Fast Induced Remodeling in Heart Failure With Preserved Ejection Fraction
Public ClinicalTrials.gov record NCT05839730. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Brief summary
Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.
FIRE-HFpEF is a multi-center, prospective, randomized, single-blinded, clinical feasibility study. This study will enroll up to 105 subjects with heart failure with preserved ejection fraction in the United States. Data will be collected to evaluate whether pacing therapies can lead to improvements in exercise capacity and health status of subjects.
Study identification
- NCT ID
- NCT05839730
- Recruitment status
- Active, not recruiting
- Study type
- Interventional
- Phase
- Not applicable
- Enrollment
- 105 participants
Conditions and interventions
Interventions
- Pacemaker PLR + TRT ON Device
- Pacemaker non-pacing mode or an exertional rate-adaptive pacing mode with no planned pacing at rest. Device
Device
Eligibility (public fields only)
- Age range
- 18 Years and older
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Sep 11, 2024 (Actual)
- Primary completion
- Oct 2027 (Estimated)
- Completion
- Oct 2027 (Estimated)
- Last update posted
- Aug 3, 2026
2024 – 2027
United States locations
- U.S. sites
- 8
- U.S. states
- 7
- U.S. cities
- 8
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| NCH Heart Institute | Naples | Florida | 34102 | — |
| Prairie Education and Research Cooperative-St. Elizabeth's | O'Fallon | Illinois | 62269 | — |
| Prairie Education and Research Cooperative-St. John's | Springfield | Illinois | 62769 | — |
| University of Kansas Medical Center | Kansas City | Kansas | 66160 | — |
| Duke University | Durham | North Carolina | 27708 | — |
| Oklahoma Heart Hospital | Oklahoma City | Oklahoma | 73120 | — |
| Houston Methodist Research Institute | Houston | Texas | 77030 | — |
| The University of Vermont Medical Center | Burlington | Vermont | 05401 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT05839730, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Aug 3, 2026 · Synced Oct 22, 2026
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Open the official record
The complete public registry record, listed eligibility criteria, and available contact information for NCT05839730 live on ClinicalTrials.gov.