ClinicalTrials.gov record
A Study to Learn How Well a Higher Amount of Aflibercept Given as an Injection Into the Eye Works and How Safe it is in People With Reduced Vision Due to Swelling in the Macula, Central Part of the Retina Caused by a Blocked Vein in the Retina (Macula Edema Secondary to Retinal Vein Occlusion)
ClinicalTrials.gov ID: NCT05850520
Public ClinicalTrials.gov record NCT05850520. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
ClinicalTrials.gov public records Last synced May 19, 2026, 3:47 PM EDT
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
Randomized, Double-Masked, Active-Controlled, Phase 3 Study of the Efficacy and Safety of Aflibercept 8 mg in Macular Edema Secondary to Retinal Vein Occlusion
Study identification
- NCT ID
- NCT05850520
- Recruitment status
- Completed
- Study type
- Interventional
- Phase
- Phase 3
- Lead sponsor
- Bayer
- Industry
- Enrollment
- 892 participants
Conditions and interventions
Interventions
- Aflibercept, VEGF Trap-Eye(Eylea, BAY86-5321)_2 mg Drug
- Aflibercept, VEGF Trap-Eye(Eylea, BAY86-5321)_higher dose Drug
- Fluorescein Diagnostic Test
- Sham Drug
Drug · Diagnostic Test
Eligibility (public fields only)
- Age range
- 18 Years and older
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- May 14, 2023
- Primary completion
- Nov 6, 2024
- Completion
- May 26, 2025
- Last update posted
- Dec 17, 2025
2023 – 2025
United States locations
- U.S. sites
- 53
- U.S. states
- 24
- U.S. cities
- 51
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| Retina Consultants of Orange County - Fullerton | Fullerton | California | 92835 | — |
| South Coast Retina - Long Beach | Long Beach | California | 90807 | — |
| Northern California Retina Vitreous Associates - Mountain View Office | Mountain View | California | 94040 | — |
| Desert Retina Consultants - Palm Springs Office | Palm Springs | California | 92262 | — |
| Azul Vision Pasadena | Pasadena | California | 91107 | — |
| Retina Consultants of Southern California | Redlands | California | 92374 | — |
| Retina Consultants of Southern Colorado, PC | Colorado Springs | Colorado | 80909 | — |
| New England Retina Associates | New London | Connecticut | 06320 | — |
| Rand Eye Institute | Deerfield Beach | Florida | 33064 | — |
| National Ophthalmic Research Institute - Fort Myers | Fort Myers | Florida | 33912 | — |
| The Eye Institute of West Florida - Largo | Largo | Florida | 33770 | — |
| Florida Eye Associates - Melbourne Main Office | Melbourne | Florida | 32901 | — |
| Florida Retina Institute - Orlando | Orlando | Florida | 32806 | — |
| Retina Specialty Institute - Pensacola | Pensacola | Florida | 32503 | — |
| Fort Lauderdale Eye Institute | Plantation | Florida | 33324 | — |
| Retina Vitreous Associates of Florida - Saint Petersburg | St. Petersburg | Florida | 33711 | — |
| East Florida Eye Institute | Stuart | Florida | 34994 | — |
| Center for Retina and Macular Disease - Winter Haven | Winter Haven | Florida | 33880 | — |
| Marietta Eye Clinic | Marietta | Georgia | 30060 | — |
| Retina Associates - Elmhurst | Elmhurst | Illinois | 60126 | — |
| University Retina and Macula Associates - Oak Forest | Oak Forest | Illinois | 60452 | — |
| Retina Associates - Lenexa | Lenexa | Kansas | 66215 | — |
| The Retina Care Center - Baltimore | Baltimore | Maryland | 21209 | — |
| Cumberland Valley Retina Consultants | Hagerstown, MD | Hagerstown | Maryland | 21740 | — |
| Mid Atlantic Retina Specialists - Hagerstown | Hagerstown | Maryland | 21740 | — |
| Vitreo-Retinal Associates - Worcester | Grand Rapids | Michigan | 49525 | — |
| RCM - St. Louis Park Retina Clinic | Saint Louis Park | Minnesota | 55416 | — |
| Retina Consultants of Nevada - Summerlin | Las Vegas | Nevada | 89144 | — |
| Retina Center of New Jersey | Bloomfield | New Jersey | 07003 | — |
| NJ Retina - New Brunswick | New Brunswick | New Jersey | 08901 | — |
| NJ Retina | Teaneck | Teaneck | New Jersey | 07666 | — |
| Vision Research Center | Albuquerque | New Mexico | 87109 | — |
| Vitreoretinal Consultants of NY - Great Neck | Great Neck | New York | 11021 | — |
| Vitreoretinal Consultants of NY - Hauppauge | Hauppauge | New York | 11788 | — |
| Ophthalmic Consultants of Long Island | Lynbrook | New York | 11563 | — |
| Retina Associates of Western New York | Rochester | New York | 14620 | — |
| Cincinnati Eye Institute - Blue Ash | Blue Ash | Ohio | 45242-5664 | — |
| Midwest Retina - Main Office | Dublin | Ohio | 43016 | — |
| Retina Consultants, LLC | Salem | Oregon | 97302 | — |
| Mid Atlantic Retina - Bethlehem | Bethlehem | Pennsylvania | 18107 | — |
| Mid Atlantic Retina - Philadelphia / Wills Eye Hospital | Philadelphia | Pennsylvania | 19107 | — |
| Palmetto Retina Center, LLC - Florence | Florence | South Carolina | 29501 | — |
| Retina Consultants of South Carolina - Ladson | Ladson | South Carolina | 29456 | — |
| Charles Retina Specialists - Germantown | Memphis | Tennessee | 38119 | — |
| Austin Retina Associates - Central | Austin | Texas | 78705 | — |
| Retina Consultants of Texas - Bellaire | Bellaire | Texas | 77401 | — |
| Texas Retina Associates - Fort Worth | Fort Worth | Texas | 76104 | — |
| Medical Center Ophthalmology Associates - Northwest | San Antonio | Texas | 78240 | — |
| Retina Consultants of Texas - San Antonio Medical Center | San Antonio | Texas | 78240 | — |
| Rocky Mountain Retina Consultants - Main Office | Salt Lake City | Utah | 84107 | — |
| The Retina Group of Washington - Fairfax | Fairfax | Virginia | 22031 | — |
| Spokane Eye Clinical Research - South Hill / Downtown | Spokane | Washington | 99204 | — |
| UW Health Carbone Cancer Center | Madison | Wisconsin | 53792 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
Non-U.S. locations
This page focuses on the U.S. directory. The official record also lists 220 non-U.S. sites.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT05850520, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Dec 17, 2025 · Synced May 19, 2026
Related: full search, browse by condition, browse by drug or therapy, browse by sponsor, browse by U.S. city.
Open the official record
The complete protocol, eligibility criteria, and contact information for NCT05850520 live on ClinicalTrials.gov.