Multi-center, Open-label, Single-ascending Dose Study of Safety and Tolerability of TN-201 in Adults With Symptomatic MYBPC3 Mutation-associated HCM

ClinicalTrials.gov ID: NCT05836259

Public ClinicalTrials.gov record NCT05836259. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.

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ClinicalTrials.gov public records Last synced May 20, 2026, 2:10 AM EDT

Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.

Official title

First-in-Human, Open-Label, Safety, Tolerability, Dose-Finding, Pharmacodynamic and Cardiac Transgene Expression Study of TN-201, a Recombinant Adeno-associated Virus Serotype 9 (AAV9) Containing Myosin Binding Protein C Transgene, in Adults With MYBPC3 Mutation-associated Hypertrophic Cardiomyopathy (HCM)

Study identification

NCT ID: NCT05836259
Recruitment status: Recruiting
Study type: Interventional
Phase: Phase 1, Phase 2
Lead sponsor: Tenaya Therapeutics; Industry
Enrollment: 30 participants

Conditions and interventions

Conditions

Hypertrophic Cardiomyopathy

Interventions

TN-201 Genetic

Genetic

Eligibility (public fields only)

Age range: 18 Years to 75 Years
Sex: All
Healthy volunteers: Healthy volunteers not accepted

This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.

Study timeline

Start date: Aug 9, 2023
Primary completion: Jul 31, 2027
Completion: Jul 31, 2032
Last update posted: Mar 18, 2026

2023 – 2032

United States locations

U.S. sites: 10
U.S. states: 8
U.S. cities: 10

Facility	City	State	ZIP	Site status
UC San Diego Altman Clinical and Translational Research Institute - Center for Clinical Research	La Jolla	California	92093	Recruiting
University of California San Francisco	San Francisco	California	94117	Recruiting
Emory University	Atlanta	Georgia	30322	Withdrawn
Brigham and Women's Hospital	Boston	Massachusetts	02115	Withdrawn
Mayo Clinic	Rochester	Minnesota	55905	Recruiting
The Christ Hospital Physicians - The Ohio Heart and Vascular Center	Cincinnati	Ohio	45219	Withdrawn
Cleveland Clinic	Cleveland	Ohio	44195	Recruiting
Oregon Health & Science University	Portland	Oregon	97239	Withdrawn
Hospital of the University of Pennsylvania	Philadelphia	Pennsylvania	19104	Withdrawn
Houston Methodist Hospital	Houston	Texas	77030	Recruiting

Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.

About this trial record page

What this page shows: Public field values for ClinicalTrials.gov record NCT05836259, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
What this page does not do: No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
Where the data comes from: Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
Last refresh: Last update posted Mar 18, 2026 · Synced May 20, 2026

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The complete protocol, eligibility criteria, and contact information for NCT05836259 live on ClinicalTrials.gov.

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