A Phase I/II Study of Trametinib and Azacitidine for Patients With Newly Diagnosed Juvenile Myelomonocytic Leukemia
Public ClinicalTrials.gov record NCT05849662. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
Risk Stratified Treatment for Patients With Newly Diagnosed Juvenile Myelomonocytic Leukemia: A Phase I/II Non-randomized Study of Trametinib and Azacitidine With or Without Chemotherapy (IND #164058)
Study identification
- NCT ID
- NCT05849662
- Recruitment status
- Recruiting
- Study type
- Interventional
- Phase
- Phase 1, Phase 2
- Lead sponsor
- Therapeutic Advances in Childhood Leukemia Consortium
- Other
- Enrollment
- 58 participants
Conditions and interventions
Interventions
- Azacitidine Drug
- Cytarabine Drug
- Fludarabine Drug
- Trametinib Drug
Drug
Eligibility (public fields only)
- Age range
- 1 Month to 21 Years
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Oct 10, 2024
- Primary completion
- Nov 30, 2028
- Completion
- Nov 30, 2029
- Last update posted
- Apr 14, 2026
2024 – 2029
United States locations
- U.S. sites
- 19
- U.S. states
- 18
- U.S. cities
- 19
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| Phoenix Children's Hospital | Phoenix | Arizona | 85016 | Recruiting |
| Children's Hospital Los Angeles | Los Angeles | California | 900027 | Recruiting |
| University of California San Francisco | San Francisco | California | 94158 | Recruiting |
| Children's Hospital of Colorado | Denver | Colorado | 80045 | Recruiting |
| Children's National Medical Center | Washington D.C. | District of Columbia | 20010 | Recruiting |
| University of Miami | Miami | Florida | 33136 | Recruiting |
| Children's Hospital of Atlanta | Atlanta | Georgia | 30322 | Recruiting |
| Lurie Children's Hospital of Chicago | Chicago | Illinois | 60611 | Recruiting |
| Indiana University/Riley Hospital for Children | Indianapolis | Indiana | 46202 | Recruiting |
| Sidney Kimmel Cancer Center at Johns Hopkins | Baltimore | Maryland | 21231 | Recruiting |
| C.S. Mott Children's Hospital | Ann Arbor | Michigan | 48109 | Recruiting |
| Children's Mercy Hospital | Kansas City | Missouri | 64108 | Recruiting |
| Memorial Sloan Kettering Cancer Center | New York | New York | 10065 | Recruiting |
| Cincinnati Children's Hospital Medical Center | Cincinnati | Ohio | 45229 | Recruiting |
| Oregon Health & Science University | Portland | Oregon | 97239 | Recruiting |
| Children's Hospital of Philadelphia | Philadelphia | Pennsylvania | 19104 | Recruiting |
| St. Jude Children's Research Hospital Memphis | Memphis | Tennessee | 38105 | Recruiting |
| Primary Children's Hospital | Salt Lake City | Utah | 84113 | Recruiting |
| Seattle Children's Hospital | Seattle | Washington | 98105 | Recruiting |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT05849662, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Apr 14, 2026 · Synced May 8, 2026
Related: full search, browse by condition, browse by drug or therapy, browse by sponsor, browse by U.S. city.
Open the official record
The complete protocol, eligibility criteria, and contact information for NCT05849662 live on ClinicalTrials.gov.