A Phase II Study of AAA617 Alone and AAA617 in Combination With ARPI in Patients With PSMA PET Scan Positive CRPC
Public ClinicalTrials.gov record NCT05849298. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
An International Prospective Open-label, Multi-center, Randomized, Non-comparative Phase II Study of Lutetium [177Lu] Vipivotide Tetraxetan (AAA617) Alone and Lutetium [177Lu] Vipivotide Tetraxetan (AAA617) in Combination With Androgen Receptor Pathway Inhibitors in Patients With PSMA PET Scan Positive Castration-Resistant Prostate Cancer
Study identification
- NCT ID
- NCT05849298
- Recruitment status
- Active, not recruiting
- Study type
- Interventional
- Phase
- Phase 2
- Lead sponsor
- Novartis Pharmaceuticals
- Industry
- Enrollment
- 49 participants
Conditions and interventions
Conditions
Interventions
- AAA517 Drug
- AAA617 Drug
- ADT Drug
- ARPI Drug
- Best supportive care Other
- Piflufolastat F 18 Drug
Drug · Other
Eligibility (public fields only)
- Age range
- 18 Years to 100 Years
- Sex
- Male
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Jan 2, 2024
- Primary completion
- Dec 22, 2026
- Completion
- Dec 22, 2026
- Last update posted
- Apr 12, 2026
2024 – 2026
United States locations
- U.S. sites
- 18
- U.S. states
- 12
- U.S. cities
- 16
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| Urology Associates of Mobile | Mobile | Alabama | 36608 | — |
| Rocky Mountain Cancer Centers | Denver | Colorado | 80218 | — |
| University Of Florida | Jacksonville | Florida | 32218 | — |
| University Cancer and Blood Center LLC | Athens | Georgia | 30607 | — |
| Urology Of Indiana | Indianapolis | Indiana | 46254 | — |
| Unity Point Clinic | Des Moines | Iowa | 50323 | — |
| Urology Cancer Center PC | Omaha | Nebraska | 68130 | — |
| Associated Med Professionals of NY | Syracuse | New York | 13210 | — |
| Oregon Urology Institute | Springfield | Oregon | 97477 | — |
| Wellspan York Hospital | York | Pennsylvania | 17403 | — |
| Coastal Cancer Center | Conway | South Carolina | 29526 | — |
| Carolina Urologic Research Center | Myrtle Beach | South Carolina | 29572 | — |
| Carolina Regional Cancer Center | Myrtle Beach | South Carolina | 29577 | — |
| Urology Clinic of North Texas | Dallas | Texas | 75231 | — |
| Univ of Texas Southwest Med Center | Dallas | Texas | 75390-9034 | — |
| Rio Grande Urology | El Paso | Texas | 79912 | — |
| Houston Methodist Hospital | Houston | Texas | 77030 | — |
| UT Health San Antonio Mays Cancer Center | San Antonio | Texas | 78229 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
Non-U.S. locations
This page focuses on the U.S. directory. The official record also lists 23 non-U.S. sites.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT05849298, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Apr 12, 2026 · Synced May 7, 2026
Related: full search, browse by condition, browse by drug or therapy, browse by sponsor, browse by U.S. city.
Open the official record
The complete protocol, eligibility criteria, and contact information for NCT05849298 live on ClinicalTrials.gov.