | Georgia | 30322 | Recruiting |
| Health Sciences Research Building | Atlanta | Georgia | 30322 | Not yet recruiting |
| Rollins School of Public Health | Atlanta | Georgia | 30322 | Recruiting |
| 12 Executive Park Drive | Atlanta | Georgia | 30329 | Recruiting |
| Emory University | Atlanta | Georgia | 30329 | Recruiting |
| Georgia Institute of Technology | Atlanta | Georgia | 30332 | Recruiting |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT05834478, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Mar 26, 2026 · Synced Sep 6, 2026
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Open the official record
The complete protocol, eligibility criteria, and contact information for NCT05834478 live on ClinicalTrials.gov.