A Phase 1-2 of ST316 With Selected Advanced Unresectable and Metastatic Solid Tumors
Public ClinicalTrials.gov record NCT05848739. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
A Phase 1-2 Dose-escalation and Expansion Study of ST316 in Subjects With Selected Advanced Unresectable and Metastatic Solid Tumors
Brief summary
Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.
This is an open-label, two-part, phase 1-2 study designed to determine the safety, tolerability, PK, pharmacodynamics (PD), and proof-of-concept efficacy of ST316 administered IV in subjects with selected advanced solid tumors likely to harbor abnormalities of the WNT/β-catenin signaling pathway. The study consists of two phases: a phase 1 dose escalation/regimen exploration phase and a phase 2 expansion phase.
Study identification
- NCT ID
- NCT05848739
- Recruitment status
- Active, not recruiting
- Study type
- Interventional
- Phase
- Phase 1
- Enrollment
- 130 participants
Conditions and interventions
Conditions
Interventions
- ST316 Drug
- FOLFIRI regimen & bevacizumab Drug
- Fruquintinib Drug
- Lonsurf & bevacizumab Drug
Drug
Eligibility (public fields only)
- Age range
- 18 Years and older
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Jun 4, 2023
- Primary completion
- Dec 30, 2026
- Completion
- Dec 30, 2027
- Last update posted
- Jul 21, 2026
2023 – 2027
United States locations
- U.S. sites
- 11
- U.S. states
- 11
- U.S. cities
- 11
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| University of Alabama | Birmingham | Alabama | 35294 | — |
| USC Norris Comprehensive Cancer Center | Los Angeles | California | 90033 | — |
| Sarah Cannon Research Institute - CO | Denver | Colorado | 80218 | — |
| Ochsner Clinic Foundation | New Orleans | Louisiana | 70123 | — |
| Beth Israel Deaconess Medical Center | Boston | Massachusetts | 02215 | — |
| START Midwest | Grand Rapids | Michigan | 49503 | — |
| Westchester Medical Center | Valhalla | New York | 10595 | — |
| Duke Universtiy | Durham | North Carolina | 27708 | — |
| OU Health Stephenson Cancer Center | Oklahoma City | Oklahoma | 73104 | — |
| Sanford Cancer Center | Sioux Falls | South Dakota | 57104 | — |
| Fred Hutch Cancer Center | Seattle | Washington | 98109 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT05848739, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Jul 21, 2026 · Synced Sep 8, 2026
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Open the official record
The complete protocol, eligibility criteria, and contact information for NCT05848739 live on ClinicalTrials.gov.