TINI 2: Total Therapy for Infants With Acute Lymphoblastic Leukemia II
Public ClinicalTrials.gov record NCT05848687. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Brief summary
Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.
The purpose of this study is to improve upon the TINI study treatment. The study will test the ability of a type of immunotherapy called blinatumomab to clear persistent leukemia. Blinatumomab targets CD19 which is located on the leukemia cells outer membrane.
Study identification
- NCT ID
- NCT05848687
- Recruitment status
- Recruiting
- Study type
- Interventional
- Phase
- Phase 1, Phase 2
- Enrollment
- 90 participants
Conditions and interventions
Conditions
Interventions
- Dexamethasone Drug
- Mitoxantrone Drug
- PEG asparaginase Drug
- Bortezomib Drug
- Vorinostat Drug
- Mercaptopurine Drug
- Methotrexate Drug
- Blinatumomab Drug
- Ziftomenib Drug
Drug
Eligibility (public fields only)
- Age range
- Up to 1 Year
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Nov 2, 2023
- Primary completion
- Nov 30, 2028
- Completion
- Nov 30, 2033
- Last update posted
- Jun 2, 2026
2023 – 2033
United States locations
- U.S. sites
- 17
- U.S. states
- 12
- U.S. cities
- 17
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| Phoenix Children's Hospital | Phoenix | Arizona | 85016 | Recruiting |
| Arkansas Children's Hospital | Little Rock | Arkansas | 72202 | Recruiting |
| Children's Hospital Los Angeles | Los Angeles | California | 90027 | Recruiting |
| Valley Children's Hospital | Madera | California | 93636 | Recruiting |
| Children's Hospital of Orange County | Orange | California | 92868 | Recruiting |
| Stanford University | Palo Alto | California | 94304 | Recruiting |
| Rady Children's Hospital San Diego | San Diego | California | 92123 | Not yet recruiting |
| Arnold Palmer Hospital for Children | Orlando | Florida | 32806 | Recruiting |
| Children's Hospital of Minnesota | Minneapolis | Minnesota | 55404 | Recruiting |
| Memorial Sloan Kettering Cancer Center | New York | New York | 10065 | Recruiting |
| Novant Health - Hemby Children's Hospital | Charlotte | North Carolina | 28204 | Not yet recruiting |
| Doernbecher Children's Hospital | Portland | Oregon | 97239 | Recruiting |
| Penn State Milton S Hershey Medical Center | Hershey | Pennsylvania | 17033-0850 | Recruiting |
| MD Anderson | Houston | Texas | 77030 | Recruiting |
| University of Texas Health Science Center San Antonio | San Antonio | Texas | 78229 | Recruiting |
| University of Utah Huntsman Cancer Institute | Salt Lake City | Utah | 84108 | Recruiting |
| Children's Hospital of The King's Daughters | Norfolk | Virginia | 23507 | Recruiting |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
Non-U.S. locations
This page focuses on the U.S. directory. The official record also lists 7 non-U.S. sites.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT05848687, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Jun 2, 2026 · Synced Sep 2, 2026
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Open the official record
The complete protocol, eligibility criteria, and contact information for NCT05848687 live on ClinicalTrials.gov.